Recombinant bone morphogenetic protein 2
Comparison of two independent systematic reviews of trials of recombinant human bone morphogenetic protein-2 (rhBMP-2): the Yale Open Data Access Medtronic Project
... Conducting the systematic reviews and IPD meta-analysis Following controversy in the literature surrounding adverse events related to rhBMP-2 including cancer, in August 2011, Medtronic agreed to participate in ...
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Allogeneic morphogenetic protein vs. recombinant human bone morphogenetic protein-2 in lumbar interbody fusion procedures: a radiographic and economic analysis
... of bone morphogenetic proteins (BMPs) naturally found within the bone ...allogeneic bone grafts has be- come available as a substitute or extender to autograft [2], yet with limited ...
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Combined effect of bisphosphonate and recombinant human bone morphogenetic protein 2 on bone healing of rat calvarial defects
... reducing bone loss by reducing or stopping the function of osteoclast [8, ...socket, bone fracture or increase the bone density of the interface after titanium implant placement [12 – ...
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Schwartz, Daniel (2005): Development of an Aqueous Suspension of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2): Entwicklung einer wässrigen Suspension des recombinanten menschlichen Knochenwachstumsproteins-2 (rhBMP-2). Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... iliac-crest bone graft for lumbar interbody fusions in a sheep model showed superiority of the BMP group compared to the autograft control group with respect to histologic evaluation of fusion rate after 6 months ...
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β Tricalcium Phosphate Combined with Recombinant Human Bone Morphogenetic Protein 2: A Substitute for Autograft, Used for Packing Interbody Fusion Cages in the Canine Lumbar Spine
... outcomes as autogenous bone in the examinations of micro- radiographs and histological sections. Thus, we expect that - TCP can be used as a substitute for autogenous bone for the interbody fusion cages. ...
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
... In this study, we sought to identify antibody(ies) capa- ble of blocking the activity of BMPR2. We started our search with three strict criteria: (1) the antibody must be raised against the region of BMPR2 exposed to the ...
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Siliceous mesostructured cellular foams/ poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) composite biomaterials for bone regeneration
... the recombinant human bone morphogenetic protein (rhBMP-2) on the surfaces of the scaffolds, the scaffolds were immersed in 5 mL rhBMP-2 solutions (100 µ g/mL) at room ...
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THE EFFECT OF RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 ON THE OSSEOINTEGRATION OF TEMPORARY ANCHORAGE DEVICES
... approximately 10 mm in diameter and 2mm in height. The onplant is usually located subperiosteally on the posterior portion of the hard palate, and with a transpalatal arch, the onplant is attached to the orthodontic ...
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Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in posterolateral lumbar spine fusion: complications in the elderly
... poor bone quality void of osteoinductive ma- terial in elderly patients, a large amount of iliac crest bone graft is ...of bone harvest related com- plications, and frequently is inadequate or ...
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The effect of locally delivered recombinant human bone morphogenetic protein-2 with hydroxyapatite/tri-calcium phosphate on the biomechanical properties of bone in diabetes-related osteoporosis
... in bone metabolism and exert their effects on bone through the tightly coupled processes of osteo- clastogenesis and osteoblastogenesis ...in bone regeneration, several delivery models have been ...
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Hypertrophy is induced during the in vitrochondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein 2 and bone morphogenetic protein 4 gene transfer
... using recombinant proteins, where BMP-4 was identified as a strong inducer of chondro- genesis [36], which produced less hypertrophy compared with BMP-2 ...and bone formation when delivered as ...
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Rapid bone regeneration by Escherichia coli-derived recombinant human bone morphogenetic protein-2 loaded on a hydroxyapatite carrier in the rabbit calvarial defect model
... of recombinant human BMP-2 (rhBMP-2) [4, 5]. However, BMP-2 derived from Chinese hamster ovary cells (CHO BMP-2) is relatively costly be- cause protein yields are ...in ...
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Effects of Polycaprolactone Tricalcium Phosphate, Recombinant Human Bone Morphogenetic Protein 2 and Dog Mesenchymal Stem Cells on Bone Formation: Pilot Study in Dogs
... Group 2: PCL-TCP + aFG + dMSCs; Group 3: PCL-TCP + aFG + dMSCs + rhBMP-2; Group 4: PCL-TCP + aFG + dMSCs + rhBMP-2 + PCL ...Group 2 in two weeks and four weeks after the ...that bone ...
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“Evolving Trends in Biopolymer Based Drug Delivery Systems: An Overview” by Soruba Evangeline, Vickram Sundaram, Ramesh Pathy Manian, Sridharan Balasundaram, India.
... structural protein, which gives structure and support to the tissues connecting them with the ...containing recombinant human bone morphogenetic protein 2 (rhBMP-2) was ...
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Sustained delivery of recombinant human bone morphogenetic protein-2 from perlecan domain I - functionalized electrospun poly (ε-caprolactone) scaffolds for bone regeneration
... control over bone healing and a risk of inflammation (Luginbuehl et al. 2004; DeCarlo and Whitelock 2006; Lee et al. 2012). To address these problems, efforts have been directed towards developing rhBMP delivery ...
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Bone regenerative effect of recombinant human bone morphogenetic protein-2 after cyst enucleation
... Methods: Under general anesthesia, 10 patients (12 lesions) underwent oral or maxillofacial surgery for cyst enucleation. Postoperatively, 12 lesions were divided into two groups: group A (six lesions) was treated with ...
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Depot injectable biodegradable nanoparticles loaded with recombinant human bone morphogenetic protein-2: preparation, characterization, and in vivo evaluation
... (Table 2). In group B (negative control), plasma levels of rhBMP-2 were untrace- able during the entire 96-hour period of release (Figure ...few bone spicules in some slides and complete absence of ...
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Original Article rhBMP-2 applied as support of distraction osteogenesis: a split-mouth histological study over nonhuman primates mandibles
... the recombinant human bone morphogenetic protein type 2 (rhBMP2) to a collagen matrix applied on a distraction osteogenesis device would help healing in the middle new formed ...bovine ...
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Characterization of a shorter recombinant polypeptide chain of bone morphogenetic protein 2 on osteoblast behaviour
... ectopic bone in extra-skeletal sites in animals [15, ...towards bone forming osteoblasts ...of recombinant proteins, concerns have been raised regarding their transient bioactivity, protein ...
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OSSEOINTEGRATION OF TEMPORARY ANCHORAGE DEVICES USING RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2
... stimulating bone growth in a variety of applications. Specifically, INFUSE® Bone Graft (Medtronic Sofamor Danek, Memphis, TN), which consists of rhBMP-2 in combination with an absorbable collagen ...
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