Reverse-transcriptase inhibitor
A Mutation in the 3′ Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Y318F) Associated with Nonnucleoside Reverse Transcriptase Inhibitor Resistance
... 7. Hertogs, K., M. P. de Bethune, V. Miller, T. Ivens, P. Schel, A. Van Cau- wenberge, C. Van Den Eynde, V. Van Gerwen, H. Azijn, M. Van Houtte, F. Peeters, S. Staszewski, M. Conant, S. Bloor, S. Kemp, B. Larder, and R. ...
5
Nonnucleoside Reverse Transcriptase Inhibitor-Resistant HIV Is Stimulated by Efavirenz during Early Stages of Infection
... Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are potent and commonly prescribed antiviral agents used in combination therapy (CART) of human immunodeficiency virus type 1 (HIV-1) ...CART. ...
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Reduced Fitness in Cell Culture of HIV-1 with Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Mutations Correlates with Relative Levels of Reverse Transcriptase Content and RNase H Activity in Virions
... Construction of expression plasmids for NNRTI-resistant mutants. The full- length wild-type and mutant RT sequences were amplified by PCR using pRHA and the following primers: GATATACATATGCCCATTAGTCCTATTGAG (forward) and ...
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Phylogenetic and Genetic Analysis of Feline Immunodeficiency Virus gag, pol, and env Genes from Domestic Cats Undergoing Nucleoside Reverse Transcriptase Inhibitor Treatment or Treatment-Naïve Cats in Rio de Janeiro, Brazil
... The infection in domestic cats is characterized by a long period without symptoms, followed by increased susceptibility to opportunistic infections leading to AIDS-like disease. A vaccine based on subtypes A and D was ...
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Role of etravirine in the management of treatment-experienced patients with human immunodeficiency virus type 1
... non-nucleoside reverse transcriptase inhibitor (NNRTI) with expanded antiviral activity against NNRTI-resistant HIV-1, to be used in combination therapy for treatment-experienced ...
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"A REVIEW ON PATHOLOGY OF AIDS AND ITS TREATMENT REGIMENS" by Nadeem Siddiqui*, Waquar Ahsan, Priya Ahuja, M. Shamsher Alam, Anwar Habib, India.
... a reverse transcriptase inhibitor, effective against HIV and used in combination with other antiretroviral drug therapy as part of highly active antiretroviral therapy ...
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Evidence that the Human Foamy Virus Genome Is DNA
... the reverse transcriptase inhibitor 3 * -azido-3 * -deoxythymidine (AZT) suggest that reverse transcription is largely complete before extracellular virus infects new ...
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Selection of Resistance in Protease Inhibitor-Experienced, Human Immunodeficiency Virus Type 1-Infected Subjects Failing Lopinavir- and Ritonavir-Based Therapy: Mutation Patterns and Baseline Correlates
... nucleoside reverse transcriptase inhibitor (NRTI)-experienced, nonnucleoside reverse tran- scriptase inhibitor (NNRTI)-naive patients, maximal virologic response to treatment with ...
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HIV-associated cardiovascular disease: importance of platelet activation and cardiac fibrosis in the setting of specific antiretroviral therapies
... protease inhibitor (PI) ritonavir and certain other PI- based ...nucleoside reverse transcriptase inhibitor, abacavir, activate platelets, but a role for this phenomenon in clinical CVD risk ...
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Rapid and persistent selection of the K103N mutation as a majority quasispecies in a HIV1 patient exposed to efavirenz for three weeks: a case report and review of the literature
... Non-nucleoside reverse transcriptase inhibitor (NNRTI)- based highly active anti-retroviral treatment (HAART) regimens are characterized by a good tolerance of relatively low levels of adherence to ...
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Transmission of Human Immunodeficiency Virus I Drug Resistance - a Case Report. What are the Clinical Implications?
... The success of first-line antiretroviral therapy can be challenged by the acquisition of primary drug resis- tance. Here we report a case where baseline genotypic resistance testing detected resistance conferring nucle- ...
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HIV 1 Drug Resistance Mutations in Patients Failing 1st Line Therapy in a Comprehensive Care Center in Nairobi, Kenya
... nucleoside reverse transcriptase inhibitors (NRTIs) and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or a protease in- hibitor (PI), which is also known as highly active ...
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A stochastic model for internal HIV dynamics
... of Reverse Transcriptase Inhibitor drugs as inhibition rates of cell infection and Protease Inhibitor drugs as inhibition rates of infectious virus production based on the biological ...
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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ZIDOVUDINE USING SUBLIMATION TECHNIQUE
... Zidovudine belongs to a class of drugs known as nucleoside reverse transcriptase inhibitors- NRTIs. Zidovudine is used in pregnant women to prevent passing the HIV virus to the unborn baby. This medication ...
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Switch rates, time to switch, and switch patterns of antiretroviral therapy in people living with human immunodeficiency virus in Japan, in a hospital claim database
... non-nucleoside reverse transcriptase inhibitor, PI: protease inhibitor, INSTI: integrase strand transfer inhibitor, ABC: abacavir, TDF: tenofovir disoproxil fumarate, 3TC: lamivudine, ...
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AN INSIGHT TO STRUCTURAL ANALYSIS OF COUMARINS AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
... transcriptase), 1LW2 (T215Y mutant HIV-1 reverse transcriptase) macromolecules. Ligand and Macromolecule interaction studies were carried out using software VLife Molecular Design Suite 4.3.2 (VLife ...
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Volume 2 | Issue 4 - 2012
... 13. Matthews, C.Z. Woolf, E.J. Mazenko, R.S. Haddix- Wiener. H. Chavez-Eng, C.M. Constanzer, M.L. Doss, G.A. and Matuszewski. B.K. Determination of efavirenz, a selective non-nucleoside reverse ...
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Post-exposure prophylaxis for non-occupational exposure to HIV: experience in NSW one year after the introduction of the guidelines
... non-nucleoside reverse transcriptase inhibitor) administered intrapartum, followed by a single dose to the newborn infant reduced HIV transmission by almost 50 per ...
5
<p>Doravirine and Its Potential in the Treatment of HIV: An Evidence-Based Review of the Emerging Data</p>
... non-nucleoside reverse transcriptase inhibitor (NNRTI), is available as a co-formulated single-tablet regimen (STR) including lamivudine and tenofovir disoproxil fumarate (Delstrigo ™ ) and ...
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Sensitive Phenotypic Detection of Minor Drug Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
... protease inhibitor-containing regimens in 481 patients on a failing regimen containing a protease inhibitor ...analog reverse transcriptase inhibitors and one or more protease inhibitors; ...
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