Summary molecular function gene ontology analysis
Towards refactoring the Molecular Function Ontology with a UML profile for function modeling
... Further analysis of MFO terms on the basis of FueL constituents such as operands and modes leads to the identification of functions that are specialized (1) almost exclusively by mode additions or mode ...
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The classification of gene products in the molecular biology domain: Realism, objectivity, and the limitations of the Gene Ontology
... The Gene Ontology’s dependency on electronically inferred annotations based on sequence analysis mirrors Rudwick’s problem of accommodating a teleological perspective when interpreting the fossil ...the ...
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Annotation of gene product function from high-throughput studies using the Gene Ontology.
... specialized molecular interactions resources. Indeed, binary molecular interactions are more comprehensively covered by dedicated curation flows, and curation of high-throughput physical interactions using ...
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Ontological realism, concepts and classification in molecular biology: Development and application of the gene ontology
... interpretations, analysis and results of linguistic features, syntax, speech acts and implicature relevant to understanding the role played by power and authority in the resolution of disputes between ...in ...
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Primer on the Gene Ontology.
... the ontology, but their status changes to obsolete and all relationships to the term are removed [ 6 ...of gene products and a biological process rather than a molecular ...
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Gene Ontology Function prediction in Mollicutes using Protein-Protein Association Networks
... We have performed this study on seven Mycoplasma species proteomes. One of the main limitations in using protein-protein interactions for function prediction is the availability of interaction data, especially if ...
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Logical Gene Ontology Annotations (GOAL): exploring gene ontology annotations with OWL
... the Gene Ontology (GO) and their use in annotations make cross species comparisons of genes possible, along with a wide range of other analytical ...of gene products that can be exploited in query ...
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Globaltest and GOEAST: two different approaches for Gene Ontology analysis
... With Globaltest, enriched GO terms can be found because only a few genes are highly differentially expressed or because many genes are only slightly differentially expressed. This may help to distinguish the key player ...
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Gene ontology analysis for RNA seq: accounting for selection bias
... GO analysis for microarray data, the null proba- bility distribution does not conform to a standard distri- bution, precluding an analytical solution for determining the probability of a category being ...
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Comparative GO: a web application for comparative gene ontology and gene ontology-based gene selection in bacteria
... proteins using a controlled vocabulary in terms of their Molecular Function, Biological Process and Cellular Component. The challenge is to present this information to researchers to compare and discover ...
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Cloning and molecular characterization of a metabolic gene with development functions in Drosophila. I. Analysis of the head function of Punch.
... Pu mutants with phenotypes that are restricted to specific developmental times or tissues, as well as mutants that are defective in all known Pu functions. These resu[r] ...
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The Gene Ontology: enhancements for 2011
... a gene as- sociation file or ...the gene product being annotated, evidence supporting the annotation, the group making the annotation and the GO term associated with the an- ...a gene product and ...
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Gene Ontology Analysis of 3D Microarray Gene Expression Data using Hybrid PSO Optimization
... 4. Gene Ontology Annotation The experimental study is conducted to CDC15 dataset is a microarray gene expression data with this link ...process, molecular function and the cellular ...
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Measuring the evolution of ontology complexity: the gene ontology case study
... and analysis of life sciences ...an ontology evolution on its structural ...the Gene Ontology and its three independent branches, ...and molecular functions ...an ontology does ...
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Contextual analysis of variation and quality in human-curated gene ontology annotations
... 2.3. Participant selection and group assignment 2.3.1. General Model organism database curators are typically current or former scientists with Ph.D-level training in molecular biology, biochemistry, or in a ...
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Molecular Function Analysis of Rabies Virus RNA Polymerase L Protein by Using an L Gene-Deficient Virus
... L gene-deficient, reporter gene-expressing virus in all species of the or- der Mononegavirales, also highlighting its applicability to a trans-complementation assay, which is useful for molecular ...
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A piggyBac Transposon Gene Trap for the Analysis of Gene Expression and Function in Drosophila
... site gene trap vector (PBss) was accomplished by heat-shock-induced expression of piggyBac transposase ...trapped gene. As homozygotes, these fusions can inactivate the gene and lead to ...lethality. ...
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Gene Ontology consistent protein function prediction: the FALCON algorithm applied to six eukaryotic genomes
... protein function predic- tion methods is to provide reliable and interpretable results, in order to be useful for the biological commu- ...the Gene Ontology (GO) controlled vocabulary [1] to describe ...
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Gene Ontology consistent protein function prediction: the FALCON algorithm applied to six eukaryotic genomes
... propagate function information through networks of protein associations and this operation is performed per GO ...overrepresentation analysis for each GO term ...
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Quantifying Protein Function Specificity in the Gene Ontology
... The most unique aspect of IC is that it is calculated from data. The strength of IC, however, doubles as a caveat: since it is data dependent, the IC of a par- ticular GO term may fluctuate from data set to da- ta set. ...
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