Telomerase Reverse Transcriptase
A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis
... that telomerase expression is crucial for the maintenance of telomere homeostasis, there is increasing evidence that the TERT protein can have physiological roles that are independent of this central ...of ...
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Original Article Screening and identification of antisense accessible sites of the human telomerase reverse transcriptase gene in prostate cancer cell lines
... Abstract: Selecting optimal antisense binding sites remains difficult during application of antisense oligonucle- otide techniques. A random oligonucleotide library/RNase H cutting method combined with software analysis ...
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Telomerase reverse transcriptase gene amplification in hematological malignancies
... of telomerase can dramatically increase proliferative life span and promote cellular immortality, thereby contributing to the malignant ...investigate telomerase reverse transcriptase (TERT) ...
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Post-transcriptional regulation of telomerase reverse transcriptase (TERT) in human embryonic stem cells cultured under varying oxygen microenvironments
... of telomerase in regulating stem cell ...for telomerase reverse transcriptase (TERT) expression and telomerase ...the telomerase RNA component (TERC) did ...
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Expression of Telomerase Reverse Transcriptase during the Malignant Transformation of Cadmium Induced Cells
... human telomerase reverse transcriptase (hTERT), the telomerase RNA compo- nent, and human telomerase-associated protein I ...with reverse transcriptase activity that ...
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The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
... man telomerase reverse transcriptase (hTERT) gene ...of telomerase catalytic activity, encodes the reverse transcriptase com- ponent of the telomerase complex, and its ...
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Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding Sites
... induces telomerase activity in human ...activates telomerase. Expression of human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, was found to be ...
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Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase
... Human telomerase reverse transcriptase (hTERT) is the catalytic component of telomerase with reverse transcriptase activity. Stem cells overexpressing hTERT maintained ...
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Telomerase reverse transcriptase methylation predicts lymph node metastasis and prognosis in patients with gastric cancer
... Purpose: Telomerase activity is associated with cellular immortalization and is present in most human tumors but absent in normal ...of telomerase reverse transcriptase (TERT), a catalytic ...
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Association of telomerase reverse transcriptase promoter mutations with clinicopathological features and prognosis of thyroid cancer: a meta-analysis
... of telomerase reverse transcriptase (TERT) promoter mutations have been widely investigated in thyroid cancer; however, the results are still ...
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Human telomerase reverse-transcriptase promoter-controlled and herpes simplex virus thymidine kinase-armed adenoviruses for renal cell carcinoma treatment
... human telomerase reverse transcriptase (hTERT)-controlled herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) in the hTERT promoter-driven HSV-TK/ GCV suicide gene system was ...
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Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas
... 6. Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB, Morin GB: Reconstitution of human ...
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Telomerase reverse transcriptase promoter mutations in a cohort of adult gliomas: Clinicopathological correlates
... This association was found to be statistically significant for progression free p-value 0.002 and overall survival p-value 0.006 TERT promoter mutations Studies have shown that the preva[r] ...
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Alternative splicing and extra-telomeric role of telomerase reverse transcriptase isoforms in human embryonic stem cells
... The telomerase RNP complex plays a crucial role in maintaining telomere ...of telomerase catalytic subunit hTERT and its significance in extra- telomeric functions in modulating cellular ...
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Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
... The transcriptional controlling of h TERT gene is complex and includes regulation at multiple levels by various posi- tive and negative factors or pathways. Recent knowledge has come from the cloning of h TERT promoter ...
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Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression
... Figure 6. TERT activates RNA pol III– driven promoters by directly interacting with RPC32. (A) 293T cells were trans- fected with vector, TERT, or RPC32, along with tRNA promoter–driven luciferase vectors. Forty-eight ...
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Investigating the Protective Effects of Telomerase Reverse Transcriptase on Neuronal Metabolism and Resistance to Amyloid-beta
... transcription factors c-Myc, Sp1 and NF-κB, thereby increasing TERT expression and telomerase activity in spinal cord motor neurons undergoing injury 99 . This confers resistance to apoptosis mediated through ...
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Diverse regulatory manners of human telomerase reverse transcriptase
... Several agents can regulate the hTERT promoter activ- ity via acetylation or deacetylation. The HDACi TSA en- hances histone acetylation at the proximal promoter region of hTERT, and directly transactivates the hTERT ...
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INSILICO SCREENING OF NNRTI AS POTENTIAL TARGETS FOR TUMOR CONTROL
... the reverse transcriptase activity of telomerase in transformed ...of telomerase also implies the importance of those regions in reverse transcriptase ...target telomerase ...
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Original Article TERT rs2736098 polymorphism and bladder cancer risk: a meta-analysis
... human telomerase reverse transcriptase (TERT) gene variant rs2736098 polymorphism and bladder cancer risk, but the sample size has been small and the results were ...
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