Src protein tyrosine kinase
Phospholipase Cγ2 is necessary for separation of blood and lymphatic vasculature in mice
... Previous studies have shown that mice lacking either the spleen tyrosine kinase Syk or Src-homology 2 SH2 domain-containing leukocyte protein of 76 kDa SLP76 exhibited blood-lymph shunts[r] ...
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Genome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells
... either Src or FAK is inhibited, the phosphorylation of Src and FAK is disrupted, thereby disrupting the Src-FAK positive-feedback ...that Src inhibition induced death only in heavily infected ...
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Epithelial Cell Adhesion to Extracellular Matrix Proteins Induces Tyrosine Phosphorylation of the Epstein-Barr Virus Latent Membrane Protein 2: a Role for C-Terminal Src Kinase
... with Src kinases in B cells (20), was not phosphorylated in epithelial ...established tyrosine Y112 as important for LMP2A phosphorylation ...surrounding tyrosine Y112 in epithelial ...Interestingly, ...
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Elevated c Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis
... membrane-associated protein tyrosine kinases. For the viral protein or transforming mutants of the cellular protein (Src), a close correlation exists between elevated tyrosine ...
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Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein
... by Src, we repeated the co- expression of APP and Mint in COS7 cells in the presence or absence of the Src family kinase inhibitor PP2 (Hanke et ...suggesting Src inhibition had partially ...
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Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation.
... Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp6Osrc inactivate tyrosine protein kinase activity.. Myristic acid is attached to the [r] ...
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Transforming properties and substrate specificities of the protein tyrosine kinase oncogenes ros and src and their recombinants.
... We next examined cellular proteins phosphorylated by the tyrosine kinases of UR2, RSV, and their recombinants as well as a number of other avian sarcoma viruses including Fujinami sarcom[r] ...
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Intracellular localization and processing of pp60v-src proteins expressed by two distinct temperature-sensitive mutants of Rous sarcoma virus.
... 876 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The transforming protein of Rous sarcoma virus, pp6Ov-src, is known to be a tyrosine protein kinase, but the mechani[r] ...
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IN SILICO INHIBITION OF PROTO ONCOGENE TYROSINE PROTEIN KINASE SRC (C SRC) BY ARISTOLACTAM A II, 4 ALLYL RESORCINOL AND STIGMAST 4 EN 3, 6 DIONE FOR ANTICANCER ACTIVITY OF PIPER BETLE LINN (PIPERACEAE): TRADITIONAL CLAIM REVALIDATED
... proto-oncogene tyrosine protein kinase Src (c-Src) and Cyclin dependent kinase 2 (CDK2) was selected based on their report of anticancer activity and listing in target prediction ...
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Suppression of v-src Transformation by the drs Gene
... v-Src protein was inhibited in the clones expressing exogenous drs gene, the tyrosine kinase activity of v-Src protein in MRSV-infected cells was examined by in vitro ...
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Acid sensing in renal epithelial cells
... proline-rich tyrosine kinase 2 (Pyk2), a member of the focal adhesion kinase (FAK) family, acts as both a pH sensor and activator of ...cytoplasmic protein tyro- sine kinase, is ...
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Synthesis and Evaluation of Ethyl 2,4-dioxo-4-arylbutanoate Derivatives as Src Kinase Inhibitors
... of Src kinase was determined using HTScan Src Kinase Assay Kit, catalogue number 7776 from Cell Signaling Technology (Danvers, MA, USA); according to manufacturer's ...the kinase ...
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Role of phosphatidylinositol 3-kinase as an effector of Ras
... The biological significance of membrane ruffling is not clear but its occurrence generally correlates with cell motility and in particular with directed migration or chemotaxis (Ridley, 1994). Interestingly both Ras and ...
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Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family.
... p65 kinase, labeled by autophosphorylation in a complex with the modified Nef, was released into solution by elution with the FLAG ...anti-rat protein an- tisera with the human kinase, since partial ...
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pp60c-src binding to polyomavirus middle T-antigen (MT) requires residues 185 to 210 of the MT sequence.
... gest that PP2A influences the final location of the MT complex rather than MT controlling the distribution of its associated proteins, as is usually envisaged. However, we cannot yet for- mally exclude a more indirect ...
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The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
... The role of SOCS3 in the development and function of Treg cells is still undetermined [69]. SOCS3 may sup- press Treg proliferation. It also suppresses CTLA4 and FoxP3 levels by repressing IL-2 expression [70]. SOCS3 ...
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Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice
... the Src kinase is implicated in the development of a variety of human ma- ...monitor Src activity in an in vivo setting with current biochemical ...of Src kinase both in vitro and in ...
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PTP1B: a new therapeutic target for Rett syndrome
... which tyrosine residues were mutated to phenylalanine to determine the exact tyrosine residue(s) targeted by ...enhanced tyrosine phosphory- lation of Y706/Y707 in the brains of Mecp2 –/+ ...
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SHP2 mutations induce precocious gliogenesis of Noonan syndrome-derived iPSCs during neural development in vitro
... Next, we questioned whether neuronal cells differenti- ated from NS-NPCs were normal or abnormal. Intri- guingly, the NS-neural cells had shorter dendritic and axonal lengths than the WT-neural cells (Fig. 3c). It is ...
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Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.
... 70-kDa protein. We have identified this protein by immunoblotting as the constitutive 73K heat shock protein (data not ...shock protein associates with another PP2A-defective MT mutant, NG59, ...
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