TGF-beta receptor signaling
Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture
... (Cell Signaling Technology, ...(Cell Signaling Technology, ...(Cell Signaling Technology, Inc.); and 1:3000 for anti-TGF-β3 (Genex Bioscience ...FGF-2, TGF-β3, Smad-2, and MAPK44/42; or ...
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Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling
... by TGF-β1, differentiate into myofibroblasts characterized by the de novo expres- sion of cytoskeletal and contractile proteins, modified focal adhesion complexes [15], and components of the extracellular matrix ...
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Fluid shear stress-induced TGF-beta/ALK5 signaling in renal epithelial cells is modulated by MEK1/2
... downstream signaling pathways, for instance affecting the hedgehog (Hh), epidermal growth factor receptor (EGFR), Wnt and transforming growth factor β (TGF-β) pathways [3, ...different ...
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TGF-beta and BMP in breast cancer cell invasion
... and TGF‐‐induced invasion in this spheroid model is dependent on the TRI ...IB receptor (ActRIB) and ac vin receptor‐like kinase (ALK)7 ...inhibited TGF‐b‐induced invasion of M1, M2 and M4 ...
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Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-induced rats through blocking TGF-β1/Smad7 signaling
... Moreover, TGF- β 1 is also involved in tubule glomerular sclerosis and podocyte apoptosis in ...block TGF- β 1/ Smad signaling by binding to Smurf2 to form an E3 ubiquitin ligase that targets the ...
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Dynamic expression of Endoglin, a TGF beta co receptor, during pre circulation vascular development in chick
... mediated TGF- β signaling cas- cade regulates the molecular cues involved in the terminal fate choice of endothelial progenitors to adopt a differentiated endo- thelial morphology via the initiation of ...
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The TGF beta type III receptor is localized to the medial edge epithelium during palatal fusion
... endogenous TGF- β 3. One conceivable mechanism is that restricted expression of TGF- β receptors (T β Rs) in a subpopulation of cells may localize TGF- β responsiveness (Brown et ...However, ...
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Decreased type II/type I TGF beta receptor ratio in cells derived from human atherosclerotic lesions Conversion from an antiproliferative to profibrotic response to TGF beta1
... by TGF-beta1, a potent wound healing agent, and show little induction of collagen synthesis to TGF-beta1, yet cells grown from human vascular lesions are growth stimulated by TGF- beta1 and markedly ...
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Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells
... Expression of AnxA1 Induces an EMT-Like Switch by Activation of the TGFβ Pathway. Next, we considered whether AnxA1 expression in a typical luminal-like breast cancer cell line that has low AnxA1 expression, would induce ...
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Cytokine expression & TGF-beta signaling in cervical cancer
... of TGF-β on the genome-wide mRNA expression profile of cervical cancer cell lines with different sensitivity to TGF-β in Chapter Chapter Chapter Chapter Chapter 4 44 ...to TGF-β-induced growth ...
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Human epithelial type ovarian tumour marker beta 2 microglobulin is regulated by the TGF β signaling pathway
... the TGF-β signaling pathway. Our recent study has shown that TGF-β1 regulates cystatin B, a progression marker of human epithelial ovarian tumour, in OC cells ...that TGF-β modulates serous ...
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TGFβ signaling supports survival and metastasis of endometrial cancer cells
... factor beta (TGF β ) type II receptor (RII) with microsatellite instability revealed a signifi cant molecular mechanism of tumorigenesis and tumor progression in gastrointestinal carcinomas with DNA ...
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Integrin mediated type II TGF β receptor tyrosine dephosphorylation controls SMAD dependent profibrotic signaling
... prevent receptor tyro- sine kinase–mediated ...tyrosine receptor kinase phosphorylation ...in TGF-β–driven fibrotic diseases, spermidine is not a selective TCPTP ...of TGF-β–mediated kidney ...
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<p>Silibinin Augments the Antifibrotic Effect of Valsartan Through Inactivation of TGF-β1 Signaling in Kidney</p>
... in TGF- β 1-treated HK-2 ...of TGF- β 1 signaling could promote the EMT process of ...that TGF- β 1 signaling could promote EMT process during the fi ...of TGF- β 1/Smad 2/3 ...
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Downregulation of miR-542-3p promotes cancer metastasis through activating TGF-β/Smad signaling in hepatocellular carcinoma
... The sequence of TGF- β 1 3 ′ UTR complementary to miR- 542-3p seed region was amplified from human genomic DNA. Then, the sequence was cloned into pGL3 luciferase reporter vector (Promega, Madison, WI, USA). The ...
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Regulation of TGF-β receptor activity
... MMP2. TGF- b can activate PKC ζ in a TRAF6-dependent manner, and PKC ζ in turn facilitates the TACE-mediated cleavage of T b ...attenuates TGF- b - induced invasiveness of breast MDA-MD-231 and lung A549 ...
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Identification of cellular target genes of the Epstein-Barr virus transactivator Zta: activation of transforming growth factor beta igh3 (TGF-beta igh3) and TGF-beta 1.
... a TGF-b1-responsive gene ...that TGF- b igh3 mRNA levels were induced ...of TGF- b 1 by Zta. Since TGF- b igh3 was isolated previously as an upregulated gene in an adenocarcinoma cell line ...
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TGF-beta Signaling in Control of Cardiovascular Function
... Furthermore, the ALK-5 and ALK-1 pathways have different effects on the expression and signaling of VEGF Liu et al., 2009; Shao et al., 2009, which together with differential binding of [r] ...
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Carbon nanotube-based substrates promote cardiogenesis in brown adipose-derived stem cells via β1-integrin-dependent TGF-β1 signaling pathway
... (Cell Signaling Technology) were used to incubate the polyvinylidene difluoride membrane with total ...block signaling mediated by β 1-integrin, which was shown by previous ...
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FKBP51 increases the tumour-promoter potential of TGF-beta
... the TGF-β and the pro angiogenic TGF-β re- ceptor type III (TβRIII) factors ...of TGF-β and TβRIII gene expression in A375 cell line (Figure 1A), which is in accordance with the upregulation of these ...
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