spindle orientation
Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium
... mitotic spindle orientation and asymmetric division play a crucial role in the self-renewal/differentiation of epithelial cells, yet little is known about these processes and the molecular programs that ...
15
A default mechanism of spindle orientation based on cell shape is sufficient to generate cell fate diversity in polarised Xenopus blastomeres
... possible spindle orientations in the embryo, quantified for the 128- to 256-cell division in 10 embryos (n=447 ...of spindle orientation occur also in isolated blastomeres at 128-cell stage, as ...
11
Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe
... switch spindle orientation in neuroepithelial cells we misexpressed Insc in neuroepithelial ...whether spindle reorientation can induce a neuroblast fate in this ...mitotic spindle, we saw no ...
15
Syndecan defines precise spindle orientation by modulating Wnt signaling in C elegans
... ABar spindle orientation pathway and in parallel to ...ABar spindle (Cabello et ...division orientation defects due to knockdown of Wnt signaling, and significantly enhances defects due to ...
12
Monitoring spindle orientation: Spindle position checkpoint in charge
... Spindle orientation along the polarity axis is vital in asymmetric cell divisions to assure the outcome of the division is ...correct spindle positioning exist in higher eukaryotes ...centrosome ...
15
Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells
... the spindle along the plane of the epithelium (planar orientation) for mitosis to produce two identical daughter cells (Jaffe et ...mitotic spindle orientation during asymmetric cell division ...
11
Dynamic localization of C elegans TPR GoLoco proteins mediates mitotic spindle orientation by extrinsic signaling
... in orientation of mitotic divisions towards specific areas of the cell cortex (Grill et ...and spindle orientation, or, alternatively, whether extrinsic signals function merely as permissive cues, ...
12
Hüls, Daniela (2012): Structural and functional studies on mitotic spindle orientation in Saccharomyces cerevisiae. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the orientation of the mitotic spindle along the planar or apical-basal axis (Pease and Tirnauer ...2011). Spindle orientation is also dependent on the evolutionary conserved Par-proteins and ...
108
The ε-Subunit of Mitochondrial ATP Synthase Is Required for Normal Spindle Orientation During the Drosophila Embryonic Divisions
... In vivo fluorescence analysis: For anti-␣-tubulin and propid- (ε)-subunit of the mitochondrial ATP synthase. Embyros ium iodide staining, embryos were fixed in formaldehyde, lacking maternal sun display defects in actin ...
12
The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis
... We hypothesized that loss of planar OCD could be a consequence of defective planar cell polarity (PCP) signaling in the absence of Arl3. PCP signals in Drosophila and zebrafish can direct planar mitotic spindle ...
13
PAR 1 promotes primary neurogenesis and asymmetric cell divisions via control of spindle orientation
... In both the invertebrate and vertebrate embryonic central nervous system (CNS), deep cells differentiate while more superficial (ventricular) epithelial cells remain in a proliferative, stem cell state (Götz and Huttner, ...
5
Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia
... mitotic spindle orientation are ...division orientation within the epithelial plane and inhibit asymmetric division ...mitotic orientation within epithelia by binding F-actin and the protein ...
10
Dynamic localization of the C. elegans GoLoco proteins GPR-1_2 mediates mitotic spindle orientation in response to extrinsic signals
... Drosophila neuroblasts, which are central nervous system progenitor cells, form by delamination from the neuroepithelium during embryonic development. Once delaminated, neuroblasts become polarized and undergo repeated ...
118
Molecular pathways regulating mitotic spindle orientation in animal cells
... mitotic spindle to influence its position prior to cell division ...as spindle-capture ...the spindle. The cortex, by contrast, contains orientation cues, such as Pins and Dsh, that organize ...
14
Spindle orientation: a question of complex positioning
... of spindle orientation in the central nervous system has been associated with hyperplasia in both the fly and chick (de Belle and Heisenberg, 1996; Morin et ...
9
Plk2 regulates mitotic spindle orientation and mammary gland development
... the orientation of the mitotic ...regulates spindle orientation due to the inability to stain centrioles in mammary gland ...proper orientation of the mitotic spindle in non-transformed ...
10
ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
... regulating spindle orientation [25, 39], we asked whether CITK may also play a role in controlling spindle orientation, besides promoting abscission ...mitotic spindle perpendicular to ...
47
Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.
... block the PI-specific spindle rotation, resulting i n trans- verse orientation of second cleavage spindles in both blastomeres, whereas strong loss-of-function mutations i[r] ...
11
The centrosome orientation checkpoint is germline stem cell specific and operates prior to the spindle assembly checkpoint in Drosophila testis
... centrosome orientation and arrests cells in G2 phase when centrosomes are not correctly ...that spindle orientation in these cells is not under the control of the ...
8
suppresses morphological evolution of the cribriform cancerous phenotype
... in spindle orientation, lumen formation and 3D epithelial morphology [7, 9, ...for spindle alignment [14]. Here we show that PTEN-deficiency induces spindle misorientation (Figure 1A, 1B), ...
23