The host protein CTCF – properties and functions
Viral Exploitation of Host SOCS Protein Functions
... of host proteins known as suppressors of cytokine signaling (SOCS) have emerged as frequent targets of viral ...robust host SOCS protein expression following infection, essentially “hijacking” SOCS ...
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The Baculovirus Antiapoptotic p35 Protein Functions as an Inhibitor of the Host RNA Interference Antiviral Response
... ABSTRACT RNA interference (RNAi) is considered an ancient antiviral defense in diverse organisms, including insects. Virus infections gen- erate double-strand RNAs (dsRNAs) that trigger the RNAi machinery to process ...
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Pathogenic functions of host microbiota
... Raw reads of all samples were downloaded from the European Nucleotide Archive (http://www.ebi.ac.uk/ena) and the Sequence Read Archive (https://www.ncbi.nlm.- nih.gov/sra), quality filtered for an average Q score ≥ 20 ...
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CTCF Binding Sites in the Herpes Simplex Virus 1 Genome Display Site-Specific CTCF Occupation, Protein Recruitment, and Insulator Function
... cell-type-specific functions in neurons and fibroblasts (30). Further, CTCF interacts with the large subunit of RNA polymerase II (RNA Pol II) for the activation of transcription in mammalian cells (24), and ...
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Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development
... of CTCF-depleted one-cell embryos were exchanged with maternal pronuclei of control one-cell ...unmanipulated CTCF-depleted embryos were at the two-cell ...among CTCF- depleted embryos did not affect ...
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The Exonuclease and Host Shutoff Functions of the SOX Protein of Kaposi's Sarcoma-Associated Herpesvirus Are Genetically Separable
... normal host mRNA degradation ...wild-type host shutoff activity, suggest- ing that nuclear localization is not critical for this ...for host proteins that interact biochemically or func- tionally ...
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Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster
... diverse functions, we have begun an analysis of the Drosophila CTCF ...(dCTCF). CTCF is one of the few insulator proteins known to be conserved from flies to ...dCTCF protein interaction ...
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Human Adenovirus Core Protein V Is Targeted by the Host SUMOylation Machinery To Limit Essential Viral Functions
... that protein V SUMOylation reduces virus growth; hence, protein V SUMOylation represents an important novel aspect of the host antiviral strategy to limit virus replication and thereby points to ...
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Depletion of the Insulator Protein CTCF Results in Herpes Simplex Virus 1 Reactivation In Vivo
... down host and/or viral proteins in order to define their roles in the establishment, maintenance, and reactivation from latency in vivo in the absence of global pleotropic ...that CTCF dissociation drives ...
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The Insulator Protein CTCF Is Required for Correct Hox Gene Expression, but Not for Embryonic Development in Drosophila
... mammals. CTCF is essential for mammalian cell viability and is an important regulator of genome ...flies, CTCF is both maternally deposited and zygotically ...zygotic CTCF die as young adults with ...
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Identification of protein functions using a machine-learning approach based on sequence-derived properties
... of protein function is SVM ...the functions of homodimeric, drug absorption, drug delivery, drug excretion, and RNA- binding proteins, among others, has been proposed by Cai et ...of protein function ...
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Training host pathogen protein–protein interaction predictors
... physiochemical properties that affect protein interactions such as side chain volume and dipoles 17 ...each protein sequence to get a 7 3 = 343 dimensional protein-level feature ...a ...
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Computational prediction of host-pathogen protein-protein interactions
... interacting protein pairs (positive class) and the non-interacting protein pairs (negative ...interacting protein pairs from non-interacting ones is ...for host- pathogen interaction ...
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Transient expression of βC1 protein differentially regulates host genes related to stress response, chloroplast and mitochondrial functions
... Saiqa Andleeb, Imran Amin, Aftab Bashir, Rob W Briddon, Shahid Mansoor * Abstract Background: Geminiviruses are emerging plant pathogens that infect a wide variety of crops including cotton, cassava, vegetables, ...
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CTCF: Master Weaver of the Genome
... the CTCF consensus, but may not directly interact with CTCF, might also affect loop for- ...a CTCF-binding site adja- cent to a thyroid hormone response element (TRE) that show enhancer blocking ...
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Epstein-Barr Virus Rta-Mediated Accumulation of DNA Methylation Interferes with CTCF Binding in both Host and Viral Genomes
... IMPORTANCE CTCF is a multifunctional protein that variously participates in gene expression and higher-order chromatin structure of the cellular and viral ...genome, CTCF occupancy and DNA ...
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ERp57/GRP58: A protein with multiple functions
... precursor protein in brain tissues and are responsible for the formation of the soluble fibrillar aggregates followed by the insoluble fibrillar precipitates, which constitute the plaques typical of Alzheimer's ...
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Towards data analytics of pathogen-host protein-protein interaction: a survey
... knowledge. Protein-protein interaction is one of the main areas in bioinformatics as it is the basis of the biological ...pathogen-host protein- protein interactions, which would be ...
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CGGBP1 regulates CTCF occupancy at repeats
... repeat-binding protein and changes in repeat-silencing modification H3K9me3 as an effect of CGGBP1 knock- down is not ...CGGBP1-regulated CTCF-binding ...the CTCF-binding site flanks in CT and KD. At ...
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CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites
... only CTCF fragments containing zinc fingers 7 11 could be targeted to centromeres in mitotic cells already suggested that these sites might be ...engage CTCF zinc fingers 7–11 and 8–11 (Figure 4D; Figure ...
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