targeting efficiency
Deletion of the DNA Ligase IV Gene in Candida glabrata Significantly Increases Gene-Targeting Efficiency
... the efficiency of correct targeting is about 35 times higher in the lig4⌬ strain than in the wild-type strain, when using 40-bp flanking sequences ...gene targeting efficiency was even higher ...
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Synthesis of novel tetravalent galactosylated DTPA-DSPE and study on hepatocyte-targeting efficiency in vitro and in vivo
... This study aimed to develop a Gal-modified liposomal formulation for DOX delivery and evaluate its effect of target- ing to the liver. 4Gal-liposomes were composed of 1,2-dis- tearoyl-sn-glycero-3-phosphocholine (DSPC), ...
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Formulation and targeting efficiency of cisplatin engineered solid lipid nanoparticles
... the targeting efÞ ciency of drug-loaded solid lipid nanoparticles with that of free drug in terms of percentage increase in targeting to various organs of reticuloendothelial system like liver, lungs, ...
5
Rural development NGOs and service delivery to the very poor: An empirical analysis of a training center in rural Cameroon
... geographic targeting of rural areas as most of the poverty indices of the households both for beneficiary and non- beneficiary households are ...improve targeting efficiency of such ...
13
Preclinical evaluation of [68Ga]NOTA-pentixafor for PET imaging of CXCR4 expression in vivo — a comparison to [68Ga]pentixafor
... Ga]NOTA-pentixafor was now evaluated preclinically and compared to [ 68 Ga]pentixafor (Fig. 1), which is currently entering clinical studies for PET-based quantification of CXCR4 expression in vivo [5, 6, 12]. ...
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DESIGN, CHARACTERIZATION AND COMPARATIVE EVALUATION OF FOLATE MEDIATED TARGETING OF THERAPEUTICS
... encapsulation efficiency, controlled release nature and highest targeting efficiency to the inflammatory ...active targeting over dendrimer mediated passive targeting and also for the ...
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Folic acid-CdTe quantum dot conjugates and their applications for cancer cell targeting
... and targeting properties of folic acid-CdTe quantum dot conjugates were studied and the interaction between folic acid and CdTe quantum dots was ...tumor targeting efficiency of the folic acid-CdTe ...
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Genome editing with targetable nucleases makes large animals catch up with mice
... high efficiency of gene targeting in cultured somatic ...the efficiency of around 10% (ranging from 1 to 20% in different studies) ...Such efficiency is several orders of magnitude higher than ...
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Comparison of anti-EGFR-Fab’ conjugated immunoliposomes modified with two different conjugation linkers for siRNA delivery in SMMC-7721 cells
... transfection efficiency and gene ...EGFR targeting efficiency and achieved superior gene silencing activity in ...the targeting LPD is modified by anti-EGFR Fab’ con- jugation with ...
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DEVELOPMENT, EVALUATION AND TARGETING OF IMATINIB MESYLATE LOADED SOLID LIPID NANOPARTICLES TO THE LYMPHATIC SYSTEM
... the targeting potential of solid lipid nanoparticle (SLN) formulation of imatinib mesylate to the lymphatic system using response surface methodology of design of ...entrapment efficiency (Y2) as dependant ...
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In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy
... the targeting ability of the GNPs, which is a function of the particle’s geometric properties (eg, size) and dosing strategy (eg, number and amount of ...tumor targeting. Specifically, we investigated the ...
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Self-Assembly of Gold Nanoparticles Shows Microenvironment-Mediated Dynamic Switching and Enhanced Brain Tumor Targeting
... tumor targeting and ...tumor-targeting efficiency and therapeutic effects relative to single-nanoparticle ...effective targeting strategy for brain tumor ...
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Development of a Highly Efficient Gene Targeting System Induced by Transient Repression of YKU80 Expression in Candida glabrata
... gene targeting to generate knockouts and “knockins” is a poten- tially powerful method for the analysis of gene ...gene targeting was ...in targeting efficiency of ...gene targeting ...
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NANOCARRIER FOR INTRANASAL ADMINISTRATION
... brain targeting efficiency, after nasal dosing, statistical differences between intramuscular conventional solution, intranasal conventional solution and intranasal nanoemulsio were assessed by comparison ...
6
Optimizing a CRISPR-Cpf1-based genome engineering system for Corynebacterium glutamicum
... crRNA targeting efficiency in ...editing efficiency, could be used to increase the production of bulk chemicals, such as isobu‑ tyrate, in ...
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Optimizing sgRNA structure to improve CRISPR Cas9 knockout efficiency
... knockout efficiency, but after reaching a peak at around 5 bp, the effect declines, which might explain this ...imaging efficiency of the dCas9–GFP fusion protein in ...tion efficiency due to the ...
10
Targeting Exemption for Charitable Efficiency: Designing a Nondiversion Constraint
... Targeting Exemption for Charitable Efficiency Designing a Nondiversion Constraint SMU Law Review Volume 56 | Issue 1 Article 24 2003 Targeting Exemption for Charitable Efficiency Designing a Nondivers[.] ...
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LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer
... To evaluate whether CPSF3 has effects similar to those of CASC9 on CRC tumorigenesis, siRNAs tar- geting CPSF3 were utilized to suppress its expression, and knockdown efficiency was assessed by both RT- qPCR and ...
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Development of an MRI-visible nonviral vector for siRNA delivery targeting gastric cancer
... is a promising therapeutic method but is severely hampered due to its lack of an ideal delivery system. One promising approach to overcoming this limitation is the application of targeted-release systems that are ...
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Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery
... internalization efficiency of LMW-CS formulations in different cell ...uptake efficiency, with LMW-CSs 92-10-5 and 80-10-10 more easily internalized compared to the higher molecular weight 80-80-5 and ...
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