Solid product
Synthesis, Spectral Behavior and Biological Activity of Some New Fused/Isolated Polyfunctionally Heterocyclic Compounds
... Equimolar ratios of ethanolic solution 1 (0.01mol) and benzylidene malononitrile (0.01mol) in the presence of triethylamine as catalyst was refluxed for 5h. The reaction mixture was filtered, cooled and solid ...
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Vol 3, No 9 (2014)
... To a solution of compound 1 (0.5 g, 1.52 mmol) in ethanol (10 mL), hydrazine hydrate (98 %, 1.52 mmol) was added, and the reaction mixture was heated under reflux for 2 h. The solvent was then evaporated under reduced ...
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Vol 2, No 8 (2013)
... To a suspension of either 3a (0.53 g, 0.002 mol) or 3b (0.59 g, 0.002 mol) in sodium ethoxide solution [prepared by dissolving sodium metal (0.046 g, 0.002 mol) in absolute ethanol (50 ml)], malononitrile (4a) (0.132 g, ...
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Nitriles in Heterocyclic Synthesis: Synthesis of Pyrido[3’,2’:4,5]Thieno[2,3 d] Pyrimidines Derivative
... The solid product formed after cooling was collected by filtra- tion and recrystallized from acetic acid as yellow crystals; mp > 350 ˚C; yield 50%; IR v cm −1 3450 - 3195 (NH), 2220 (CN), 1670 (CO); 1 H ...
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Synthesis of Some Quinazoline Derivatives Functionalized with3-Heterocycles Side Chain
... carbonitrile (3): To a stirred solution of 2 (0.01 mol) in dimethyl formamide (20 ml) at room temperature, phenyl isothicyanate (0.01 mol) and catalytic amount of potassium hydroxide were added. The stirring is continued ...
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Vol 3, No 7 (2014)
... A mixture of 4-((4,5-diphenyl-1H-pyrazolo[3,4- c]pyridazin-3-yl)diazenyl)-3-methyl-1-phenyl-1H-pyrazol- 5(4H)-one 8 (0.5g, 1.05 mmol) and phosphorylchloride (25 mL) was refluxed for 3h. The reaction mixture was cooled to ...
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Vol 2, No 9 (2013)
... A mixture of malononiltrile (0.66 g; 0.01 mol), 2- acetylnaphthalene (1.7 g; 0.01 mol), 3,4,5- trimethoxybenzaldehyde (1.96 g; 0.01 mol) and ammonium acetate (1.15 g; 0.015 mol) in dry benzene (50 ml) was heated under ...
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Synthesis and characterization of chiral imidazolinones
... in The Adduct and ethylimidate ethyl ester CH2C12 After stirring for 2 white solid product was separated 20 ml days, by the suction recovered product was negligible.. The melting and vap[r] ...
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A Simple and Convenient Synthesis of Isolated Fused Heterocycles Based on: 2 Imino N phenyl 2H chromene 3 carboxamide
... General procedure: A mixture of 24a (3.66 g, 0.01 mol) and cyanoacetamide (0.84 g, 0.01 mol) in 30 ml of ethanol in the presence of 0.1 ml of piperidine was re- fluxed for 8 h. The reaction mixture was concentrated under ...
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Synthesis, Characterization and Antimicrobial Activity of Newly Substituted 3-Aroyl Flavanones
... was added slowly with constant stirring. After four hours the reaction mixture was acidified by adding ice cold dilute HCl (1:1). The solid product thus separated was filtered, washed with sodium ...
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β-Oxanilide in Heterocyclic Synthesis: Synthesis of Pyridazine, Pyrazole and Triazine Derivatives carrying Sulfonamide and Antipyrine Moieties
... A solution of each of compounds 14a,b (0.01 mole) in DMF (30 mL) containing a few drops of triethylamine was heated under reflux for 10 hrs. The reaction mixture was left to cool. Then poured into crushed ice and ...
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Synthesis and Antibacterial Screening of Novel Fluorine Containing Heterocycles
... 2-[3-(2,4-Dimethylthiazol-5-yl)-1-(4-fluorophenyl)- 1H-pyrazol-4-methylene]-benzofuran-3-one 6a-f A mixture of chalcone 3 (0.001 mol) and mercuric acetate (0.001 mol) was dissolved in 10 mL dry pyridine. The reaction ...
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Vol 7, No 9 (2018)
... from (19.724 g, 0.1 mol) p-aminoazobenzene, acetic acid and the appropriate quantities of sodium nitrite). The reaction mixture was stirred for1 h. The resulting solid product was collected by filtration, ...
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← Return to Article Details SYNTHESIS OF NOVEL 1,2-DIOL CONTAINING AZO DYES FOR POLYMERIC SUBSTRATES
... filtered. Solid product mass is then dissolved in water and extracted with dichloromethane, dried over sodium ...azo product F which was further purified by column chromatography (ethyl acetate: ...
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MODERNIZATION OF TECHNOLOGICAL LINE FOR CELLULAR EXTRUSION PROCESS
... Currently, the most significant group of po- rophors used in extrusion and injection moulding of plastics are organic porophors. They belong to a number of groups having different chemical structures. Of those, the ...
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Pharmaceutical Solid Polymorphism in Abbreviated New Drug Application (ANDA) – A Regulatory Perspective
... of product development starting from pre-clinical stages to post marketing phase of the drug ...finished product during storage, transportation and ...generic product development program for setting ...
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The Catalytic Performance of ZrO2-SO4 and Ni/ZrO2-SO4 Prepared from Commercial ZrO2 in Hydrocracking of LDPE Plastic Waste into Liquid Fuels
... the product distribution of liquid products consist of gasoline fraction (C 5 – C 12 ) in retention time range of 0 – 10 ...intermediate product as a kind of reaction in hydrocracking process more ...
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Vendor qualification: Utilization of solid state characterization “Toolbox” to assess material variability for active pharmaceutical ingredient
... drug product release is >70% in 45 minutes (single point ...drug product performance testing, these two prototypes were found to be dissimilar with respect to drug product disintegration, that is, ...
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Crosslinking with transglutaminase does not change metabolic effects of sodium caseinate in model beverage in healthy young individuals
... We included whey protein also in the study protocol to verify the differences between the two main milk pro- tein types, casein and whey protein. The most apparent differences were detected in postprandial concentrations ...
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Synthesis and Antibacterial Application of Nanosized Polyethylene oxide - Iodine Complex by Solid - Vapor Reaction
... An eco-friendly reaction between polyethylene oxide (PEO) and iodine vapor has been studied on microslide. Growth kinetics was studied by measuring an increase in weight of the material as a function of time and found to ...
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