Resistant mutant
Isolation and Characterization of an Aluminum-resistant Mutant in Rice
... Al-resistant mutant ral1 (resistance to aluminum 1). ral1 mutant showed short root phenotype under normal growth condition, which was attributed to reduced cell elongation in the ...ral1 ...
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Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase resistant mutant mice
... were resistant to the effects of PTH in inducing osteoclastic bone resorption, effects of PTH in stimulating collage- nase expression in osteoblasts were intact in the r/r ...
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Effect of aphidicolin on vaccinia virus: isolation of an aphidicolin-resistant mutant.
... DEFILIPPES Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205 Received 12 April 1984/Accepted 1 August 1984 Vaccinia virus grow[r] ...
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Inhibition by lipiarmycin of bacteriophage growth in Bacillus subtilis.
... For phage 4105, phage development was sensitive to both lipiarmycin and rifampin in wild-type cells and resistant to both drugs in resistant mutant cells, leading to the conclusion that [r] ...
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Assessing the Viral Fitness of Oseltamivir-Resistant Influenza Viruses in Ferrets, Using a Competitive-Mixtures Model
... oseltamivir-resistant mutant virus) or mixed populations of wild-type and oseltamivir-resistant influenza viruses (80%:20%, 50%:50%, and 20%:80%) at equivalent infectivity titers, and the changes in ...
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Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells
... acquired resistant mutant EGFR (L858R/T790M)-driven H1975 cells, we sought to explore a drug combination strategy to potentiate the growth inhibitory efficacy of ...gatekeeper mutant T790M causes ...
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GENETIC ANALYSIS OF MULTIPLE DRUG CROSS RESISTANCE IN SACCHAROMYCES CEREVISIAE: A NUCLEAR-MITOCHONDRIAL GENE INTERACTION
... Tetrad analysis of diploids obtained from crosses between the resistant mutant and a sensitive wild-type strain suggest that the multiple resistance to the five agents, oligomyci[r] ...
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Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication.
... 67/70/215/219 mutant virus (derived from NL4-3) in the absence of an inhib- ...by mutant virus RT in the presence of low dNTP concentrations might only be evident after mito- genic ...of mutant ...
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Genetic characterization of the vaccinia virus DNA polymerase: identification of point mutations conferring altered drug sensitivities and reduced fidelity.
... Characterization of an aphidicolin-resistant mutant of herpes simplex virus type 2 which induces an altered viral DNA polymerase.. Drug-resistant mutants of herpes simplex virus type 2 w[r] ...
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Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... variants resistant to protease (PR) and reverse transcriptase (RT) inhibitors may display impaired infectivity and replication ...drug-resistant mutant viral isolates into the wild-type NL4-3 ...
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COMBINATION THERAPY AND ITS IMPLICATION ON CLINICAL EFFICACY OF ARTEMISININS REVIEW
... viable resistant mutant parasites are selected at much lower ...simultaneously resistant mutant (i.e., resistant to both A and B) will arise spontaneously every 1 in 10 24 ...
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Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.
... BWr, a new acyclovir-resistant mutant derived from the Patton strain of herpes simplex virus type 1, induced a DNA polymerase resistant to inhibition by acyclovir triphosphate, but, unli[r] ...
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Multifunctionality of a Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition
... large movements in the template channel and in the  9- ␣ 11 loop. The structural alterations have to be interpreted in the context of an increasing number of picornavirus RdRp structures trapped into multiple stages of ...
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GENETIC STRUCTURE OF BACTERIOPHAGE T4 AS DESCRIBED BY RECOMBINATION STUDIES OF FACTORS INFLUENCING PLAQUE MORPHOLOGY
... Phage stocks were cultured in the enriched nutrient broth medium used by HERSHEY and ROTMAN (1949).. A TG-resistant mutant of HERSHEY and ROTMAN'S.[r] ...
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Epidemiology of ‘Extended Spectrum Beta Lactamae’ producing isolates of Escherichia coli and Klebsiella spp among bacteremic adults admitted to a tertiary care teaching hospita
... isolates resistant to either cefotaxime or ceftazidime by the disc diffusion test were tested for phenotypic confirmation of ESBL production, by the double disc diffusion test according to the CLSI performance ...
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Mitochondrial oxidative stress is the achille’s heel of melanoma cells resistant to Braf-mutant inhibitor
... 4 resistant sub-lines maintained elevated levels of p-MEK1/2 and p-ERK1/2 upon vemurafenib ...the resistant sub-lines suggesting distinct mechanisms of resistance ...remained resistant to the MEK1/2 ...
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ERECTA family genes coordinate stem cell functions between the epidermal and internal layers of the shoot apical meristem
... Fig. 3. CLV3pro:GUS expression is specifically maintained in the epidermis of the wus er erl1 erl2 SAM. (A-D) CLV3pro:GUS signals in sections of SAM tissue from 10-day-old plants of various genotypes. Scale bars: 100 μ ...
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High-Frequency Phenotypic Reversion and Pathogenicity of an Acyclovir-Resistant Herpes Simplex Virus Mutant
... the mutant virus syn- thesizes a little TK, either by exploiting the reduced fidelity of the DNA polymerase when replicating homopolymeric runs (giving rise to a heterogeneous population) (26) or as the result of ...
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A Functional Peroxisome Proliferator-activated Receptor-γ Ligand-binding Domain Is Not Required for Adipogenesis
... To determine the adipogenic potential of PPAR␥ Q286P at a molecular level, the expression of mRNAs characteristic of mature fat cells was followed during the time course of differentiation. These mRNAs encode proteins ...
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Changes in hysteretic kinetics and properties of key regulatory enzymes of wild type & mutant strains of Synechococcus cedrorum during pesticide (endosulfan) stress combat
... These results taken together show that the mutant EndR strain achieves resistance to 2.5-fold higher doses of endosulfan by regulation of the hysteretic behaviour of G6PDH, mediated via protein factors. Both the ...
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