TGF-β/Smad pathway
Original Article Cross-talk between TGF-β/Smad pathway and Wnt/β-catenin pathway in pathological scar formation
... Abstract: TGF-β1 is a key factor in the process of wound healing, which is regulated by TGF-β/Smad ...that TGF-β1 contributed to pathological scar ...Wnt/β-catenin pathway ...
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The truncated mutant HBsAg expression increases the tumorigenesis of hepatitis B virus by regulating TGF β/Smad signaling pathway
... in TGF- β /Smad pathway was also ...of TGF- β 1 (increasing TGFBI level), the volume of tumor is obviously reduced in nude mice with injection of L02 cells stable expressing ...
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Increased Smad3 and reduced Smad2 levels mediate the functional switch of TGF-β from growth suppressor to growth and metastasis promoter through TMEPAI/PMEPA1 in triple negative breast cancer
... by Smad mediated TGF-β signaling in several biological functions, it has been noticed that dysfunction of TGF-β signaling pathway has been linked to diverse set of developmental ...
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Original Article PDK4 regulates human cardiomyocyte viability, apoptosis, and inflammatory response via inhibiting TGF-β/Smad signaling pathway
... the TGF-β/Smad ...or TGF-β/Smad pathway inhibitor (LY2157299) and a negative control group (cardiomyocytes transfected with shRNA scrambled sequence) was set ...and ...
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Original Article MicroRNA-27a adjusts diabetic nephropathy patients and inhibits TGF-β/Smad signaling pathway
... to human being [23]. It has been studied for years, and is shown to regulate cell prolifera- tion, differentiation and apoptosis through complicated receptor signal transduction path- ways on cell surface in the manners ...
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Matrine Suppresses Pancreatic Fibrosis by Regulating TGF β/Smad Signaling in Rats
... the TGF-β/ Smad pathway in pancreatic ...of TGF-β1, α-smooth muscle actin (α-SMA), and collagen I in pancreatic tissues was assessed by immunohistochemical ...of TGF-β ...
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TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion
... of TGF- β 2 on ...that TGF- β 2 activated autophagy in human glioma cell lines and knockdown of Smad2 or inhibition of c-Jun NH2-terminal kinase, attenuated TGF- β 2-induced ...
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Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice
... cells. TGF β is able to signal in endothelial cells via two pathways ...T β RI or ALK-5 and phosphorylation of Smad2 and Smad3, it has recently been dem- onstrated that TGF β might also ...
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Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF β/miR 195/Smad signaling pathway
... kines. TGF-β1/Smad pathway is a key signal pathway in promoting liver fibrosis ...[10]. TGF-β1 leads to excess collagen synthesis by phosphorylating Smad2L/C and Smad3C in ...by ...
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Original Article Effects of melatonin on diabetic nephropathy rats via Wnt/β-catenin signaling pathway and TGF-β-Smad signaling pathway
... and β-catenin in the model group were higher than the control group ...and β-catenin in the medium dose group and the high dose group were significantly lower than the model ...of TGF-β1, p-Samd2 and ...
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Original Article Inhibition of TGF-β-Smad signaling attenuates hyperoxia-induced brain damage in newborn rats
... of TGF-β in brain tissue under hyperoxia, neonatal rats were sub- jected to hyperoxic conditioning (80% O 2 ...for TGF-β analysis. As shown in Figure 1A, intra- cephalic TGF-β ...
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Effect of curcumin on an animal model with hepatic fibrosis via tgf β/smad signaling pathway
... fibrosis is regulated by a variety of cytokines and their molecular signaling pathways (Lee, 2015). Therefore, it is practical to block the progression from liver fibrosis to cirrhosis by interfering with signaling ...
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<p>G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer</p>
... In an in vitro assay, siRNA technology was used to effectively knock down the expression of G3BP1 in GC cell lines. Our fi ndings con fi rmed the outcomes of the study by Min et al, 5 which reported that C3BP1 is a potent ...
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Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells
... signaling pathway is ...signaling pathway participated in many physiological and pathological processes such as cell proliferation, differentiation, apoptosis, inflammation, and immune response by ...
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Non-degradative ubiquitination in Smad-dependent TGF-β signaling
... Wnt pathway in cochlea and floor plate ...in TGF-b signaling and to address its physiological function, we generated Smurf2-deficient ...various pathway components and transcriptional readouts in ...
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Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD independent TGF β signalling pathway
... the TGF-β ...of TGF-β signalling, are known to cause the aneurysm- osteoarthritis syndrome, presenting with early-onset polyarticular OA ...
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Angiotensin II–dependent TGF β signaling contributes to Loeys Dietz syndrome vascular pathogenesis
... the TGF-β pathway in aortic aneu- rysm. Upon TGF-β ligand binding to TβRII, TβRI (also known as ALK5) is recruited to and phosphorylated by ...of TGF-β signaling and that ...
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Hyperglycemia promotes Snail-induced epithelial–mesenchymal transition of gastric cancer via activating ENO1 expression
... [43]. TGF-β is a multifunctional cytokine that is involved in cancer pro- gression, including EMT, immune evasion, metastasis and chemotherapy resistance ...of TGF-β/Smad signaling ...
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Schisandrin B attenuates CCl<span style="font-size: 8.33333px">4</span>-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways
... (TGF- β )/Smad signaling ...inhibited TGF- β-induced HSC ...inhibited TGF-β1-stimulated phosphory- lation of Smad and signaling of mitogen-activated protein ...and ...
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Original Article Effects of 18α-glycyrrhizin on TGF-β1/Smad signaling pathway in rats with carbon tetrachloride-induced liver fibrosis
... which TGF-β expres- sion is dis-regulated in the liver by adenovirus or in transgenic mice have revealed the impor- tance of TGF-β in the HSC activation and fibro- genesis ...[24]. ...
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