Replication Fork Rates of Different Cell Types
Visualizing chromosomal rearrangements caused by replication fork stalling in a single cell
... Reviewing the literature seeking for similar observations on genome rearrangements has been revealed that genomic instability can be initiated by DSBs. DSBs is a common proceeding cause of CRs. There are two major ...
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Topological challenges to DNA replication: Conformations at the fork
... ⌬Lk could travel freely throughout the chromosome, these forks would have serious consequences for the cell. Because the daughter strands are not topologically constrained, they could not be supercoiled (see Fig. ...
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Dissecting The Functions Of Atr In Replication Fork Stability
... oncogene-induced replication stress give rise to different landscapes of fragile sites that only partially overlap with one another (Miron et ...to cell cycle checkpoint abrogation and could bring ...
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The human mitochondrial replication fork in health and disease
... many different types of RNA primers in a sequence independent ...coupled replication in vitro by combining the basal replication and transcription machinery (unpublished ...
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Viral Transport of DNA Damage That Mimics a Stalled Replication Fork
... ied cell lines deficient for different repair proteins and the corresponding lines with the deficiency complemented as well as cell lines expressing siRNA ...of cell line pairs, they were ...
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Defining Sites Of Replication Fork Collapse Caused By Atr Inhibition
... the cell to propagate in a deregulated fashion will increase our understanding of cancer ...a cell to inherit a proclivity for certain diseases will expand our understanding of the mechanisms of genetic ...
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Retroviral mutation rates and A-to-G hypermutations during different stages of retroviral replication.
... in different stages of retroviral replication is based on the fact that mutations in the LTR regions during early and late stages of retroviral replication result in integrated proviruses with ...
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Susceptibility of different leukocyte cell types to Vaccinia virus infection
... MVA vaccinia virus strain has elicited much interest recently because of its safety record. Because clinical com- plications and side effects of smallpox vaccination are a critical issue in the event of mass vaccination, ...
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Mechanisms modulating transcribed chromatin topology and suppressing replication fork instability
... DNA replication, recombination, cell division and metabolism; which are well conserved from yeast to higher eukaryotes, including ...the cell cycle is relatively concise with respect to higher ...
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DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression
... The ability to identify ORC binding sites in a variety of dif- ferentiated cell types has revealed a high degree of tissue specificity of origin positioning within the genome. Although ORC is enriched at ...
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Modeling Assemblies and Interactions at the Replication Fork: Sliding Clamps and Clamp Interacting Enzymes
... from different areas of study includ- ing experimental, physical, bioinformatics, and statistical have to be ...how different types of experimental data could be translated into one of the four ...
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Home Mortgage Rates - The Different Types
... interest rates are likely to rise an average of 1% per year for each of the next four years, so he also wants to take these expectations into account as ...
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A process model of replication studies: on the relation between different types of replication
... Through meta-analysis it can be tested what varia- tions in relevant parameters influence the results, and whether the outcome of the original study indeed can be considered to be replic[r] ...
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Replication fork rescue in mammalian mitochondria
... meeting replication forks that occur at the non-coding region (NCR) of mtDNA 33 , we focused on a region spanning nts 12,273–16,012 of mtDNA, generated by DraI restriction ...strand-asynchronous replication ...
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Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1
... to replication inhibitors but not ionizing radiation in HCT116 or SW480 cells depleted of ...essential replication helicase cofactor Cdc45, suggesting that H2AX phosphorylation occurs at sites of stalled ...
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Replication of polyoma DNA in isolated nuclei: analysis of replication fork movement.
... The movement of replication forks during polyoma DNA synthesis in isolated nuclei was analyzed by digesting newly synthesized DNA with the restriction.. endonuclease HpaII which cleaves [r] ...
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Overexpression of the Replicative Helicase in Escherichia coli Inhibits Replication Initiation and Replication Fork Reloading
... inhibits replication by promoting continual rebinding of DnaC to DnaB and consequent prevention of helicase ...during replication repair sensitise cells to dnaB ...increased replication blockage and ...
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Reduced rate of DNA replication fork movement in megaloblastic anemia
... unlabeled medium the label was progressively transferred to the double-stranded fraction over a period of 2--3 h. The rate of transfer was slower in megaloblastic lymphocytes than in controls. The difference in rate ...
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Roles of Replication Protein-A Subunits 2 and 3 in DNA Replication Fork Movement in Saccharomyces cerevisiae
... Replication Protein-A, the eukaryotic SSB, consists of a large subunit (RPA1) with strong ssDNA binding activity and two smaller subunits (WAS and 3) that may coope[r] ...
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Parvovirus Initiator Protein NS1 and RPA Coordinate Replication Fork Progression in a Reconstituted DNA Replication System
... processive replication initiated from oriL TC ...Again, replication occurring in each reaction was quantitated by measuring total incorpora- tion of [ 32 P]dAMP, and reaction products were analyzed by ...
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