sorting nexin (SNX)
Mapping the interactions between a RUN domain from DENND5/Rab6IP1 and sorting nexin 1
... the SNX region (72% with the PX-BAR domains), is unable to bind DENND5 ...the SNX region encodes ...a sorting nexin protein with a similar domain organization, as evidenced by GST pulldowns ...
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Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients
... The sorting nexin (SNX) family of proteins consists of a diverse group of cytoplasmic or membrane-associated mol- ecules that are characterized by the presence of a phospholipid-binding motif, the ...
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Dislich, Bastian (2011): Struktur-Funktionsanalyse der BAR Domäne von Sorting Nexin 33. Dissertation, LMU München: Medizinische Fakultät
... is sorting nexin 9 (SNX9), a member of the het- erogenous family of SNXs (19, ...an SNX-type Phox homology (PX) domain, which is a sub- group of the phosphoinositide-binding PX domain superfamily ...
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A Novel PDZ Domain Interaction Mediates the Binding between Human Papillomavirus 16 L2 and Sorting Nexin 27 and Modulates Virion Trafficking
... protein sorting nexin 27 (SNX27) shares several structural features with ...the SNX-BAR (sorting nexin with a Bin/Amphyphysin/Rvs domain)-retromer complex ...
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Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1
... mixture; SNX: Sorting nexin; SNX4: Sorting nexin-4; SNX-BAR: SNX protein containing a Bin/amphiphysin/ Rvs domain; TGN: Trans-Golgi network; VPS: Vacuolar protein ...
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Functional characterization of Arabidopsis sorting nexin AtSNX2b
... yeast sorting nexin is specifically involved in sorting of Vps10p, the receptor for the soluble vacuolar hydrolase carboxypeptidase Y (CPY), the Golgi resident membrane protein A-ALP, and ...
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Interaction of Human Cytomegalovirus Tegument Proteins ppUL35 and ppUL35A with Sorting Nexin 5 Regulates Glycoprotein B (gpUL55) Localization
... Mutagenesis of UL35. We subsequently set out to identify a UL35 mutant which is unable to interact with SNX5 to functionally analyze the consequences of the interac- tion between UL35 and SNX5. For this purpose, we ...
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Comparative Characterization of the Sindbis Virus Proteome from Mammalian and Invertebrate Hosts Identifies nsP2 as a Component of the Virion and Sorting Nexin 5 as a Significant Host Factor for Alphavirus Replication
... protein, sorting nexin 5 (SNX5), was shown to be critical for the replica- tion of three different alphaviruses, Sindbis, Mayaro, and Chikungunya ...
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Sorting nexin 9 (SNX9) is not essential for development and auditory function in mice
... endosomal sorting and signaling. As an important member of sorting nexin family, sorting nexin 9 (SNX9) has been shown to participate in coordinating actin polymerization with membrane ...
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Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
... some SNX members have been found to mediate APP processing/Aβ generation through regulating trafficking of AD associated proteins: SNX17 can interact with APP in the early endosome and downregulation of SNX17 ...
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The sorting Nexin 3 retromer pathway regulates the cell surface localization and activity of a Wnt-activated polycystin channel complex
... (NT2 or CT2) indirectly via the retromer complex. The retromer complex originally identified in yeast comprises two sub-complexes: a trimer (Vps26-29-35) which functions as a cargo-selective adaptor and a membrane ...
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Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor ß signaling
... Because SNX9 shows minimal nuclear membrane binding in the absence of TGFβ treatment Figure 5D, yet is necessary for pSmad3 nuclear trafficking Supplemental Figure S1E and Figures 2, C a[r] ...
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Dysregulation of protein trafficking in neurodegeneration
... The sorting nexin family of trafficking components com- prise 33 family members, each containing a signature lipid-binding PX domain ...5 sorting nexins have been found to regulate APP cleavage or A ...
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A potential role for protease nexin 1 overexpression in the pathogenesis of scleroderma
... Scleroderma currently affects approximately 75,000–100,000 individuals in the United States. Fibroblasts isolated from lesional skin of scleroderma patients overexpress collagens and other matrix components, and this ...
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Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma
... protease nexin 1 (PN1) and the Hh ...glial-derived nexin, is an ECM protein known to tightly bind and counter the activity of thrombin, urokinase plasminogen activator (UPA), TPA, and trypsin (22, ...
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Connexins: a myriad of functions extending beyond assembly of gap junction channels
... mark of many tumors [12]. As such, multiple human breast tumor cell lines exhibit down-regulation of con- nexin gene expression [230], and deficiency of Cx43 gap junctions is considered as a marker of breast ...
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View pdf
... In this paper we presented an algorithm built using the ideas of classical selection and insertion sorting. We proved that the new hybrid algorithm has a worst, best, and average case time complexity of √ . The ...
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VHDL Design of a Scalable VLSI Sorting Device Based on Pipelined Computation
... a sorting algorithm, aiming at defining an elementary sorting unit as a building block of VLSI devices which require a huge number of sorting ...A sorting VLSI device, in fact, can be built as ...
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Protease nexin-1 expression is altered in human breast cancer
... Regulation of extracellular uPA activity is known to occur through the inhibitory properties of type I plasminogen activator inhibitor (PAI-1), a serine protease inhibitor (SERPIN) that is synthesized and secreted often ...
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Educational Alternatives, Volume 16, 2018
... automated sorting of mail. In terms of letter sorting machines, it was implemented two models, the first model was the CRS lines (Figure 4), and the FSM model ...
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