The HLA Class II antigen processing pathway
Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing
... of HLA class II molecules constitutively, with elevated levels seen in the set- ting of mucosal inflammation including inflammatory bowel ...the HLA class II antigen ...
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Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells
... of HLA class II an- tigen processing and presentation by ...express HLA-DR molecules, we demonstrate the restricted expression of HLA class II antigens at the ...
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Melanosomes and MHC Class II Antigen-Processing Compartments
... biosynthetic pathway to the endosomal system, the role of the transport machinery in establishing these routes, and the mechanisms by which tumor antigens are presented to the T cell arm of the immune ...
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HLA class II restricted minor histocompatibility antigens - identification, processing and biology
... of HLA class II epitopes has been further confirmed by our T-cell library experiments as well as an earlier mouse study, 31 showing that at least a quarter of undefined self-antigens in natural ...
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Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
... MHC class II ...nuclear antigen 1 (EBNA1) was found to gain access to this pathway by ...cell antigen of latent Epstein-Barr virus infection, slowly accumulated in cytosolic ...
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Footprints of antigen processing boost MHC class II natural ligand predictions
... MHC class II binding prediction and/or in vitro binding assay methods, since researchers could use these tools to select which peptides to include in a T cell epitope screening or to define the MHC ...
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HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation
... tion of whether the DM-bound MHC-II intermediate contains one (destabilized) peptide [ 2 ,6 ], two (partially bound) peptides [ 28,29 ], or no peptide at all [ 3 ,7 ], remains to be established. Besides ...
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Human histocompatibility leukocyte antigen (HLA) haplotype frequencies estimated from the data on HLA class I, II, and III antigens in 111 Japanese narcoleptics
... K Matsuki, … , M Satake, Y Honda J Clin Invest. 1985;76(6):2078-2083. https://doi.org/10.1172/JCI112211. In order to deduce the predominant haplotypes in Japanese narcoleptics, we have studied a total of 111 Japanese ...
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Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients
... of HLA on the surface of tumor cells has been observed in various types of human malignancies, including cHL ...of HLA antigen by tumor cells is quite common in EBV-neg cHL, since ...expressed ...
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The involvement of heat shock protein molecular chaperones in MHC class II antigen processing and presentation
... of antigen, the chaperone's requirement for binding and efficient release of antigen is superceded by the sheer abundance of ...When antigen is present in copious amounts, a sufficient concentration ...
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HLA-DRB1 Class II antigen level alleles are associated with persistent HPV infection in Mexican women; a pilot study
... of HLA class II genes in the fate of the viral ...that class I genes are very important in the immune response because of their involvement in antigen presentation of viral peptides on ...
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Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope
... an HLA-DR1 ⫹ donor, enriched for CD4 ⫹ cells by mag- netic microbead separation (Miltenyi Biotec), and expanded using human T-activator CD3/CD28 Dynabeads 威 (Life Tech- nologies) at a cell to bead ratio of 1:2 for ...
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HLA Class II Polymorphisms and Susceptibility to Recurrent Respiratory Papillomatosis
... in HLA class II anti- gen processing by demonstrating that PBMC from the most severely affected patient in this study were capable of present- ing both L1 and p139 to two DRB1*0301-positive ...
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The interaction of HLA-DM with conventional MHC class II molecules
... The antigen-presenting cells o f these m ice show ed s e v e re ly co m p ro m ised a n tig e n -p re se n tin g c a p a c itie s, the M H C c la ss II m o lecu les w ere S D S -u n stab le and C L IP -lo a ...
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The impact of HLA-DM on peptide binding to MHC class II
... 2 HLA-DM Influences Epitope Selection by Favoring the Survival of Structurally Restrained Peptide-MHC Class II Complexes1 ...Abstract HLA-DM (DM) plays a critical role in generating the ...
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HLA Class II Profile and Distribution of HLA-DRB1 and HLA-DQB1 Alleles and Haplotypes among Lebanese and Bahraini Arabs
... leukocyte antigen class II allele fre- quencies and haplotype association in Iranian normal ...2001. HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and ...
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The class I and class II antigen systems in cattle and their association with disease
... Although DR antigens were f i r s t discovered through th e ir asso cia tion to MLR, the actual details of th is relationship are not yet established. The existence of DR antigens was f i r s t demonstrated by the in h ...
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Identification of amino acids in antigen-binding site of class II HLA proteins independently associated with hepatitis B vaccine response
... in HLA-DR b1 and the HBV vaccine ...of HLA- DR b1 was commonly carried in the protective alleles, such as HLA-DRB1 ⁄ 01:01 and ⁄ 12:01, whereas the risk direction alleles, ...i.e., HLA-DRB1 ⁄ ...
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Aspects of the cell biology of antigen processing for MHC II
... in processing, for example Y-Ae expression in the thymus (Murphy et aL, ...of processing is the varying requirement for ...MHC II are both delivered into early endosomes, where proteolytic activity ...
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The systems biology of MHC class II antigen presentation
... MHC-II Antigen Presentation Although the system of antigen presentation is understood at a high level of detail, this in fact only represents sketches of the total ...MHC-II antigen ...
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