Ribonucleotide reductase
Herpes simplex virus ribonucleotide reductase: expression in Escherichia coli and purification to homogeneity of a tyrosyl free radical-containing, enzymatically active form of the 38-kilodalton subunit.
... 9 0022-538X/89/093769-08$02.00/0 Copyright © 1989, American Society for Microbiology Herpes Simplex Virus Ribonucleotide Reductase: Expression in Escherichia coli and Purification to Hom[r] ...
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Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1
... mouse cells via the RHIM-containing viral protein M45/vIRA (19, 23). M45/vIRA mutant MCMV triggers programmed necrosis by inducing an interaction between RIP3 and the DNA-dependent activator of IFN regulatory factor ...
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Inhibition of allogeneic inflammatory responses by the Ribonucleotide Reductase Inhibitors, Didox and Trimidox
... by ribonucleotide reductase. Inhibition of ribonucleotide reductase results in reduced DNA synth- esis and cell cycle arrest ...made ribonucleotide reductase inhibitors ...
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Identification and separation of the two subunits of the herpes simplex virus ribonucleotide reductase.
... 1177 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The herpes simplex virus ribonucleotide reductase is associated with two viral proteins which are both immunoprecip[r] ...
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Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase
... (ribonucleotide reductase inhibitor) and 5-fluorouracil (thymidylate synthase inhibitor) were compared with novel members of these two drug families in the treatment of a chemoresistant pancreatic cancer ...
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Vaccinia virus-encoded ribonucleotide reductase: sequence conservation of the gene for the small subunit and its amplification in hydroxyurea-resistant mutants.
... A mixed oligonucleotide probe for the VV M2 gene was designed based on an examination of the predicted amino acid sequences of four ribonucleotide reductase small-subunit proteins: Esche[r] ...
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Induction of a new ribonucleotide reductase after infection of mouse L cells with pseudorabies virus.
... Activity of ribonucleotide reductase in partially purified extracts from infected 0 and exponentially growing uninfected x cells assayed in the presence of A dTTP and B dATP.. All incuba[r] ...
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Nonself Recognition Through Intermolecular Disulfide Bond Formation of Ribonucleotide Reductase in Neurospora
... I ribonucleotide reductase (RNR) and is therefore the only described example of an RNR large subunit having nonself recognition function (Smith et ...
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Aberrant Methylation of Ribonucleotide Reductase Subunit M2 Is Closely Associated with Oral Cancer
... drug Ribonucleotide reductase (RR) is constitutively alteration in RRM2 expression leads to tumour initiation present in all dividing cells, which is involved in and progression, suggesting its possible ...
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<p>Ribonucleotide reductase subunit M2 as a novel target for clear-cell renal cell carcinoma</p>
... Ribonucleotide reductase (RNR) is an enzyme that catalyzes the rate-limiting step of de novo biosynthesis of dNTPs, which plays a critical role in genome ...
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Original Article Ribonucleotide reductase small subunit M2 expression and its clinical significance in lung adenocarcinoma tissues
... Received March 28, 2016; Accepted July 13, 2016; Epub September 1, 2016; Published September 15, 2016 Abstract: Lung cancer is one of the most lethal cancers worldwide. At present, cancer cells metastasis becomes the hot ...
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The PK Domain of the Large Subunit of Herpes Simplex Virus Type 2 Ribonucleotide Reductase (ICP10) Is Required for Immediate-Early Gene Expression and Virus Growth
... The large subunit of herpes simplex virus (HSV) ribonucleotide reductase (RR), RR1, contains a unique amino-terminal domain which has serine/threonine protein kinase (PK) activity. To examine the role of ...
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Expression of an Altered Ribonucleotide Reductase Activity Associated with the Replication of Murine Cytomegalovirus in Quiescent Fibroblasts
... Ribonucleotide reductase (RNR) is an essential enzyme for the de novo synthesis of both cellular and viral DNA and catalyzes the conversion of ribonucleoside diphosphates into the corresponding ...
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Ataxia telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis
... of ribonucleotide reductase (RR), the rate-limiting enzyme in the de novo synthesis of deoxyribonucleoside triphosphates, and control of mitochondrial homeo- ...
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Deletion of the varicella-zoster virus large subunit of ribonucleotide reductase impairs growth of virus in vitro.
... We conclude that the VZV ribonucleotide reductase large subunit is not essential for virus infection in vitro; however, deletion of the gene impairs the growth of VZV in cell culture and[r] ...
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Regulators of ribonucleotide reductase inhibit Ty1 mobility in saccharomyces cerevisiae
... Results: In this study, we identified two host genes that when deleted allow for high temperature Ty1 mobility: RFX1 and SML1. The protein products of these genes are both negative regulators of the enzyme ...
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The Epstein-Barr Virus (EBV) Deubiquitinating Enzyme BPLF1 Reduces EBV Ribonucleotide Reductase Activity
... A newly discovered virally encoded deubiquitinating enzyme (DUB) is strictly conserved across the Herpes- viridae. Epstein-Barr virus (EBV) BPLF1 encodes a tegument protein (3,149 amino acids) that exhibits ...
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Ribonucleotide Reductase as a Target to Control Apicomplexan Diseases
... Malaria is caused by species in the apicomplexan genus Plasmodium, which infect hundreds of millions of people each year and kill close to one million. While malaria is the most notorious of the apicomplexan-caused ...
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Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase.
... Taken together, the increased induction of ribonucleotide reductase activity and the enhanced synthesis of a 34,000-MW protein by all HU-resistant isolates examined suggests that this pe[r] ...
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Vaccinia virus induces ribonucleotide reductase in primate cells.
... DNA polymerase and ribonucleotide reductase activities in cellular subfractions of uninfected and vaccinia virusinfected BSC-40 cellsa Activity Fraction Sp act cpm BSC- Vaccinia virus Va[r] ...
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