Sex Hormone Binding Globulin Level

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Correlation between the Sex Hormone Binding Globulin Level and level of Insulin Resistance in Obese Prepubertal Children

Correlation between the Sex Hormone Binding Globulin Level and level of Insulin Resistance in Obese Prepubertal Children

I declare that this dissertation entitled "CORRELATION BETWEEN THE SEX HORMONE BINDING GLOBULIN LEVEL AND LEVEL OF INSULIN RESISTANCE IN OBESE PREPUBERTAL CHILDREN” has been conducted by me at the Institute of Child Health and Hospital for Children, under the guidance and supervision of my unit chief Prof.K.R.Ravindran M.D., D.C.H., and Dr. P.G. Sundararaman M.D., DM., Lecturer, Department of Endocrinology, Institute of Obstetrics and Gynaecology, Madras Medical College, Chennai. It is submitted in part of fulfillment of the award of the degree of M.D (Pediatrics) for the September 2006 examination to be held under The Tamil Nadu Dr.M.G.R Medical University, Chennai. This has not been submitted previously by me for the award of any degree or diploma from any other university.
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Sex hormone binding globulin as a valuable biochemical marker in predicting gestational diabetes mellitus

Sex hormone binding globulin as a valuable biochemical marker in predicting gestational diabetes mellitus

Patients with GDM have a lower circulating level of SHBG than normal glucose tolerance pregnant women. Circulating concentrations of SHBG represent a poten- tially useful new biomarker identifying GDM beyond the currently established biochemical markers. A standard assay for serum SHBG analyses and a gestational trimes- ter threshold level have to be determined.

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Original Article Association between sex hormone binding globulin gene polymorphism and type 2 diabetes mellitus

Original Article Association between sex hormone binding globulin gene polymorphism and type 2 diabetes mellitus

SPSS 21.0 statistical software was used for data processing. The data were represented as mean ± standard deviation (SD) if the data were normally distributed, and the data that were not normally distributed were expressed as median and interquantile range. The differ- ence between the two groups was analyzed using t-test or rank sum test. The enumeration data were compared using Chi-square test. Comparisons among multiple groups were car- ried out using analysis of variance. The corre- lation between the variables was analyzed by non-parametric Spearman’s rank correlation analysis, and multivariate logistic regression analysis was used to analyze the risk of T2DM. The significance level was set as α = 0.05, and the difference was considered significant when P < 0.05.
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Human sex hormone–binding globulin variants associated with hyperandrogenism and ovarian dysfunction

Human sex hormone–binding globulin variants associated with hyperandrogenism and ovarian dysfunction

half-life. Her sister’s serum SHBG level (30 nmol/l) was only just within the normal female reference range, but at the time of blood sampling she was tak- ing an oral contraceptive formulation that increases serum SHBG levels (35). This would be consistent with our findings that a cDNA representing the vari- ant allele she inherited from her father is incapable of producing SHBG in CHO cells. It is also in line with previous observations that carboxy-terminal trunca- tion mutants of rat ABP are not secreted when expressed in mammalian cells (18). However, mutant mRNAs that contain a frame-shift are known to undergo rapid degradation via a nonsense-mediated decay pathway (36), and this could also account for a lack of SHBG production from the proband’s pater- nal SHBG allele. Although we have only detected this particular variant SHBG allele in the proband’s imme- diate family, it is a null allele, and it will be important to screen other populations to determine whether individuals homozygous for this allele exist.
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Common genetic variants in the sex hormone-binding globulin (SHBG) gene in idiopathic recurrent pregnancy loss: a case control study

Common genetic variants in the sex hormone-binding globulin (SHBG) gene in idiopathic recurrent pregnancy loss: a case control study

Results: Of the seven tested SHBG SNP, lower MAF of rs6257 was seen in RPL cases than in control women, which was linked with lower risk of RPL, after controlling for key covariates. At the genotype level, significantly higher frequencies of heterozygous rs858521 and rs6259, and homozygous rs858521 genotype carriers, and reduced frequency of heterozygous rs6257 and homozygous rs6257 and rs6259 genotype carriers were seen in RPL cases vs. control women, respectively. Univariate regression analysis confirmed the positive association of rs858521 and rs6259 with RPL. Multivariate regression analysis confirmed the positive association of rs858521 heterozygote and homozygote genotypes with RPL; only heterozygous rs6259 remained associated with RPL. Haploview analysis demonstrated marked linkage disequilibrium among 6 of the 7 tested SHBG SNP. Of the possible 6-locus haplotypes, 12 were common, and were included in subsequent analysis. Within these haplotypes, only increased frequency of CCGTGA haplotypes was seen in RPL cases, thus conferring RPL susceptibility.
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SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN

SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN

Conditions of hypoandrogenism in men have been linked to insulin resistance, suggesting that alterations in normal sex steroid physiology could play a role in the pathogenesis of type 2 diabetes (T2DM). Sex hormone binding globulin gene polymorphisms may be the cause of sex steroid alteration The aim of this work to study effect of sex hormone binding globulin (SHBG) gene polymorphisms on type 2 diabetes mellitus risk through its impact on testosterone and estradiol level in Egyptian men. In 185 diabetic men and 120 matched healthy controls, two polymorphisms (rs6257 and rs6259) of the gene encoding sex hormonebinding globulin were genotyped and serum levels of sex hormonebinding globulin, testosterone and estradiol were measured by ELISA; Our results showed significant decrease in sex hormone binding globulins in type 2 diabetic patients compared with the control group. Carrier of variant allele of SHBG single nucleotide polymorphism (SNP) rs6259 had a higher level of SHBG in serum (p=0.000) While carrier of SHBG rs6257 SNP had a lower level of SHBG level in serum SHBG gene polymorphisms are associated with risk of type 2 diabetes in Egyptian men, through lowering circulating levels of sex hormonebinding globulin and consequently lowering testosterone and elevating estradiol level. SHBG rs6257 genotype may have a predictive value of developing type II diabetes mellitus
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Effect of Endurance and Resistance Training on Parameters Related to Sexual Function in Men

Effect of Endurance and Resistance Training on Parameters Related to Sexual Function in Men

Background and Objective: The hormonal responses are different, according to type, intensity and the duration of training. We aimed to compare the effect of endurance and resistance training in untrained men on the level sexual hormone including testosterone, estradiol, and on sex hormone binding globulin (SHBG).

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Inverse Relationship between Hepatic Steatosis and Alanine Aminotransferase with Sex Hormone Binding Globulin in Men

Inverse Relationship between Hepatic Steatosis and Alanine Aminotransferase with Sex Hormone Binding Globulin in Men

Multivariable logistic regression was used to assess the as- sociation of ALT elevation with risk of low SHBG. We adjusted for age, BMI, systolic blood pressure (SBP), diastolic blood pres- sure (DBP), WBC, glucose, T3, total cholesterol, HDL, and TG. To investigate the interrelationships among hepatic steatosis, elevated ALT levels, and risk of low SHBG, we divided our par- ticipants into the following three groups: a reference group of participants who had no hepatic steatosis and no ALT eleva- tion, the hepatic steatosis group without ALT elevation, and the hepatic steatosis with ALT elevation group. The effect of inter- actions between hepatic steatosis and ALT on the risk of lower SHBG level was examined by multivariate logistic regression. Results are expressed as odds ratios (ORs) with 95% confidence intervals (CIs). All analyses were performed using SPSS soft- ware (version 18.0, SPSS Inc., Chicago, IL, USA). All statistical tests were two-sided and significance was determined at a p- value<0.05.
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Gender-specific associations of serum sex hormone-binding globulin with features of metabolic syndrome in children

Gender-specific associations of serum sex hormone-binding globulin with features of metabolic syndrome in children

Insulin down-regulates hepatic SHBG production [19], while an inverse correlation between BMI and insulin sensitivity has been shown in various studies in obese children and adolescents [37, 38]. Our study demonstrating an inverse correlation between BMI and SHBG levels is also in accordance with previous investi- gations in children [39, 40]. Krishnasamy and colleagues demonstrated an inverse relation between SHBG levels and waist circumference, as well as body mass index percentile in children at risk for MetS [23]. Our study partially supports the above results showing a signifi- cant inverse correlation between SHBG levels and waist circumference but only in boys. There is evidence show- ing an inverse association between SHBG, BP and TG in adults and children [40, 41]. The studies also observed a direct association of SHBG with HDL-c level. Our study supports the above results showing a significant inverse correlation between SHBG, systolic BP and TG levels and a direct relation between SHBG with HDL-c levels in the MetS group including boys and girls. The lowest tertile of SHBG level showed a higher prevalence of MetS in boys, with a uniform inverse trend than girls. The possible explanation for this trend may the corre- lation of SHBG level with more MetS components as compared to girls. The ROC analysis also supports the above trend which shows SHBG as a clearer predictor of MetS components in boys than girls.
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Role of sex hormone binding globulin as the early predictor for gestational diabetes mellitus

Role of sex hormone binding globulin as the early predictor for gestational diabetes mellitus

Hyperbilirubinemia occurs due to the increased production and decreased life span of RBC’s with glycosylated cell membranes. Women with normal fasting and elevated postprandial blood sugar values are having the infants at increased risk of hyperbilirubinemia. In the current study [Table 14]. The significant between the higher bilirubin level and GDM was proved when compared to other study which also showed the same findings. 22

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Associations of sex hormone-binding globulin and testosterone with diabetes among men and women (the Saku Diabetes study): a case control study

Associations of sex hormone-binding globulin and testosterone with diabetes among men and women (the Saku Diabetes study): a case control study

The height (cm) and weight (kg) of the subjects were measured with an automatic scale (Tanita, BF-220, Tokyo, Japan), in light clothing. The body mass index (BMI) was calculated as the weight (kg) divided by the squared height (m 2 ). Waist circumference was measured twice at the umbilicus level while the subject was in a standing position using a fiberglass measuring tape; the average measurement was used for the analysis. Blood pressure was measured while the subject was in a sitting position using a validated automated blood pressure monitor (ES-H55; Terumo, Tokyo, Japan). The physical activity levels were obtained by asking the participants about their average frequency of physical activity: rarely/ never, 1 to 3 times per month, 1 to 2 times per week, and more than 3 times per week.
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A Study on Insulin Resistance and Obesity Among Women at High Risk for Breast Cancer Using Cluster Analysis.

A Study on Insulin Resistance and Obesity Among Women at High Risk for Breast Cancer Using Cluster Analysis.

Skin- fold measurements technique is the simplest method for measuring body fat percentage and the results are obtained according to specific tables. Waist Circumference (WC) provides important information about the accumulation and distribution of the body fat. More specifically, it is considered an adequate tool for assessing central obesity. Also, the ratio of Waist to Hip (WHR) is another easy method for assessing central obesity. WHR is defined as the ratio between the lower part of the crest of the iliac ala and the perimeter of the hips, measured at the level of trochanters.
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Studies on Human Thyroxine Binding Globulin: VI  THE NATURE OF SLOW THYROXINE BINDING GLOBULIN

Studies on Human Thyroxine Binding Globulin: VI THE NATURE OF SLOW THYROXINE BINDING GLOBULIN

A model system utilizing a highly purified partially desialylated thyroxine-(T 4 ) binding protein (STBG) was studied. STBG was prepared by the same affinity chromatographic method we have reported for preparation of highly purified T 4 -binding globulin (TBG). The necessary prerequisite for preparation of STBG was the use of T 4 -substituted Sepharose which had been repeatedly exposed to large volumes of serum for purification of TBG. STBG moved more slowly on cellulose acetate electrophoresis than TBG but had the same molecular weight and antigenic determinants as TBG. It bound T 4 with a 1: 1 molar ratio but its affinity for T 4 was about 10 times less than that of TB. STBG had about onefourth the sialic acid content of TBG and the electrophoretic mobility of this protein was similar to that of a T 4 -binding protein with a mobility slower than that of TBG which has been seen in the electrophoretic patterns of some normal human serums and in serums of patients with hepatic cirrhosis and which does not appear to be an artifact caused by storage and
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Evaluation of the hypothalamic–pituitary–adrenal axis in a case series of familial partial lipodystrophy

Evaluation of the hypothalamic–pituitary–adrenal axis in a case series of familial partial lipodystrophy

AACE: American Association of Clinical Endocrinologists; ACTH: adrenocor- ticotrophic hormone; BMI: body mass index; BAI: body adiposity index; CBG: cortisol-binding globulin; CS: Cushing syndrome; DEX: dexamethasone; DXA: dual X-ray energy absorptiometry; FMR: fat mass ratio; FPL: familial partial lipodystrophy; HBP: high blood pressure; HOMA-IR: homeostatic model assessment of insulin resistance; HPA: hypothalamic–pituitary–adrenal axis; HPLC: high-performance liquid chromatography; IR: insulin resistance; PCOS: polycystic ovary syndrome; PDC: post-dexamethasone cortisol; PPARγ: peroxi- some proliferator-activated receptor gamma; TA: adipose tissue; T2D: type 2 diabetes; UFC: urinary free cortisol; WC: waist circumference; WHR: waist-to-hip ratio; 11βHSD1: 11β-hydroxysteroid dehydrogenase type 1.
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Measurement of tissue cortisol levels in patients with severe burns: a preliminary investigation

Measurement of tissue cortisol levels in patients with severe burns: a preliminary investigation

Microdialysis is an in vivo sampling technique for measuring endogenous and exogenous solutes in the extracellular space of tissue. A small probe equipped with a semi-permeable hol- low fibre is inserted superficially into the dermis, and perfused with a solution that forms an equilibrium with diffusible mole- cules in the immediate surroundings [14]. Microdialysis tech- niques have recently been used to investigate interstitial cortisol concentrations (which are largely free) [15], thus allowing comparison with plasma values. Although routine measurement of tissue hormone concentrations may not be practical in the clinical setting, the assessment of a relation between plasma and interstitial concentrations may allow us to develop predictive models for tissue cortisol concentrations from plasma measurements.
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Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens

Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens

BACKGROUND: Epidemiological studies have shown that both the estrogen dose and progestogen type of oral contraceptives contribute to the increased risk of thrombosis in oral contraceptive users. Thrombin generation- based activated protein C (APC) sensitivity is a global test for the net prothrombotic effect of oral contraceptives and predicts the thrombotic risk. Our objective was to test the usefulness of sex hormone-binding globulin (SHBG) as a marker for the thrombotic risk of an oral contraceptive. METHODS: We measured SHBG and APC resist- ance in 156 healthy users of various types of oral contraceptives. RESULTS: Users of oral contraceptives with a moderately increased risk of thrombosis (gestodene and desogestrel pills) had higher SHBG levels than users of low-risk oral contraceptives containing levonorgestrel. Similarly, for higher doses of estrogen in oral contraceptives we found higher SHBG levels. Women using oral contraceptives with the highest thrombotic risk (cyproterone acetate pills) rendered the highest SHBG levels. Users of oral contraceptives containing gestodene, desogestrel or cyproterone acetate were more resistant to APC than users of levonorgestrel pills. SHBG levels were positively associated with the increased APC resistance. CONCLUSIONS: Our findings support the hypothesis that the effect of an oral contraceptive on SHBG levels might be a marker for the thrombotic risk.
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Androgènes et sexualité masculine

Androgènes et sexualité masculine

: Relationships of plasma estradiol, testoste- rone, and sex hormone-binding globuline with lipo- proteine, apolipoproteine and high density lipopro- teine subfractions in m[r]

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The effect of omega-3 supplementation on androgen profile and menstrual status in women with polycystic ovary syndrome: A randomized clinical trial

The effect of omega-3 supplementation on androgen profile and menstrual status in women with polycystic ovary syndrome: A randomized clinical trial

35 women for each group were estimated. Then we added 20% to this number, so 39 people for each group were included in the analyses. Individuals were eligible for participation if they were aged 20-40 years, have body mass index of over 25, and met the Rotterdam criteria for PCOS. The PCOS diagnostic criteria were oligoovulation or anovulation, the clinical symptom of hyperandrogenism or the presence of hyperandrogenemia, and diagnosis of polycystic ovaries using ultrasound. The women who were menopause, consumed omega-3 in the last 3 months, used tobaccos, were diabetic or hypothyroidism, followed a special diet or consumed effective drugs on hormonal profile like oral conceptives (OCP), glucocorticoids, ovulation induction agents, anti-obesity, antidiabetic, antihypertensive medicine, estrogenic, antiandrogenic, anticoagulants and antidepressants, in the last 3 months before enrollment were excluded. If patients need treatment with OCP, they were excluded from the study. Because of difference in hormone profile status between menopause and menstruation, menopausal women excluded from the study.
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Sex Hormone Binding Globulin as a Predictor of in Vitro Fertilization Outcomes in Polycystic Ovary Syndrome: Our Results

Sex Hormone Binding Globulin as a Predictor of in Vitro Fertilization Outcomes in Polycystic Ovary Syndrome: Our Results

Objectives: in case of Polycystic Ovary Syndrome (SOPK), predicting ovarian response before un- dertaking risky in vitro fertilization (IVF) proceeds is crucial. Sex Hormone Binding Globulin (SHBG) is introduced in literature as an interesting indicator of follicle’s maturation and quality. The aim of this study was to investigate whether serum SHBG levels are related to fertilization outcomes in SOPK women undergoing IVF procedures. Methods: in a prospective cohort study, we enrolled 61 SOPK women and 91 matched group of infertile women. All of them were undergoing FIV/ICSI proceeds. SHBG levels were performed in peripheral blood samples as well as others hormones determination. Results: we noted significant differences between our study group of SOPK patients and the Control group concerning the characteristics of the ovarian response to gonadotrophins administration and concerning the profile of biological proceeds’ outcomes. But no significant correlation between SHBG and FIV/ICSI outcomes was found either in SOPK or in Control group. Conclusions: our study provides evidence that SHBG can’t be considered as a pre- dictor of IVF outcomes because production of this steroid-binding protein depends on many pa- rameters such as metabolic disorders frequently associated with SOPK.
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CAPACITY OF THYROXINE-BINDING GLOBULIN TO BIND TRIIODOTHYRONINE AND THYROXINE IN MATERNAL AND CORD BLOOD

CAPACITY OF THYROXINE-BINDING GLOBULIN TO BIND TRIIODOTHYRONINE AND THYROXINE IN MATERNAL AND CORD BLOOD

The binding capacity of plasma is ac tually measured by determining the quan tity of added labeled hormone necessary to saturate the binding sites of the interaipha globulin (the thyroxi[r]

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