receptor dimerization
Kinetic analysis of antagonist occupied adenosine A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism
... the receptor is selectively monitored by FCS with a fluorescent antagonist ligand and that important insights into ligand binding kinetics, ligand residence time, allosterism, and receptor ...
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Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry
... in dimerization of the ...the dimerization of the receptor ...the receptor to induce NF-κB nuclear trans- location following HIV-1 binding, thus suggesting that these mutations could reduce ...
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Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization
... As an initial step to investigate whether the expression pattern of D2R might be altered in schizophrenia, we carried out Western blot analysis with all 60 formalin- fixed paraffin-embedded human postmortem striatal ...
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Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization
... GPCRs comprise the largest family of transmembrane pro- teins and represent major targets for drug discovery (Williams and Hill, 2009; Roth and Marshall, 2012). Considerable advances in our knowledge of GPCR structure ...
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Glucocorticoid receptor dimerization induces MKP1 to protect against TNF induced inflammation
... Both exogenous and endogenous glucocorticoids (GCs) protect against TNF-induced lethal inflammation (6, 7). The binding of GCs to the GC receptor (GR) protects against TNF lethality, as shown by the use of GR ...
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Characterization and Targeting of Thromboxane Receptor Dimerization: A Gateway to Novel Therapeutic Developments
... GPCR dimerization contributes to post-translational regulation of receptor expression and function, therefore we characterized how TP forms dimers with itself (homodimerization) or other related receptors ...
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Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization
... the dimerization domains intracellularly to regulate CAR ...the dimerization and led to reduced ...and dimerization architecture and had minimal in vitro and no in vivo functional validation, making ...
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Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments
... IL-4Ra/IL-13Ra1 dimerization at the cell surface concentrations of endogenous receptors, which typically are below 1 molecule per mm 2 ...in receptor dimerization was neglected by this ...the ...
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Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants
... asymmetric dimerization is a crucial mechanism of their oncogenic activation and consequent cellular ...asymmetric dimerization may be induced and/or favored by increased local concentration of mutant EGFR ...
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Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization
... factor-induced receptor dimerization and cross-phosphorylation are hallmarks of signal transduction via receptor tyrosine kinases ...RTK dimerization and ...factor receptor b (PDGFRb) ...
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Intracellular signaling pathways of ErbB2/HER 2 and family members
... Thus, receptor dimerization of ErbB1 with ErbB2 may not only prolong signaling by modulating ligand binding properties as dis- cussed earlier, but also by altering receptor ...ErbB receptor ...
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Modulation of fibroblast growth factor 2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin mimicking polyanionic compound
... FGF-2 receptor binding in both the soluble and membrane-bound re- ceptor ...FGFR dimerization, activation, and signaling (14, 25, ...fact, dimerization of FGFR could not be detected at a concentra- ...
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ALK inhibitor resistance in ALKF1174L-driven neuroblastoma is associated with AXL activation and induction of EMT
... AXL receptor dimerization and activation through autopho- sphorylation has been reported to occur through binding of its physiological ligand GAS6 that triggers a cascade of intracellular signaling events ...
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Structural implications of RNA dimerization in a gamma retrovirus
... Retroviral dimerization is a well conserved event among retroviruses and thus is not only a potential target for disruption in anti-viral therapies, but is monumental for understanding the retroviral life ...the ...
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Consequences of Dimerization of the Voltage-Gated Proton Channel
... 1 The position of the gH–V relationship appears to be 10–15 mV more positive in monomeric constructs than WT dimeric channels.52,53 In enhanced gating mode, the gH–V relationship shifts [r] ...
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Gal80 Dimerization and the Yeast GAL Gene Switch
... Figure 3.—Gal80 single-amino-acid substitu- tion variants selected as impaired in interaction with Gal4AD (those in Figure 2) are full length, expressed at equivalent levels to wild-type[r] ...
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Effect of dimerization on the field-induced birefringence in ferrofluids
... Chain formation presents another source of anisotropy in the ferrofluid, but if nanoparticles have anisotropic shape, chains affect the birefringence only when the volume fraction of nan[r] ...
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Anion–anion dimerization in tetrabutylammonium hydrogensulfate
... The title compound, I, crystallizes in a large monoclinic cell with four tetrabutylammonium ions and four hydrogensulfate ions in the asymmetric unit.. Each hydrogensulfate ion donates a[r] ...
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Conserved determinants of lentiviral genome dimerization
... with increasing amounts of the cognate NC proteins also resulted in significant equilibrium shifts toward the dimer as detected using the TBM running buffers. However, gels obtained for the same samples using TB as the ...
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Mechanism of retroviral genomic RNA dimerization and packaging
... The output from a SHAPE experiment includes three components: a plus (+) reagent trace (blue), a background trace (–) that omits the reagent (green), and a deoxynucleotide sequencing ladder which is used to assign sites ...
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