The dentate gyrus
Adult neurogenesis modifies excitability of the dentate gyrus
... Adult-born dentate granule neurons contribute to memory encoding functions of the dentate gyrus (DG) such as pattern ...mature dentate granule neurons in the DG of mice with more adult-born ...
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Functional synaptic plasticity in the dentate gyrus of the rat hippocampus
... the dentate gyrus, where the cell bodies form a discrete layer and many granule cells are activated in synchrony, the granule cell population spike is recorded negative at the cell layer or in the hilus and ...
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Normal And Epilepsy-Associated Pathologic Function Of The Dentate Gyrus
... of dentate granule cells combine to make these neurons fundamentally reluctant to activate, one of their hallmark ...the dentate gyrus is one of the more heavily inhibited regions of the brain, with ...
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ApoE is required for maintenance of the dentate gyrus neural progenitor pool
... the dentate gyrus, ApoE expression level is low and the neural stem and progenitor cells quickly proliferate and differentiate into the granular neurons of the dentate ...the dentate ...
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Neurogenin 2 has an essential role in development of the dentate gyrus
... the dentate gyrus Christophe Galichet, François Guillemot* and Carlos ...The dentate gyrus (DG) of the hippocampus has a central role in learning and memory in adult ...
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Hippocampus-based contextual memory alters the morphological characteristics of astrocytes in the dentate gyrus
... term memory induction in the dentate gyrus of the hippo- campus. We exposed Fvb/n mice to contextual fear condi- tioning, and checked for morphological and molecular changes in astrocytes. We found that 1 h ...
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The effect of Urtica dioica extract on the number of astrocytes in the dentate gyrus of diabetic rats
... Diabetes mellitus is associated with cerebral alterations in both human and animal models of the disease. These alterations include abnormal expression of hypothalamic neuropeptides and hippocampal astrogliosis. Urtica ...
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Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
... Previous studies have used irradiation or antimitotic agents such as MAM to suppress adult neurogenesis in rodents. Such manipulations have impaired learning in trace eye-blink 14 and fear 15 paradigms. Similar ...
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Thioperamide-induced Antinociception is Mediated through Endogenous Opioid System in the Dentate Gyrus of Adult Rats
... Intra-dentate gyrus microinjections of thioperamide (2 and 4 µg) significantly (P < ...the dentate gyrus non-significantly increased the intensity of ...the dentate gyrus, ...
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Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus
... This is the Accepted Version of a paper published in the journal: National Academy of Sciences Saunderson, Emily A., Spiers, Helen, Mifsud, Karen R., Gutierrez-Mecinas, Maria, Trollope, Alexandra F., Shaikh, Abeera, ...
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The granule cell density of the dentate gyrus following administration of Urtica dioica extract to young diabetic rats
... The rats of the treatment groups showed no ev- idence of granule cell loss, indicating that therapeu- tic use of nettle extract may have significant regen- erative effects on the granule cells and their pro- genitors. It ...
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Role of the 5-HT4 receptor in chronic fluoxetine treatment-induced neurogenic activity and granule cell dematuration in the dentate gyrus
... Yuki Imoto 1 , Toshihiko Kira 1 , Mamiko Sukeno 1 , Naoya Nishitani 2 , Kazuki Nagayasu 2 , Takayuki Nakagawa 2 , Shuji Kaneko 2 , Katsunori Kobayashi 3,4 and Eri Segi-Nishida 5* Abstract Background: Chronic treatment ...
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Change in platelet endothelial cell adhesion molecule-1 immunoreactivity in the dentate gyrus in gerbils fed a folate-deficient diet
... [7] reported that folate deficiency in the mouse increased homocysteine level in the serum and cerebral lesion volume. In the present study, we observed that PECAM-1 immunoreactivity and protein level in the ...
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Minocycline but not valproic acid influence the density of NogoA-immunoreactive neurons in the hilus of the dentate gyrus of the rats subjected to intracerebral haematoma
... the dentate gyrus (HDG) to many brain insults we decided to study the effect of experimentally induced intracerebral haematoma on density of neurons ex- pressing NogoA protein in ...contralateral ...
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Smad3 is required for the survival of proliferative intermediate progenitor cells in the dentate gyrus of adult mice
... In the rostral portion, the in- crease in proliferation, and in cell cycle exit, induced by Smad3 deficiency was not translated into a clear increase in newborn neurons, probably due to [r] ...
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FGF 2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice
... Introduction It has long been believed that the brain regenerates poorly after injury. However, this idea has been chal- lenged by recent data showing that mammalian neural progenitor cells can proliferate and ...
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Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus
... Conclusions Here we found that the N595Q substitution in GluN2A reduced the Mg 2+ block of NMDAR-mediated synaptic currents in dentate granule cells and facilitated activity- dependent synaptic potentiation at the ...
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Validation of reference genes for quantitative real time PCR studies in the dentate gyrus after experimental febrile seizures
... The geNorm algorithm provides a measure of gene expression stability (M value) and determines the optimal number of reference genes using pairwise variation (V) analysis.. In contrast to[r] ...
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NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice
... in dentate gyrus granule cells of adult mice, we used conditional knockout mouse lines for the subunits GluN1, GluN2A and ...in dentate gyrus granule cells after chronic A β -overproduction in ...
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Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit
... Mistry et al., 2011). However, more recent studies provide evidence for subpopulations of granule cells that fire with more unimodal low frequency firing rates (Mistry et al., 2011), with electrophysiological and ...
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