Telomerase rna
Targeting Human Telomerase RNA via Biochemical and in vitro Selection Methods
... the RNA-RNA interaction, as evidenced by the stem mutant data, altering the ...the RNA-RNA ...mammalian telomerase RNA reduces telomerase activity, suggesting that ...
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Clinical significance of combined detection of human papilloma virus infection and human telomerase RNA component gene amplification in patients with squamous cell carcinoma of the esophagus in northern China
... human telomerase RNA component (hTERC) gene amplification in tissues derived from esophageal cancer, in esophagus displaying atypical hyperplasia and in normal tissue, and to analyze the relationship ...
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Involvement of the Oncoprotein c-Myc in Viral Telomerase RNA Gene Regulation during Marek's Disease Virus-Induced Lymphomagenesis
... viral telomerase RNA subunit (vTR) that exhibits 88% sequence identity to its chicken ortholog ...minimal telomerase ribonucleoprotein complex consists of a protein subunit with reverse transcriptase ...
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Identification of the Telomerase RNA in the Filamentous Fungus Aspergillus oryzae
... total RNA from Schizosaccharomyces pombe was run on a northern blot and then probed for the TER1 sequence (the telomerase RNA), a major band of about 1200 bp was indicated with less intense bands at ...
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Structure of the Tetrahymena thermophila telomerase RNA helix II template boundary element
... of telomerase activity compared with other ...T.thermophila telomerase RNP holoenzyme has been characterized by affinity purification and consists of a catalytic protein component, TERT (telomerase ...
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A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria
... the telomerase RNA component is sufficient to result in shortened telom- eres both in autosomal dominant dyskeratosis congenita in humans and in mTerc +/- heterozygous mice ...
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The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells
... lower telomerase RNA accumulation, reduced telomerase activity and subsequent telomere ...the telomerase complex in cells [7, 8, 60, ...active telomerase complex with hTERT in cells may ...
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Structure and function of Tetrahymena thermophila telomerase RNA
... yeast telomerase RNA secondary structure was independently proposed by four different research groups (Chappell and Lundblad 2004; Dandjinou et ...utilized RNA folding programs combined with ...
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Human telomerase RNA component (hTERC) gene amplification detected by FISH in precancerous lesions and carcinoma of the larynx
... ase RNA component (hTERC) gene, localized on chro- mosome 3q26, encodes the RNA component of human telomerase, and acts as a template for the addition of the repeat sequence ...
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5587.pdf
... However, telomerase RNAs identified to date harbor more than one telomere repeat of complementary sequence, which allows for primer ...promote telomerase processivity, where one telomere is elongated for ...
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Abnormal Micronuclear Telomeres Lead to an Unusual Cell Cycle Checkpoint and Defects in Tetrahymena Oral Morphogenesis
... to telomerase and the role of telomere binding proteins, but they have not been used to explore how a downstream morphogenic event is related to the mutated telomeric ...a telomerase RNA mutation ...
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Expression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells
... called telomerase to solve this ...active telomerase adds up some nonfunctional DNA repeats to the telomeric ends, to keep the critical length of DNA during multiple cell divisions ...of telomerase ...
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Dynamics of Telomeric DNA Turnover in Yeast
... its RNA subunit as a ...lactis telomerase RNA gene (TER1) tem- ...by telomerase but that there are other processes that also contribute to ...
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The Est1 Subunit of Saccharomyces cerevisiae Telomerase Makes Multiple Contributions to Telomere Length Maintenance
... the telomerase RNA. (A) Plasmids expressing A previously proposed RNA recognition motif in Est1 either the tagged Est1-myc 18 protein or the untagged Est1 is not required for association with ...
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Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer
... human telomerase RNA (hTR), human telomerase reverse transcriptase (hTERT) and CDC28 protein kinase regulatory subunit 2 (CKS2) in bladder carcinogenesis and their possible clinical significance; ...
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Identifying cancer-causing noncoding RNAs
... than telomerase activity or hTERT expression (Brown et ...erase RNA levels did not parallel the amount of telomerase activity detected (Blasco et ...lacked telomerase activity, ...
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The RNA Subunit of Telomerase Is Encoded by Marek's Disease Virus
... The high degree of similarity between the primary sequences of vTR and cTR genes was also reflected in their overall secondary structures (Fig. 4A). However, most of the muta- tions and deletions scattered along the vTR ...
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Tetrahymena Mutants With Short Telomeres
... three telomerase RNA template muta- Several other mutant transfomants became tgi when tions resulted in lethal phenotypes, and the only cells their telomeres elongated after losing the injected tgi1-1 that ...
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Medaka tert produces multiple variants with differential expression during differentiation in vitro and in vivo
... the telomerase RNA (TR) subunit that contains a template region com- plementary to the telomeric sequence for reverse transcription ...with telomerase activity [15], whereas TR is ubiquitously ...
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Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein
... the telomerase enzyme activity in primary epithelial cells by an unknown ...increases telomerase hTERT gene transcription coordinately with E6-induced telomerase ...
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