Sepsis and organ dysfunction
Organ dysfunction as a new standard for defining sepsis
... definitions, Sepsis-3 is based on organ dysfunctions and uses a sequential organ failure (SOFA) score as an ...to Sepsis-3 will inevitably represent a different population than those ...
6
Circulating nucleosomes as a predictor of sepsis and organ dysfunction in critically ill patients
... lack of a group of patients only with sepsis made it unclear whether the increased levels of nucleosomes resulted from sepsis or organ dysfunction. Furthermore, a correction for multiple ...
7
Procalcitonin and C reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction
... the sepsis and systemic inflammatory response, ...and organ dys- ...severe sepsis, and organ dysfunction, PCT has demonstrated itself to be a parameter with a wide range of ...
9
Histopathological changes of organ dysfunction in sepsis
... Conclusions In conclusion, the study of histopathological changes in sepsis is of utmost importance to better understand the pathogenesis of organ dysfunction. Although the few identified studies on ...
15
The effect of diabetes mellitus on organ dysfunction with sepsis: an epidemiological study
... for organ dysfunction as a ...in organ dysfunction between patients with and without DM and ...acute organ dysfunction is crucial to improve our understanding of the mechanisms ...
6
Year in review 2010: Critical Care multiple organ dysfunction and sepsis
... in organ dysfunction, as well as genetic factor contribution, from clinical and experimental studies that were published in 2010 in Critical Care in the fi elds of multiple organ dysfunction ...
6
The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
... severe sepsis enrolled in the PROWESS trial [36], the current report includes the largest cohort of sepsis patients ana- lyzed to date for soluble markers of endothelial activa- ...of organ ...
12
Plasma procalcitonin concentrations predict organ dysfunction and outcome in dogs with sepsis
... In the present study, PCT concentrations at the time of presentation were not prognostic. This finding may result from an inherent limitation in the discriminant ability of PCT in canine sepsis. It might also be ...
9
Editorial: Translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma
... Into Organ Dysfunction authors concluded that their approach provided evidence for genetically determined variability in both leucocyte and endothelial responses, which may contribute to explaining ...
6
Circulating cell death biomarker TRAIL is associated with increased organ dysfunction in sepsis
... with organ dysfunction and with a key protein related to necroptosis, ...in sepsis and whether such a phenotype is mal- ...of sepsis and in different settings will be invaluable before ...
10
Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis
... Conclusions In the present study, we have shown that patients with sepsis undergo widespread changes in the methylome of their circulating monocytes in parallel with the acquisi- tion of endotoxin tolerance. ...
18
Use of SOFA (Sequential Organ Failure Assessment) Scoring in Assessing the Incidence and Severity of Organ Dysfunction and Predicting the Outcome in Patients with Sepsis in Surgical Unit
... (SEQUENTIAL ORGAN FAILURE ASSESSMENT) SCORING IN ASSESSING THE INCIDENCE AND SEVERITY OF ORGAN DYSFUNCTION AND PREDICTING THE OUTCOME IN PATIENTS WITH SEPSIS IN SURGICAL UNIT” is being ...
94
Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction
... non-pulmonary organ dysfunction, and mortality in a cohort of critically ill patients with ...non-pulmonary sepsis, suggesting that degradation of the glycocalyx is more severe in patients with ...
9
Multimorbidity states associated with higher mortality rates in organ dysfunction and sepsis: a data driven analysis in critical care
... limitations to using the Angus criteria in our study to identify sepsis in patients. This system relies on ICD codes to establish co-occurrence of infection and organ dysfunction. Although imperfect, ...
11
Improving documentation and coding for acute organ dysfunction biases estimates of changing sepsis severity and burden: a retrospective study
... acute organ dysfunction by virtually any ...of organ dysfunction codes for clinical markers of organ dysfunction for each calendar ...acute organ dysfunc- tion has changed ...
11
Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock
... severe sepsis and septic shock, rather than a terminal or irreversible event fol- lowing inflammation and coagulopathy ...and organ dysfunction scores averaged over 72 hours by lactate clearance ...
11
Comparative Analysis of Apache-II Score and Sofa Score as Predictors of Mortality in Patients admitted with Sepsis and Multi Organ Dysfunction Syndrome
... LITERATURE SEPSIS Sepsis is a clinical syndrome that occurs as a complication of a serious infection and it has a significant associated morbidity and ...Severe sepsis can result in a condition ...
146
Rs1800625 in the receptor for advanced glycation end products gene predisposes to sepsis and multiple organ dysfunction syndrome in patients with major trauma
... of sepsis met the criteria recommended by the American College of Chest Physicians and Society of Critical Care Medicine Consensus Conference ...Multiple organ dysfunction scores were calculated as ...
7
Levosimendan for the prevention of acute organ dysfunction in sepsis
... beneficial effect of levosimendan in any of these prespecified subgroups. Although levosimendan does not stimulate β-adrenoreceptors, a significantly higher heart rate was seen in the levosimendan group than in the ...
12
Bench to bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?
... changes in pathways that lead to release of NO; and/or changes in mechanisms that participate in subsequent degra- dation of NO. In healthy volunteers, even brief exposure to endotoxin or certain cytokines impairs ...
9