small interference RNA
Effect of small interference RNA (siRNA) for ADAMTS5on intervertebral disc degeneration in the rabbit anular needle puncture model
... Introduction The etiology of degenerative disc disease is unknown. Several investigators have reported the presence of proteolytic enzymes, such as the matrix metalloproteinase (MMP) and ADAMTS (a disintegrin and ...
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Bcr-abl Silencing by Specific Small-Interference RNA Expression Vector as a Potential Treatment for Chronic Myeloid Leukemia
... Background: RNA interference (RNAi) is the mechanism of gene silencing-mediated messenger RNA degradation by small interference RNA (siRNA), which becomes a powerful tool for in ...
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Inhibition of full length Hepatitis C Virus particles of 1a genotype through small interference RNA
... RNA interference (RNAi), a post-transcriptional regu- lation mechanism, is initiated by small interfering RNAs (siRNAs) of 21-23 nucleotides, which are incorporated into a multi-protein complex ...
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Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus
... of small interfering RNAs (siRNAs) libraries that specifically target human genes important for endocytosis processes, trafficking of mem- brane vesicles, actin polymerization and cytoskeleton rearrangement to ...
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Small interference RNA targeting tissue factor inhibits human lung adenocarcinoma growth in vitro and in vivo
... by small interfering RNA (siRNA) in Lung adenocarcinoma. RNA interference (RNAi) is sequence-specific post-transcriptional gene- silencing process, which is initiated by double-stranded ...
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Post transcriptional inhibition of hepatitis C virus replication through small interference RNA
... NS5B RNA dependent RNA polymerase and NS4B genes showed a dramatic reduction in HCV viral RNA, NS4Bsi- 166 and NS5Bsi-1064 exhibited maximum inhibition up to 90% at a 20 μM ...
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The inhibitory effect of small interference RNA protein kinase C-alpha on the experimental proliferative vitreoretinopathy induced by dispase in mice
... Due to the limitation of the PKC α inhibitor, siRNA is a very popular method for inhibiting the PKC α . Instability is a major obstacle in RNA therapeutic applications. Without any chemical modification, the siRNA ...
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Original Article TFF3 knockout in human pituitary adenoma cell HP75 facilitates cell apoptosis via mitochondrial pathway
... by small interference RNA (siRNA), in order to investigate the effect of TFF3 knockdown on cell apoptosis, along with the elucidation of apoptotic regula- tory ...
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Vol 70, No 4 (2018)
... Despite the importance of PCD in the development of colon cancer, studies are limited and controversial. Past work has simultaneously and quantitatively ana- lyzed both apoptotic and autophagic pathways in clini- cal ...
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Trimethylation of Histone H3 Lysine 4 by Set1 in the Lytic Infection of Human Herpes Simplex Virus 1
... Using small interference RNA, we found that the reduction of Set1, but not Set7/9, reduces the transcription and replication of HSV-1 and specifically decreases H3K4me3 on the virus ...
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Inhibition of Monkeypox virus replication by RNA interference
... of RNA interference pathway (RNAi) as a therapeutic approach for orthopox virus infections using MPV as a ...by small interference RNA ...
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BmICE-2 interference vector construction and its silencing effect in the BmN-SWU1 cells
... The miRNA expression vector in this study used the silkworm miRNA bmo-mir-273a as the basic backbone structure and PIZ/V5-BmICE-2-miRNA-dsRed as the interference vector. This expression vector effectively silenced ...
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Mcl 1 confers protection of Her2 positive breast cancer cells to hypoxia: therapeutic implications
... Methods: RNA interference and a novel small molecule inhibitor, EU-5346, were used to examine the role of Mcl-1 in Her2-positive BC cell lines and primary BC cells (sensitive or intrinsically ...
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Inhibition of Gammaherpesvirus Replication by RNA Interference
... 21-nt RNA oligonucleotides were purchased from Dharmacon Research, ...and RNA duplexes were prepared according to the manufacturer’s rec- ...annealed RNA duplexes ...with RNA duplexes plus ...
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RNA Interference (RNAi) Screening in Drosophila
... full RNA-induced silencer complex (RISC) is ...Endogenous small RNAs such as micro RNAs (miRNAs) use similar and divergent pathways to si- lence gene expression [reviewed in Chapman and Carrington ...
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Engineering Ligand Control of RNA Interference
... of RNA-based gene regulation in mammalian cells based on synthetic ligand-responsive ...into RNA-based ligand control systems (Barrick and Breaker, ...within RNA-based regulatory systems to identify ...
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RNA Interference: An Evolutionary Pathway in Periodontal Tissue Engineering
... double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing regulates the expres- sion of protein-coding ...
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<p>Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers</p>
... non-coding RNA; SNHG5, small nucleolar RNA host gene 5; ncRNA, non-coding RNA; miRNA, microRNA; siRNA, small interfering RNA; tRNA, transfer RNA; rRNA, ribosomal ...
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Modulation of Flavivirus Population Diversity by RNA Interference
... Thus, the results of this study reveal for the first time, a mech- anism by which the innate immune system directly influences quasispecies diversity of an RNA virus. In light of the controversy surrounding two ...
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Investigation of the RNA-interference pathway of Toxoplasma gondii
... the RNA polymerase II transcribes a pre-mRNA, there are many steps of mRNA processing before a mature mRNA is ready for ...Messenger RNA processing allows for proper stability and translation of ...
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