T-Cell Receptor Beta Chain
Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins.
... Both ets and cbf binding sites are required for ets proteins to transactivate the TCR b enhancer in Drosophila S3 cells. Be- cause the ets proteins did not transactivate either the Mo-MLV or TCR b enhancer in mouse P19 ...
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Virus-specific CD8+ T-cell responses in mice transgenic for a T-cell receptor beta chain selected at random.
... Depletion of the CD4+ T-cell subset had little effect on the course of influenza virus infection but substantially slowed the development of the Sendai virus-specific CTL response and vi[r] ...
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T cell receptor beta chain gene rearrangement shared by murine T cell lines derived from a site of autoimmune inflammation
... the T lymphocyte antigen-receptor have now made it feasible to study human autoimmune diseases using new ...of T cells from sites of autoimmune pathology followed by identification of putative ...
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Bias toward use of a specific T cell receptor beta chain variable region in a subgroup of individuals with sarcoidosis
... of T cell antigen receptor beta variable (V) regions may be manifested in T lymphocytes that accumulate in nonmalignant, T cell- mediated human disorders, a V beta ...
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Peters, Philipp (2018): T cell receptor modification by alpha and beta chain domain cross-over for adoptive T cell therapy. Dissertation, LMU München: Medizinische Fakultät
... However, if domain crossing affects the overall tertiary structure of one chain, one would expect an impact on the tertiary structure of the second chain. Yet, our results suggest that the structure of this ...
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T cell receptor alpha chain gene rearrangements in B precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia Comparative study of T cell receptor gene rearrangement in childhood leukemia
... and beta-chain genes, whereas the remaining six had no rearrangements of gamma- and beta-chain ...alpha- chain gene rearrangement is not specific for T lineage cells and gamma- ...
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Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq
... TCR beta chains expressed by T-cells and as a proof of concept applied it to a set of 71 single-cell mouse T-cell RNAseq ...in T-cells ...and beta variable gene usage ...
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Interaction of HLA DRB1*1501 and TNF Alpha in a Population based Case control Study of Multiple Sclerosis
... (HLA), T cell receptor beta (TCA receptor β), tumor necrosis factor α (TNF α), tumor necrosis factor β (TNF β), apolipoprotein E (APOE), interleukin 7 receptor alpha chain ...
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Immunization with T cell receptor V beta chain peptides deletes pathogenic T cells and prevents the induction of collagen induced arthritis in mice
... 10–expressing T cells were ...anti–T cell re- ceptor proliferative responses can be demonstrated in rats im- munized with TCR peptides and that only certain regions of the TCR peptides are ...
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Structure and specificity of T cell receptors expressed by potentially pathogenic anti DNA autoantibody inducing T cells in human lupus
... autoimmune T helper (Th) cells. Herein, we sequenced the T cell receptor (TCR) alpha and beta chain genes expressed by 42 autoimmune Th lines from lupus patients that were mostly ...
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Molecular characterization of T cell receptor beta variable in the peripheral blood T cell repertoire in subjects with active tuberculosis or latent tuberculosis infection
... + T cells The GoTaq® qPCR Master Mix (with Rox™ dye) (Promega, Madison, WI, USA) was used as the real-time PCR ...TCR beta chain constant 1 (TCRBC1) and glyceraldehyde-3-phosphate dehydrogen- ase ...
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T cell receptor V beta gene bias in rheumatoid arthritis
... Polymerase chain reaction (PCR) technology was employed to examine peripheral blood and synovial T cells in patients with rheumatoid arthritis (RA) for biased utilization of T cell ...
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Simplified Fluorescent Multiplex PCR Method for Evaluation of the T-Cell Receptor Vβ-Chain Repertoire
... the T-cell receptors (TCR) ...and beta chain (6). Each chain is the product of a complex gene recom- bination rearrangement process that takes place during the intrathymic ...
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Rearrangement of the beta chain of the T cell antigen receptor and immunoglobulin genes in lymphoproliferative disorders
... lymphoepitheloid cell (Lennert's) lymphomas; four of eight Hodgkin's lymphomas; seven of ten Ki 1+ lymphomas; and all nine cases of angioimmunoblastic lymphoadenopathy ...lymphoepitheloid cell lymphomas; ...
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Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages
... Complete embryos before 14.5 dpc and hearts from older time points were fixed by immersion overnight in saline phosphate buffer containing 4% paraformaldehyde and paraffin embedded. Tissue sections 3 μm thick, were ...
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T cell receptor signaling for γδT cell development
... The TCR is a complex receptor that consists of receptor subunits (TCRαβ or γδ) and CD3 subunits (CD3γ, δ, ε, and ζ) [16]. TCR signal transduction involves the conform- ational change, as well as the ...
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Viral Modulation of T-Cell Receptor Signaling
... Since T cells represent the main site of HIV replication in vivo, per- haps it should not be surprising that HIV is a talented manip- ulator of T-cell ...to T-cell biology, it should ...
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T cell receptor (TCR) transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFβ) signaling mediate superior tumor regression in an animal model of adoptive cell therapy
... melanoma cell line (American Type Culture Collection) was maintained in DMEM (Mediatech) with 10% FCS (Omega Scientific) and 1% (v/v) penicillin, streptomycin, and amphotericin (Omega ...
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Sampling from T cell receptor repertoires
... Abstract Modern single-cell sequencing techniques allow the unique TCR sig- nature of each of a sample of hundreds of T cells to be read. The mathematical challenge is to extrapolate from the properties of ...
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Presence of Oligoclonal T Cells in Cerebrospinal Fluid of a Child with Multiphasic Disseminated Encephalomyelitis following Hepatitis A Virus Infection
... The NPA-PCR–V-specific PCR–mixed ligation–mixed transformation– mixed cloning method that we employed here has been designed to determine whether there are clonal expansions of T cells in the CSF rather than to ...
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