Switched memory B cells
Increased levels of (class switched) memory B cells in peripheral blood of current smokers
... more memory B cells including class- switched memory B cells than ex- and never ...class-switched memory B cells are mature B ...
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Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype switched, memory B cells in X linked lymphoproliferative disease
... many B cell lymphomas resemble GC B cells (71), it is tempting to speculate that the reason why B cell lymphomas in XLP are predominantly extranodal and restricted to the gut is because the ...
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journal.pone.0108663.PDF
... normal B cell ontogeny in BM; and (iii) poor antigen-specific IgG response to ...human B and T cells are interacting in vivo in a tractable small animal model; (ii) HLA- restricted T-cells are ...
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Immunosenescence in B Cells: A Study on Changes in Immunoregulator Expression and Metabolism With Age
... in B cells and antibody secreting cells (ASCs) in mice and ...of B and T Lymphocyte attenuator (BTLA) on their ...mature B cells was linked to higher IgG responses to the H1N1 ...
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The B-cell compartment in antibody-deficient infants and young children – developing common variable immunodeficiency or transient immune maturation?
... the B-cell subpopula- tions with the use of age-specific cut-off reference values is of critical importance, but none of the above mentioned classification schemes clearly defines such age-matched ...the ...
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The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age
... IgG+ switched memory B cells, which are all antigen-experienced cells though arising via distinct acti- vation ...the memory B cell populations are so small that they can ...
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Class switched B cells display response to therapeutic B cell depletion in rheumatoid arthritis
... class-switched memory B cells ...plasma cells may also derive from extrafollicular mat- uration ...plasma cells are primarily resistant to RTX due to a lack of CD20 expression, ...
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Mature B cells class switched to IgD are autoreactive in healthy individuals
... and memory cells (Figure 1C). Concurrently, Cδ-CS B cells are also the most often autoreactive, though unlike IgG and IgM memory cells, the 10% of Cδ-CS B cells ...
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Molecular single cell analysis reveals that CD5 positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation
... tonsillar B cell subsets with regard to CD5 ex- ...on B cell subsets derived from secondary lymphoid organs resem- bles that seen in the PB, we analyzed tonsillar B cells for ex- pression of ...
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Keener_unc_0153D_14925.pdf
... of memory B ...antigen-specific memory B cells after in vitro polyclonal stimulation as no flow cytometry methods are ...IgG-secreting cells detected by ELISpot were derived from ...
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Persistence of Epstein-Barr Virus in Self-Reactive Memory B Cells
... ory B cell compartment. This niche consists of GC-derived, iso- type-switched memory cells that preferentially lack polyreactivity but nevertheless include a small proportion of cells ...
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Human immunoglobulin selection associated with class switch and possible tolerogenic origins for Cδ class switched B cells
... these cells and con- tributes to class-related selection, as naturally occurring or muta- tionally generated autospecific B cells may become tolerized so that class switch is ...autoreactive B ...
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Human CD4 CD8 Invariant Natural Killer T Cells Promote IgG Secretion from B Cells Stimulated by Cross Linking of Their Antigen Receptors
... by B cells was more dramatically accelerated by DN iNKT cells than by CD4 iNKT ...iNKT cells have the potential to produce large amounts of Th2 cytokines such as IL-4 and IL-13, DN iNKT ...
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Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation
... centrifuge. Cells were seeded in a 96-well round-bottom plate at a concentration of 5 × 10 5 cells/ ...well. Cells were incubated on ice with 5 μg/mL purified stimulatory mouse anti-human CD40 ...
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Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor
... suspensions. Cells were stained with anti-CD19 PECy5 (Beckman Coulter, Fullerton, CA, USA), anti-CD27 FITC, anti-IgM PE and anti-IgD PE (all from Becton Dickinson, Fullerton, CA, USA), anti-CXCR1 PE, anti- CXCR2 ...
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Immunization With Recombinant Myelin Oligodendrocyte Glycoprotein Identifies Autoreactive T Cells As A Limiting Factor In Autoreactive Germinal Center Maintenance
... autoimmunity. B and T cells collaborate in the GC to target the same antigen (Ag) to inform B cell differentiation; however, the properties of Ags differ substantially in autoimmunity and foreign-Ag ...
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Circulating plasmablasts/plasma cells: a potential biomarker for IgG4 related disease
... Statistical analyses were performed using IBM SPSS Statistics version 19.0 software (IBM, Armonk, NY, USA) and Prism software version 5.0 (GraphPad Soft- ware, La Jolla, CA, USA). A P value <0.05 was consid- ered ...
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Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus
... of B cell tolerance is central to the pathogenesis of systemic lupus erythematosus ...how B cell tolerance is subverted in human SLE is poorly understood due to difficulties in identifying relevant ...
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Progression From IgD+ IgM+ to Isotype-Switched B Cells Is Site Specific during Coronavirus-Induced Encephalomyelitis
... (BAFF-R), B cell maturation antigen (BCMA), and trans- membrane activator and calcium modulator and cyclophilin ligand inter- actor (TACI) were previously described (3, ...
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Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response
... mononuclear cells and flow cytometry PB mononuclear cells and BM mononuclear cells were iso- lated by Ficoll-Histopaque (Sigma-Aldrich, St Louis, MO, USA) density-gradient centrifugation of ...
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