Regulatory CD4+ T cell
Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs
... as T cells, B cells, fibroblast-like syno- viocytes, macrophages, and dendritic cells ...various regulatory CD4 + T cell subsets, collectively termed ...
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Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation
... cells, while later studies used more stringent definitions including expression of the transcription factor FoxP3 and/or low expression of CD127. PM diagnosis and cate- gorization also differed in prior studies. Most ...
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The control of CD4+CD25+Foxp3+regulatory T cell survival
... B, T, and natural killer (NK) cell development, leading to severe combined immunodeficiency in humans and mice ...naïve CD4 and memory CD8 cells respectively, are well documented ...of cell ...
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Increased production of soluble CTLA 4 in patients with spondylarthropathies correlates with disease activity
... on T cells and its ligands, CD80 and CD86, present on the antigen presenting cells (APC) are the proto- typical costimulatory molecules ...Cytotoxic T lymphocyte associated molecule-4 (CTLA-4 or CD152) is ...
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Modulation of the CD8+-T-Cell Response by CD4+ CD25+ Regulatory T Cells in Patients with Hepatitis B Virus Infection
... ⫹ T cells (patients 1, 2, 3, and 4) and two patients with no detectable HLA-A2-restricted HBV-specific CD8 ⫹ cells (patient 5 and ...of CD4 ⫹ CD25 ⫹ cells did not have any impact on HBeAg ⫹ pa- tients with ...
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Signal Transduction in T Helper Cells: CD4 Coreceptors Exert Complex Regulatory Effects on T Cell Activation and Function
... human CD4 suggests that the membrane proximal domains of CD4 may promote dimerization (Wu et ...of CD4 oligomers from freshly isolated T lymphocytes and lymphoid cell lines also ...
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Koutrolos, Michail (2013): Role of regulatory T cells in experimental autoimmune encephalomyelitis: a functional and imaging study. Dissertation, LMU München: Fakultät für Biologie
... ) regulatory T cells (Treg) are critical for maintaining immune homeostasis and self-tolerance, as well as modulating immune responses in the contexts of infection, autoimmunity, cancer and transplantation ...
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Vahl, Johann Christoph (2013): TCR signals in the identity and function of mature NKT and regulatory T cells. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... TCR-switched T cells prevented a more dramatic form of autoimmune inflammation, we injected mice with PD-L1 and PD-L2 blocking or control antibodies twice a week for 4 consecutive weeks, starting 2 d before switch ...
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Lack of Intrinsic CTLA-4 Expression Has Minimal Effect on Regulation of Antiviral T-Cell Immunity
... developing T-cell responses, the receptor pair CD28 and cytotoxic T-lymphocyte (CTL) antigen 4 (CTLA-4/CD152) has received considerable attention in the past years ...of T-cell ...
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Epitope-Specific Regulatory CD4 T Cells Reduce Virus-Induced Illness while Preserving CD8 T-Cell Effector Function at the Site of Infection
... CD8 T cells (3, 8) and could negatively regulate regulatory T cells by controlling STAT-5 phosphorylation ...PD-1-expressing CD4 T cells were reported to be defective in TCR-mediated ...
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JMJD3 regulates CD4+ T cell trafficking by targeting actin cytoskeleton regulatory gene Pdlim4
... in cell motility, cell death, and cell proliferation were confirmed by quantitative real-time PCR anal- ysis (Figure ...Jmjd3-cKO CD4 SP T cells when compared with WT CD4 SP ...
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<p>PD-1 inhibitors dependent CD8<sup>+</sup> T cells inhibit mouse colon cancer cell metastasis</p>
... memory T cell and decreased CD4 + FoxP3 + regulatory T cell in MLNs and spleen, as well as increased secretion of IFN- γ and TNF- α ...that CD4 + FoxP3 + regula- tory ...
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Regulatory T cells (CD4+CD25+FOXP3+) in lupus nephritis
... that T cells are crucial in its pathogenesis. T cells enhance the production of autoantibodies by offering substantial help to B cells to trigger SLE related ...
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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells
... that T cells that overexpress FoxP3 (from mice bearing a FoxP3 transgene) do not proliferate or produce cytokines upon TCR stimulation but undergo rapid apoptosis ...stimulated T cells under- going ...
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Krishnamoorthy, Gurumoorthy (2007): Devic mouse: a spontaneous double-transgenic mouse model of human opticospinal multiple sclerosis and autoimmune T- B cell cooperation. Dissertation, LMU München: Fakultät für Biologie
... poor T cell stimulatory activity of APCs (Waldner et ...addition, CD4 + CD25 + regulatory cells (Tregs), which also contribute to the resistance and depletion of Tregs, restored their ...
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Immunotherapy of Murine Retrovirus-Induced Acquired Immunodeficiency by CD4 T Regulatory Cell Depletion and PD-1 Blockade
... target cell type that is essential for the progression of viral pathogenesis to become ...several cell types should become infected, some perhaps irrel- evant to the initiation and progression of ...
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CD4+CD25+FOXP3+ Regulatory T Cells In Allogeneic Hematopoietic Cell Transplantation
... donor T cells transferred along with the marrow graft directly recognize antigenic differences on antigen-presenting cells of the ...donor T cells that specifically respond to the host compartment can ...
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CD4(+)CD25(hi)CD127(low) Regulatory T Cells Are Increased in Oral Squamous Cell Carcinoma Patients
... known to be a mechanism of immune suppression [72,73]. The increase expression of IL-10 in head and neck squamous cell carcinoma patients remains controversial. Several studies have suggested that patients with ...
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Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
... Soluble IgA production increased in SAMP1/YitFc versus AKR mice. (A) Representative dot plots of κ (1:100 dilution, FL2) and λ (1:1, FL1) light chain antibody isotype levels within MLN supernatants from AKR mice (n = 2) ...
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The Effect of T Cell Receptor Specificity on CD4+CD25+ Regulatory T Cell Function in an Autoimmune Setting
... whether CD4 + CD25 + cells from TS1xHACII mice could exert suppressor function in response to stimulation by S1 peptide, we conducted in vitro suppression assays using S1 peptide to stimulate the ...CFSE-labeled ...
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