Rat Plasma
Determination of metformin in rat plasma using high performance liquid chromatography and its application to pharmacokinetic study
... blank plasma samples collected from six different rats to investigate the potential interferences in the liquid chromatographic peak region for the analyte and IS using the proposed extraction procedure and ...
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Original Article Development and optimization of a RP-HPLC method to quantify midazolam in rat plasma after transdermal administration: validation and application in pharmacokinetic study
... in rat plasma and its validation in transdermal drug delivery ...in plasma for 24 h after transdermal ...in rat after a single transdermal ...
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Determination on Vildagliptin in Rat Plasma by Capillary Electrophoresis Tandem Mass Spectrometry: It’s Application to Pharmacokinetic Study
... from rat plasma. Methodology: Vildagliptin was estimated in rat plasma after precipitation of plasma proteins by acetonitrile, using sitagliptin as internal ...from plasma ...
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Determination of lesinurad in rat plasma by a UHPLC–MS/MS assay
... To evaluate the stability of the method, lesinurad lev- els in rat plasma were assessed using six replications at three concentrations (10, 1000, and 25,000 ng/mL). These experiments evaluated the stability ...
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Rapid and simple RPHPLC method for the estimation of metformin in rat plasma
... A simple reverse phase high-performance liquid chromatographic method has been developed for determining the concentration of metformin in rat plasma. The method employs C 18 column (300 mm × 2.4 mm i.d.), ...
5
New high-performance liquid chromatography-dad method for analytical determination of arbutin and hydroquinone in rat plasma
... in rat plasma, after an acute and subacute administration of aqueous arbutin solution in Wistar ...in plasma of female rats treated with aqueous arbutin ...
6
Simple and sensitive HPLC UV method for determination of bexarotene in rat plasma
... Intra-day validation results of the analytical method of bexarotene in human and mouse plasma using HPLC-UV n = 6 Human plasma Concentration levels.. RE, relative error; RSD, relative st[r] ...
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Iron uptake from rat plasma transferrin by rat reticulocytes
... Fast and slow rat transferrins were isolated by isoelectric focusing and prepared in their di- and monoferric forms. A comparison of the rates of iron release between fast and slow monoferric transferrins when ...
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Comparative studies on the multi component pharmacokinetics of Aristolochiae Fructus and honey fried Aristolochiae Fructus extracts after oral administration in rats
... The QC samples were assayed under several different conditions to evaluate the stability of AAs in rat plasma. The freeze-thaw stability of the analyte was determined over three freeze-thaw cycles. In each ...
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Detection and mechanistic comparison of two anti-trypanosomal diamidines in a rat renal model
... Figure 31 Lower limit of quantification standard (2.5 ng/mL) for furamidine in rat plasma analyzed by LC/MS/MS.. Figure 32 Untreated rat kidney analyzed by LC/MS/MS.[r] ...
173
<p>Inhibitory Effect of <em>Lygodium</em> Root on the Cytochrome P450 3A Enzyme in vitro and in vivo</p>
... Although RLMs incubation can re fl ect metabolism to a certain extent, it is still dif fi cult to illustrate real metabolism in the human or animal body. In this study, we developed a UPLC-MS/MS method for the ...
11
Design and synthesis of nanoscaled IQCA-TAVV as a delivery system capable of antiplatelet activation, targeting arterial thrombus and releasing IQCA
... and rat plasma IQCA-TAVV form nanoparticles that not only could be suitably delivered in blood circulation but also could adhere onto the surface of activated platelets, and thereby inhibit the activation ...
20
Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models
... the plasma protein binding ability of DTX captured in Poly- sorbate 80 micelles and DTX captured in Polysorbate 80/Phospholipid mixed micelles, ...mL rat plasma was full mixed with ...L plasma ...
12
Preparation of honokiol nanoparticles by liquid antisolvent precipitation technique, characterization, pharmacokinetics, and evaluation of inhibitory effect on HepG2 cells
... As shown in Figure 8, the honokiol concentration in the rat plasma of the honokiol nanoparticle-treated group was consistently higher than that of the free honokiol-treated[r] ...
15
Squalene in Human and Rat Blood Plasma
... Approximately half the free sterol fractions from the three lipoproteins corresponding to rat plasma sample A, and from those of the third 4.8-hour human plasma sample, were each combine[r] ...
7
The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection
... the rat plasma and has been validated to be sensitive to investigate the pharmacokinetics of bergapten in ...maximum plasma concentration achieved within 3 h after dosing (5 mg kg −1 ) as seen in ...
8
Studies on the biological activity of porcine proinsulin
... However, since no conversion of proinsulin occurred either during the period of in vitro incubation with diaphragm or in the rat plasma in vivo, it is difficult to ascribe any effect of [r] ...
11
Bioanalytical Method Development and Validation of Pirfenidone by Rp-Hplc Method and its Application to the Determination of Drug Food Interaction Study in Wister Rats.
... and plasma sample under developed chromatographic ...in rat plasma was determined from the calibration of the spiked plasma by regression ...
77
OPTIMIZATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DOLUTEGRAVIR AND RILPIVIRINE IN BINARY MIXTURE BY USING DESIGN OF EXPERIMENTS
... Development and validation of RP- HPLC method for the estimation of Dolutegravir and Rilpivirine in bulk and Pharmaceutical dosage form and its application to rat plasma. [r] ...
13
The effect of vitamin C on plasma volume in the early stage of sepsis in the rat
... given. Plasma volume was measured ( 125 I-dilution technique) at baseline, at 3 h after end of initiation of sepsis and at the end of the experiment 3 h ...
8