TGF-β1
TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5
... of TGF-β signaling in mammalian cells ...of TGF-β1 in Aβ-injected rats ...on TGF-β1-suppressed microglia clustering and its concurrent effects on inhibiting SMAD2 phosphorylation and ...
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Association between mRNA Expression of Aromatase, 17β HSD2, Level of TGF β1 and Stage of Endometriosis
... of TGF- β1 and stage of ...and TGF-β1 serum and peritoneal fluid was checked using ...of TGF- β1 on en- dometriosis group was significantly higher compared to control group (p ...
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Downregulation of TGF-β1 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1/Smad3 signaling
... RNA from the cells was isolated using TRIzol reagent (Molecular Research Center, Cincinnati, OH, USA). Then, cDNA was synthesized using the RNA reverse transcription kit (Invitrogen). The Applied Biosys- tems 7300 qPCR ...
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T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer
... produce TGF-β1 and its production may further be upregulated in response to tumor development [34, ...of TGF-β1 is a major mechanism of T cell tolerance [44, ...form TGF-β1 in an ...
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MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression
... inhibited TGF-β1-induced EMT in GC After transfection of miR-21 inhibitors, the miR-21 expression of SGC-7901 and KATO-III cells in the miR-21 inhibitors group and miR-21 inhibitors + PTEN-siRNA group ...
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Original Article TGF-β1 induces airway smooth muscle cell proliferation and remodeling in asthmatic mice by up-regulating miR-181a and suppressing PTEN
... to TGF-β1 that made it an important subject of our ...and TGF-β1. Thus, ASMCs were stimulat- ed with TGF-β1 in different concentrations or for different times, and the expression ...
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TGF-β1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis
... of TGF-β1 on the expression of B7- H3 and B7-H4 in CRC cells, we treated HCT-116, LoVo, Caco-2, SW480, and SW620 cells, with recombinant human ...that TGF-β1 significantly elevated the ...
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Blocking Smad7 restores TGF β1 signaling in chronic inflammatory bowel disease
... of TGF- β 1 signaling, is overex- pressed in inflammatory bowel disease (IBD) mucosa and purified mucosal T ...exogenous TGF- β 1. TGF- β 1 cannot inhibit proinflammatory cytokine production in ...
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Naringenin prevents TGF β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation
... that TGF-β1 can induce an immunosuppressive microenvironment that promotes metastasis both in animal models and human cancer pa- tients [36, ...of TGF-β signaling may enhance anti-tumor immune ...
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Original Article Spatial and temporal expression of SP-B and TGF-β1 in hyperoxia-induced neonatal rat lung injury
... Total proteins were extracted from lung tissue samples by using lysis buffer (Beyotime, Shanghai, China). Protein samples were mixed with a sample buffer (Beyotime) and boiled for five minutes. Equal amounts of protein ...
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Original Article MicroRNA-142-3p inhibits high-glucose-induced endothelial-to-mesenchymal transition through targeting TGF-β1/Smad pathway in primary human aortic endothelial cells
... EndMT. TGF-β1 has been found to be one of the molec- ular mediators involved in the progression of EndMT ...that TGF-β1 was a downstream target of miR-142- 3p and overexpression of ...
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Original Article Salidroside alleviates paraquat-induced rat acute lung injury by repressing TGF-β1 expression
... [20]. TGF-β1 plays a critical role in tissue injury development of mul- tiple organs, including lung ...of TGF-β1 is dramatically increased as early as 2 days after the lung injury, which is a ...
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Original Article Characteristics of core fucosylation changes of TGF-β1-induced pericyte tranformation in mouse lungs
... pericyte transformation following stimulation with TGF-β1 for 24 h and 48 h. The relationship between the core fucosylation and PDGFβR in pericytes remains unclear. The results of the immunofluorescence ...
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Original Article DIM attenuates TGF-β1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts
... AKT/GSK-3β signaling pathways was associat- ed with cardiac hypertrophy [25], epithelial to mesenchymal transition [26, 27], and cell cycle [28]. GSK-3β, the downstream target of AKT, had proved that the roles of GSK-3β ...
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TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
... (TGF-β1, TGF-β2 and TGF-β3) in mammals. All TGF-β precursor forms are secreted as latent homodimeric complexes, incorporated into the ECM, and activated by proteolytic cleavage ...the ...
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Human cytomegalovirus promotes the activation of TGF-β1 in human umbilical vein endothelial cells by MMP-2 after endothelial mesenchymal transition
... activated TGF-β1 decreased by 60% when the HUVECs were treated with GM6001 (p < ...activated TGF-β1 decreased by 9% when the HUVECs were treated with aprotinin (p > ...activated ...
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Label-free quantitative proteomics identifies transforming growth factor β1 (TGF-β1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells
... importantly, TGF-β1 down- regulated the mRNA and protein levels of Axin2 and facilitated the translocation of β-catenin into the ...of TGF-β1 on OP9-DL1 adipocyte ...that TGF-β1 ...
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GENE POLYMORPHISM OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-Β1) AND ITS LEVEL IN RHEUMATOID ARTHRITIS PATIENTS ASSOCIATED WITH OSTEOPOROSIS DISEASE
... for TGF-β1 G/A800 polymorphism the region surrounding the polymorphism was amplified with following forward primers 5' – GTTGGCGAGAACAGTTGGC-3' and the reverse primer 5' –GAAAGGACAGAAGCGGTGC-3' ...for ...
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Distinct mechanisms of TGF β1–mediated epithelial to mesenchymal transition and metastasis during skin carcinogenesis
... Cruz Biotechnology Inc.). Blocking peptides specific for each antibody were included as negative controls. Cell adhesion molecules in mouse tumor samples were stained as previously described (6), using antibod- ies ...
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Blood pressure homeostasis is maintained by a P311–TGF β axis
... paraffin-embedded human tissues. 5-μm tissue sections were incubated with anti-mouse P311 Ab (1:50 dilution; ref. 44), anti-human P311 Ab (1:50 dilution; ref. 45), anti–TGF-β1-3 Ab (1:20 dilution; MAB1835; ...
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