Tanshinone IIA
Tanshinone IIA Protects Against Cardiac Hypertrophy via Inhibiting Calcineurin/Nfatc3 Pathway
... worldwide. Tanshinone IIA is a lipid-soluble pharmacologically active compound extracted from the rhizome of the Chinese herb Salvia miltiorrhiza, a well-known traditional Chinese medicine used for the ...
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Original Article Tanshinone IIA pretreatment attenuates oxygen-glucose deprivation induced hippocampal neurons damage
... Objective: Tanshinone IIA (Tan IIA) has been used in treatment of ischemic stroke in ...Tan IIA pretreatment in primary cultured rat hippocampal neurons incurred oxygen-glucose deprivation ...
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Original Article Tanshinone IIA protects against polyethylene particle-induced osteolysis response in a mouse calvarial model
... of tanshinone IIA on wear granules that lead to bone absorption may be associated with chang- es in the balance between OPG and ...with tanshinone IIA for 21 days. It is shown that the ...
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Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor
... Abstract: Tanshinone IIA (Tan IIA) (C 19 H 18 O 3 ) is one of the major active lipophilic components in a conventional Chinese medicine called danshen, and it has long been used in the People’s ...
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Original Article Sensitization to tamoxifen by tanshinone IIA in tamoxifen-resistant breast cancer cells in vitro
... Cell counting kit-8 (CCK-8; Boppard, Shanghai, China) was used to measure the cell prolifera- tion. MCF-7 or MCF-7-TamR cells were seeded in full growth medium, which was replaced with RPMI-1640 24 h later, and the cells ...
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Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1
... Abstract: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein possessing both DNA repair and redox regulatory activities. It has been shown that block- ing redox function leads ...
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Tanshinone IIA promotes the differentiation of bone marrow mesenchymal stem cells into neuronal like cells in a spinal cord injury model
... Spinal cord injury (SCI) is one of the most severe cen- tral nervous system (CNS) lesions that affects a patient’s physical and mental health, has a heavy economic burden on society and detrimentally affects the ...
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Original Article Effects of Tanshinone IIA sodium sulfonate on LPS-induced acute lung injury in mice
... ALI, one complication of sepsis, is still a major and increasing cause of mortality and morbidi- ty throughout the world [30, 31]. Researchers are trying to explore the reliable therapy to over- come this worldwide ...
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Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization
... metastases. Tanshinone IIA did not inhibit growth of single-xenotransplanted tumors, but it did reduce the occurrence of ...survival. Tanshinone IIA alleviated residual tumor hypoxia and ...
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Tanshinone IIA attenuates demyelination and promotes remyelination in A. cantonensis-infected BALB/c mice
... dexamethasone, Tanshinone IIA (TSIIA) and Cryptotanshinone(Two traditional Chinese medicine monomers) in combination with albendazole (AB, a standard anti-helminthic compound) to observe their therapeutic ...
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<p>Tanshinone IIA Reverses Gefitinib-Resistance In Human Non-Small-Cell Lung Cancer Via Regulation Of VEGFR/Akt Pathway</p>
... Tanshinone IIA (Tan IIA) is a lipophilic components deriv- ing from the roots of Chinese herbs medicine Salvia miltior- rhiza ...Tan IIA has been found to possess a number of biological ...
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Tanshinone IIA attenuates Aβ-induced neurotoxicity by down-regulating COX-2 expression and PGE2 synthesis via inactivation of NF-κB pathway in SH-SY5Y cells
... [9]. Tanshinone IIA (Tan IIA) is one of major lipophilic component extracted from a well-known tra- ditional herb Radix salvia miltiorrhiza (Danshen) ...Tan IIA has been reported to suppress ...
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<p>The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation</p>
... covery. Tanshinone IIA (Tan IIA) is the most important active component of the traditional Chinese herb Salvia miltiorrhiza (Danshen), which possesses superior bio- availability and various ...
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Tanshinone IIA Could Inhibit Pancreatic Cancer BxPC 3 Cells through Increasing PERK, ATF6, Caspase 12 and CHOP Expression to Induce Apoptosis
... Tanshinone IIA (Tan-IIA) is extracted from Dan-Shen. Tan-IIA could inhibit human pancreatic can- cer BxPC-3 cells through decreasing TCTP, Mcl-1 and Bcl-xl expression in ...
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Original Article Tanshinone IIA reduces oxidized low-density lipoprotein-induced inflammatory responses by downregulating microRNA-33 in THP-1 macrophages
... Abstract: Atherosclerosis is a leading cause of cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL) is commonly used to construct atherosclerosis cell models. Macrophages-secreted pro-inflammatory factors ...
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<p>Tanshinone IIA Ameliorates Progression of CAD Through Regulating Cardiac H9c2 Cells Proliferation and Apoptosis by miR-133a-3p/EGFR Axis</p>
... health. Tanshinone IIA (Tan IIA), which could be extracted from Danshen, is applied in the treatment of cardiovascular and cerebrovascular ...Tan IIA in CAD in vitro and the underlying ...
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Original Article Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production
... properties. Tanshinone IIA (Tan) is a major effective com- pound of Danshen, and has been widely used clinically for the prevention and treatment of cardiovascular ...
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Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy
... Akt/NF-B-dependent pathway [19]. In addition, TSN protects against cardiotoxicity induced by doxorubicin in vitro and in vivo concluded by Jiang and colleagues [20]. Hong [21] et al. reported that tanshinone ...
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Tanshinone IIA pretreatment protects free flaps against hypoxic injury by upregulating stem cell related biomarkers in epithelial skin cells
... Tanshinone IIA (TSA) is the most abundant diterpene quinone isolated from Danshen (Salvia miltiorrhiza) and has been used to treat cardiovascular diseases for more than 2000 years in ...
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Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain
... (SNL). Tanshinone IIA, a major active component of a traditional Chinese drug, Danshen, possesses potent immuno-suppressive ...of tanshinone IIA sulfonate (TIIAS) has analgesic effect on ...
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