T Cell
T cell homeostasis and systemic autoimmunity
... in T cell maturation may lead to a lymphocyte deficit in the periphery, and consequently, to the initiation of a home- ostatic, yet deleterious, anti-self ...
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Analysis of the human T-cell response to picornaviruses: identification of T-cell epitopes close to B-cell epitopes in poliovirus.
... Twenty-nine individuals responded to poliovirus type 3, coxsackievirus B3, and encephalomyocarditis virus by proliferation of T cells, and from such cultures, 130 virus-specific T-cell l[r] ...
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T cell receptor-engineered T cells for leukemia immunotherapy
... human T cells to endow their specificity toward leukemia cells is becoming an interesting tool for T cell immunotherapy for hemato- logical ...of T cell subpopulations for gene trans- ...
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Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance
... ⫹ T cell populations, after initiation of ...and cell surface phenotype after initia- tion of ART could provide a context for epitope-specific immune ...epitope-specific T cells at post-ART ...
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Specific T cell activation in an unspecific T cell repertoire
... blood cell that circulate around our bodies, scan- ning for cellular abnormalities and ...the T-cell antigen receptor ...the T-cells it needs. This is clearly absurd and suggests that ...
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T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia
... mature T-ALLs (8/14) that usually displayed T3. The 3A-1 T cell associated antigen appeared earliest in development followed by T11 and ...pre-B cell ALL a higher incidence of lineage ...
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Original Article Detection of immunoglobulin and T-cell receptor gene rearrangements in angioimmunoblastic T-cell lymphoma
... peripheral T-cell lympho- ma of the lymph node that accounts for 1-2% of non-Hodgkin’s lymphomas and approximately 15% of peripheral T-cell lymphomas ...
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Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis
... antigen-specific T cells by providing them with the first boost of apoptotic ...gen-specific T cell responses would represent an epiphe- nomenon of the responses that have initiated the inflammatory ...
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The Effect of T Cell Receptor Specificity on CD4+CD25+ Regulatory T Cell Function in an Autoimmune Setting
... + T cells that have been injected systemically can be found in the draining lymph node, synovial fluid, and synovial tissue as early as one day post transfer, indicating that the cells are trafficking to the ...
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Critical roles of Bim in T cell activation and T cell–mediated autoimmune inflammation in mice
... B cell lymphoma 2–interacting (Bcl2-interacting) mediator, maintains immunological tolerance by deleting autoreactive lymphocytes through ...Bim-deficient T cells had diminished cytokine production. Upon ...
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T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
... naive T cell responses to invading pathogens, inducing clonal expansion, cytokine production, and the acquisition of effector functions (2, 3, ...the T cell response (12–16). Productive ...
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MHC ligand generation in T cell-mediated immunity and MHC multimer technologies for T cell detection
... DCs to acquire antigen while minimizing the complete de- struction of peptide determinants and therefore be benefi- cial to ensure T cell activation upon arrival in the lymph node (11). In contrast, ...
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Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice
... was not reflected in any obvious (Fig. 2; Table 1) defect in the level of CTL effector function (in the BAL specimens) or in the capacity to produce IFN-␥ following short-term, in vitro stim- ulation with peptide (in the ...
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CD8<sup>+</sup> memory T-cell inflation renders compromised CD4<sup>+</sup> T-cell-dependent CD8<sup>+</sup> T-cell immunity via naïve T-cell anergy
... after T-cell transfer. (B) 90 days after T-cell transfer, blood samples from Ova-mT B6 mice were stained with PE-Ova tetramer, FITC-CD8 Ab, and PE-Cy5-Abs specific for CD44, CD62L, or IL7R, ...
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Superior T memory stem cell persistence supports long lived T cell memory
... identified T cells with a T SCM phenotype and stem cell–like properties in nonhuman ...Antigen-specific T SCM cells preferentially localized to LNs and were virtually absent from mucosal ...
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Allogeneic Differences in the Dependence on CD4+ T-Cell Help for Virus-Specific CD8+ T-Cell Differentiation
... ⫹ T-cell-deficient C3H mice, we observed a dissoci- ation between cytokine and cytotoxic activities by PyV-specific effector CD8 ⫹ T ...⫹ T cells produced IFN- ␥ and degranulated upon cognate ...
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T cell repertoire remodeling following post transplant T cell therapy coincides with clinical response
... near-monoclonal T cell population domi- nated by a single TRBV ...patients, T cell receptor diversity is known to play an important role in viral control (34, ...stem cell transplant ...
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CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation
... +ICR-modified T cells were added to tumor cells to achieve a T cell:tumor cell ratio of 1:10 in the presence of 400 U/mL ...beads. T cells were then purified using CD3 microbead column (MACS) ...
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T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
... ⫹ T-cells Exhibit Substantial Diversity in Their Ability to Recognize Natural Tumor Epitopes—It is established that the ELAGIGILTV and EAAGIGILTV peptides exhibit differential binding to HLA A*0201 (34, ...higher ...
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Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1
... ⴙ T-cell responses within indi- ...⫹ T-cell responses in three individuals ...⫹ T-cell responses evolve independently of the host, most likely driven by TCR-antigen ...
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