The insulin receptor and insulin function
Mosaic analysis of insulin receptor function
... USA Insulin promotes both metabolism and ...whether insulin-dependent growth is merely a result of its metabolic ...of insulin receptor (Insr) has not clar- ified this issue, because of early ...
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Expression and function of the insulin receptor substrate proteins in cancer
... Conclusion The IRS proteins have been implicated in contributing to all stages of cancer, from initiating events to metastatic progression. However, there is still much to be learned about the mechanisms by which each of ...
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Insulin receptor of human cerebral gliomas Structure and function
... The insulin receptor from human brain tumors of glial origin was examined for the first time using intact cells (from an established cultured human glioblastoma cell line) and partially purified solubilized ...
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Insulin receptor signaling in the development of neuronal structure and function
... a function of insulin receptor signaling in synapse formation or synapse ...If insulin receptor signaling promotes synapse formation, disrupting insulin receptor signaling ...
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The role of c-Kit and insulin receptor tyrosine kinases in beta cell function and insulin secretion
... and insulin secretion seen in younger ...and insulin secretion may be beneficial under transient conditions, chronic insulin signalling may result in complications including insulin resistance ...
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Brain Insulin Resistance: Focus on Insulin Receptor- Mitochondria Interactions
... biological function of the IR ...the receptor kinase activity [65]. However, it was questionable how insulin binding can induce the autophosphorylation of A-loop tyrosines if both active sites of the ...
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Effects of nano-curcumin on gene expression of insulin and insulin receptor
... improved insulin sensitivity, and hypoinsulinemia (Peeyush et ...and insulin sensitivity, which have been extensively studied (Chanpoo et ...islet function, which results in increased pancreatic ...
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The role of insulin receptor substrate 2 in hypothalamic and β cell function
... to insulin and MTII, which suggests that they could be mediating the effects of insulin in the CNS in a mela- nocortin-sensitive neuronal ...and insulin hyper- polarized POMC ...
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The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila
... the insulin/insulin- like growth factor signaling pathway prolongs lifespan, and mutations in the insulin receptor substrate Chico extend the survival of mutant flies against certain bacterial ...
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The insulin and insulin-like growth factor receptor family in neoplasia: an update
... the insulin receptor, but also of other receptor tyrosine ...other receptor tyrosine kinases, as well as signals that result from activating PI3K ...drug-induced insulin resistance. A ...
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Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice
... the insulin signaling pathway is the insulin receptor (IR), a protein tyrosine kinase that, when activated by insulin binding, undergoes autophosphorylation and phosphorylates several intra- ...
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Investigation of Pancreatic -Cell Insulin Receptor Regulation of Investigation of Pancreatic -Cell Insulin Receptor Regulation of -Cell Growth, Function, and Survival Via a Temporal Conditional Knockout
... essential prenatal pancreatic development and postnatal remodelling, causing these mice to exhibit early age-dependent β-cell dysfunction. In contrast, we induced β-cell Ir knockout in adult mice after postnatal ...
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RENAL FUNCTION IMPAIRMENT IN INSULIN DEPENDENT AND NON INSULIN DEPENDENT DIABETIC PATIENTS
... Moreover the blood pressure control has been a challenge for health care professionals in checking their patients towards diabetic vascular complications. It is recommended that hard line antihypertensive treatment, and ...
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A review on insulin presence and function in brain
... is insulin. Insulin activity in the periphery has been the subject of study since long time ago, though, beginning to understand the central activity of insulin is rather recent and because of ...
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Transgenic rescue of insulin receptor–deficient mice
... in insulin action and their contribution to the pathogenesis of diabetes remain ...of insulin receptors causes early postnatal death from diabetic ...of insulin receptor function in ...
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Tissue specific insulin resistance in mice with mutations in the insulin receptor, IRS 1, and IRS 2
... and function in double and triple heterozygous ...to insulin resistance is different in the 3 sets of mice with ir and irs-1 and/or irs-2 ...because insulin resistance is not as pro- found as in ...
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Original Article Propofol inhibits growth of neurons through regulating insulin receptor and insulin-like growth factor-1 receptor
... the insulin receptor (IR) and Insulin-like growth factor-1 receptor ...in receptor level of IR and IGF-1R, propofol activated PI3K-AKT signal and decreased the sensitivity of ...
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Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation
... cav-2 function as a substrate for IR tyrosine kinase and IR-cav-2-IRS-1-directed activation of mitogenic and metabolic insulin signaling We next explored requirement of cav-2 fatty acylation for its cataly- ...
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The insulin receptor and the molecular mechanism of insulin action
... Tyrosine kinase activity ofthe insulin receptor of patients with Type A extreme insulin resistance: studies with circulating mononuclear cells and cultured lymphocytes. Decreased insulin[r] ...
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Autoantibodies to the Insulin Receptor: EFFECT ON THE INSULIN RECEPTOR INTERACTION IN IM 9 LYMPHOCYTES
... with insulin-resistant “diabetes” contains antibodies that bind to and block the cell membrane receptors for ...its receptor on the human lymphoblastoid cell line ...specific insulin binding can be ...
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