Soluble CD4 (sCD4)
Equal levels of gp120 retention and neutralization resistance of phenotypically distinct primary human immunodeficiency virus type 1 variants upon soluble CD4 treatment.
... by soluble CD4 (sCD4), whereas primary HIV-1 variants are highly resistant to sCD4 ...of sCD4 neutralization sensitivity, and the same region has also been implicated as influencing ...
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Mapping genetic determinants for human immunodeficiency virus type 1 resistance to soluble CD4.
... Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 sCD4 neutralization differ in sCD4 binding and glycoprotein gpl20 retention from sCD4-sensitive i[r] ...
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Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates.
... 235-243 0022-538X/92/010235-09$02.00/0 Copyright X 1992, American Society for Microbiology Virions of Primary Human Immunodeficiency Virus Type 1 Isolates Resistant to Soluble CD4 sCD4 N[r] ...
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Activation of T lymphocytes in dengue virus infections High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon gamma in sera of children with dengue
... of soluble IL-2 receptor (sIL- 2R), soluble CD4 (sCD4), soluble CD8 (sCD8), interleukin-2 (IL-2) and interferon-gamma (IFN gamma) in the sera of 59 patients with DHF and 41 patients ...
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Sequential CD4-Coreceptor Interactions in Human Immunodeficiency Virus Type 1 Env Function: Soluble CD4 Activates Env for Coreceptor-Dependent Fusion and Reveals Blocking Activities of Antibodies against Cryptic Conserved Epitopes on gp120
... with CD4 and coreceptor to induce membrane fusion. Recombinant soluble CD4 (sCD4) activated fusion between effector cells expressing Env and target cells expressing coreceptor (CCR5 or CXCR4) ...
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Two mechanisms of soluble CD4 (sCD4)-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4.
... Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gpl20.. Identific[r] ...
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Effect of recombinant soluble CD4 on human peripheral blood lymphocyte responses in vitro
... recombinant soluble CD4 protein (rsT4) blocks both HIV-1 infection of CD4 bearing lymphocytes and syncytium formation in ...(Recombinant soluble CD4 is designated by ...recombinant ...
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A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells.
... Two other MAbs, OKT4 and L120, which are reactive with domains 3 and 4 of CD4, have little or no effect on HIV-1 infection, syncytium formation, or sCD4-induced conformational changes in[r] ...
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Effects of Soluble CD4 on Simian Immunodeficiency Virus Infection of CD4-Positive and CD4-Negative Cells
... of sCD4 on virus in- fection might derive from competition for cellular CD4, with a consequent decrease in virus attachment to the target cell surface, and from other disruptive effects on the structure of ...
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Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4.
... We demonstrate that, at 37°C, the affinity of the binding reaction between sCD4 and HIV-1 IIIB and RF virions is experimentally indistinguishable from that for the reaction between sCD4 [r] ...
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Neutralization of Human Immunodeficiency Virus Type 1 by sCD4-17b, a Single-Chain Chimeric Protein, Based on Sequential Interaction of gp120 with CD4 and Coreceptor
... The CD4 interaction greatly enhances bind- ing of soluble gp120 to coreceptor (2, 14, 16, 21, 22, 36, 43, ...(ii) Soluble CD4 (sCD4) induces Env to promote fusion/entry with cells ...
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Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4.
... Here we report the selection of an HIV-2 strain, LAV-2/B, which directly induces cell-to-cell fusion and efficient infection of certain CD4- human cell lines.. Other HIV-2 strains, howev[r] ...
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CD4 immunoadhesin, but not recombinant soluble CD4, blocks syncytium formation by human immunodeficiency virus type 2-infected lymphoid cells.
... Effect of rCD4, CD4-IgG, or V1V2 on syncytium formationa between C8166 cells and HIV-1-infected or HIV-2-infected H9 cells Syncytium formation enhancement of cells infected with: Inhibit[r] ...
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Increase in soluble CD4 binding to and CD4-induced dissociation of gp120 from virions correlates with infectivity of human immunodeficiency virus type 1.
... Since primary isolates do not usually replicate well in CD4+ cell lines 21, 22, 63, it is possible that the capacity for growth in such cells and the ability of the viral envelope to bin[r] ...
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Soluble CD4 enhances simian immunodeficiency virus SIVagm infection.
... 6252 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The CD4 molecule is expressed on T-helper cells and serves as the cellular receptor for the human immunodeficiency [r] ...
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Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity.
... 5007-5012 0022-538X/91/095007-06$02.00/0 Copyright © 1991, American Society for Microbiology Effects of Changes in gpl20-CD4 Binding Affinity on Human Immunodeficiency Virus Type 1 Envel[r] ...
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Increased Neutralization Sensitivity of Recently Emerged CXCR4-Using Human Immunodeficiency Virus Type 1 Strains Compared to Coexisting CCR5-Using Variants from the Same Patient
... for soluble CD4 (sCD4) and the broadly neutralizing antibodies IgG1b12, 2F5, 4E10, and 2G12 of multiple coexisting clonal R5 and (R5)X4 (combined term for monotropic X4 and dualtropic R5X4 viruses) ...
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Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site
... Viruses and reagents. HIV-1 subtype B envelope clones QH0692.42 and PVO.4, amplified from acutely infected individuals (33), were obtained from the NIH Reference and Reagent Program. The cloned subtype C envelopes COT9.6 ...
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Thesis
... of CD4. Here, we assessed the CD4 entry phenotype in conjunction with soluble CD4 sensitivity (a feature of low CD4-using Envs) to determine that the rebound viruses needed high levels ...
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Neutralization sensitivity of human immunodeficiency virus type 1 is determined in part by the cell in which the virus is propagated.
... Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gpl20.. Human imm[r] ...
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