T-cell transcription factor 4
The transcription factor IFN regulatory factor–4 controls experimental colitis in mice via T cell–derived IL 6
... regulatory factor–4 (IRF4) in this ...+ T cells as compared with control ...in T cells, in a mouse model of IBD whereby colitis is induced in RAG-deficient mice by transplantation with CD4 + ...
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HYPOXIA INDUCIBLE FACTOR AND OSMOREGULATORY MOLECULES AFFECT CELL BLEBBING; IMPLICATIONS FOR SENESCENCE AND AGEING PROCESS
... by cell shrinkage in a hypertonic ...gene transcription is carried out by multiple enhancers known as the osmotic-reponse element (ORE) or tonicity- response enhancer (TonE) that are located in the ...
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Muscle Cell Fate Choice Requires the T-Box Transcription Factor Midline in Drosophila
... H15 T-box factor in development of the lateral oblique 1 (LO1) muscle and the segment border muscle ...Tbx transcription factor Mid as a novel iTF for the specification of the LT3/4 ...
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Characterization Of Human T-Bet-Expressing B Lymphocytes And Their Role In The Hiv Immune Response
... B cell lineage and function to constitutively produce and secrete antibodies ...by T-dependent germinal center reactions (27, ...B cell identity, which is achieved by transcriptional repression of ...
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Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3′ Long Terminal Repeat
... bp. Cell debris were pelleted by centrifugation (20,000 ⫻ g, 4°C), and supernatants were ...(C T ) value was determined from triplicate reactions and normalized against nonspecific IgG controls with ...
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PubMedCentral-PMC5298956.pdf
... IL-17-producing T cells ...or transcription factor that prevents Th17 generation (106, ...from T cells (Figure ...favoring T reg differentiation, ...
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Nuclear Wiskott–Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells
... and cell suspension prepared with the use of 100-μm strainers ...For cell frac- tionation, the Nuclear/Cytosol Fractionation Kit #K266-25 (BioVision) was ...min, 4 ° C). Total cell lysates ...
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The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription
... bZIP transcription factors, CREB-2 homodimerization, prob- ably guided by Tax (1, 18, 36), seems to be necessary to activate the viral ...HTLV-1 transcription. However, CREB-2 is not the only bZIP ...
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Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
... represses transcription driven from the HTLV-1 promoter and, more specifically, represses tran- scription mediated through the viral CREs ...CEM T cells that were subsequently treated with forskolin (20 M ...
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Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients
... the T-ALL GMALL patient cohort by quantitative ...a transcription factor up-regulated in DN1 phase of normal T-cell development [39] was sig- nificantly lower expressed in BCL11b-low ...
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Common gamma chain (γc) cytokines differentially potentiate TNFR family signaling in antigen-activated CD8+ T cells
... T cell subsets that mirror those for Th1 and Th2 CD4 + T cells, respectively ...+ T cells are generally capable of secreting abundant IFN-γ in re- sponse to TCR activation, whereas Tc2 cells ...
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Identification of Novel T Cell Factor 4 (TCF-4) Binding Sites on the HIV Long Terminal Repeat Which Associate with TCF-4, β-Catenin, and SMAR1 To Repress HIV Transcription
... a 4-fold increase in HIV replication by inhibiting  -catenin/TCF-4 signaling through in- duction of an antagonist of the -catenin pathway (DKK1) in a Stat3-dependent manner (2, 3, ...HIV ...
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Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
... a transcription factor that is “ monoallelically ” inactivated in ~10 % of human T cell acute lymphoblastic leukemia (T-ALL) [1–3] and several murine T-ALL models, including ATM ...
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In silico design of context-responsive mammalian promoters with user-defined functionality
... of transcription factor regulatory element (TFRE)- combinations were constructed and tested in silico using our model of heterotypic element activities (see Figure ...
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ER stress regulates alkaline phosphatase gene expression in vascular smooth muscle cells via an ATF4 dependent mechanism
... Matinspector (Genomatix) for the presence of transcrip- tion factor binding sites. ALP promoter constructs [14] and pRL-TK renilla luciferase vector (Promega) were transfected into VSMCs using Lipofectamine LTX. ...
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Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta.
... resting T cells, these NF- k B/Rel complexes are sequestered in the cytoplasm as latent precursors by physical association with a family of ankyrin motif-rich inhibitory proteins (6) including I k B a (2, 19), I k ...
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Metastatic biomarkers in synovial sarcoma
... promote cell migration, invasion and angiogenesis [52, ...Nuclear factor-κB (NF-κB), which increases the adhesion and invasive ability of can- cer cells in part by the activity of MMP2 and MMP9 ...stem ...
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Human induced pluripotent stem cell differentiation and direct transdifferentiation into corneal epithelial-like cells
... stem cell deficiency, or in cases of damages from external sources the pool of LESCs is depleted, which leads to an impairment in corneal epithelial maintenance and consequent ...stem cell transplantation ...
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MANGIFERA INDICA L. EXTRACT MODULATES NF-KAPPAB SIGNALING PATHWAY IN THE COURSE OF ACTIVATION-INDUCED T CELL DEATH
... Activation-induced cell death (AICD) plays an important role in maintenance of peripheral lymphocyte ...several transcription factors that cooperatively act on the CD95L promoter to induce de novo ...
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Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.
... Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor KB and induces nuclear translocation of transcription factor NF-KB proteins for transcr[r] ...
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