The long noncoding RNA Malat1
Induction of long noncoding RNA MALAT1 in hypoxic mice
... Abstract: Long thought to be “junk DNA”, in recent years it has become clear that a substan- tial fraction of intergenic genomic DNA is actually transcribed, forming long noncoding RNA ...of ...
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Long noncoding RNA MALAT1-regulated microRNA 506 modulates ovarian cancer growth by targeting iASPP
... to MALAT1 knockdown by si-MALAT1, while it was promoted in response to iASPP overexpression; the inhibitory effect of si-MALAT1 on SKOV3 and A2780 cell growth was partly restored by iASPP ...
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Targeting the long noncoding RNA MALAT1 blocks the pro-angiogenic effects of osteosarcoma and suppresses tumour growth
... messenger RNA, mRNA) and non-coding RNAs (ncRNAs) [12]. Among the ncRNAs, long non-coding RNAs (lncRNAs), defined as ncRNAs with at least 200 nucleotides and without apparent protein-coding capability [13, ...
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Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma
... that MALAT1 was aberrantly up-regulated in multiple cancerous tissues and conferred proliferative and metastatic phenotypes to tumor cells ...decreased MALAT1 level [16], which indirectly implicated that ...
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Knockdown of long noncoding RNA Malat1 aggravates hypoxia-induced cardiomyocyte injury by targeting miR-217
... Fig. 3. Effects of suppression of Malat1 on hypoxia- induced H9c2 cell injury. (A) quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of Malat1 after sh- ...
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<p>Long Noncoding RNA MALAT1 Promotes the Development of Colon Cancer by Regulating <em>miR-101-3p</em>/STC1 Axis</p>
... of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) on CC progression and the potential ...of MALAT1, microRNA (miR)-101-3p, and stanniocalcin ...
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Long Noncoding RNA MALAT1 Regulates Hepatocellular Carcinoma Growth Under Hypoxia via Sponging MicroRNA 200a
... of MALAT1 containing putative miR-200a binding site and its mutated (MUT) seed sequence were purchased from Shanghai Bioengineering ...as MALAT1- WT and MALAT1-MUT, ...with MALAT1-WT or ...
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Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells
... The subcellular localization of the MALAT1 cells was identified through the application of FISH as per the instructions of the Ribo™ lncRNA FISH Probe Mix (Red) Kit (Ribobio Co., Ltd., Guangzhou, Guangdong, ...
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Evaluation of long noncoding RNA MALAT1 as a candidate blood based biomarker for the diagnosis of non small cell lung cancer
... biomarker MALAT1 does not fulfill both ...of MALAT1 as a single biomarker for the diagnosis of NSCLC, particularly for the subtype AdCa ...verify MALAT1 in combination with other biomarkers in larger ...
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The long noncoding RNA MALAT1 predicts human islet isolation quality
... as MALAT1, which could facilitate the prediction of islet isolation quality, within minutes of receiving the cadaveric ...measure RNA in ...of RNA quantity (42) and can be used to measure biomarker ...
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Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury
... of MALAT1 (TEdM) ...of MALAT1 showed a slightly higher average radiant effi- ciency while following the same trend as exosome-treated animals, but this did not achieve ...
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Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury
... of Malat1 in macrophage activation, we initially examined the regulation of its expression by LPS and IL-4, which are classically used to induce the 2 polarized states of macrophages ...1A, Malat1 ...
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Clinicopathological and prognostic significance of long noncoding RNA MALAT1 in human cancers: a review and meta-analysis
... LncRNAs: long noncoding RNAs; MALAT1: the metastasis-associated lung adenocarcinoma transcript 1; qRT-PCR: quantitative real-time polymerase chain reaction; ISH: in situ hybridization; HWE: ...
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Long Noncoding RNA: Recent Updates in Atherosclerosis
... e.g. MALAT1 works as a decoy to trap and accumulate specific splicing factors in nuclear ...of MALAT1 results in homogeneous distribution of splicing factors in the nucleus thus inhibiting pre-mRNA ...
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Combination of long noncoding RNA <em>MALAT1</em> and carcinoembryonic antigen for the diagnosis of malignant pleural effusion caused by lung cancer
... for MALAT1, H19, CUDR, and CEA were ...of MALAT1 and CEA (AUC, ...baseline MALAT1 expression in pleural fluid was inversely correlated with chemotherapy response in patients with ...
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The Long Noncoding RNA HEAL Regulates HIV 1 Replication through Epigenetic Regulation of the HIV 1 Promoter
... (23). RNA interference (RNAi)-mediated silencing of an lncRNA, NRON, increased HIV-1 replication by stimulating NFAT (nuclear factor of activated T cells) and viral long terminal repeat (LTR) activities ...
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Original Article Glyoxalase 1, regulated by LncRNA MALAT1, promotes malignant development of esophageal squamous cell carcinoma
... that long noncoding RNA (lncRNA) MALAT1 promotes proliferation and metas- tasis of esophageal squamous cell carcinoma (ESCC), and that the following microarray chip screening of MALAT1 ...
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Long noncoding RNA expression profiles in sub lethal heat treated hepatoma carcinoma cells
... Total RNA was reverse-transcribed using a PrimeScript RT reagent Kit with gDNA Eraser (Perfect Real Time) (RR047A, TaKaRa, Dalian, China) with a GeneAmp PCR system 2700 (Applied Biosystems, ...
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The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications
... this RNA to be polyadenylated ...motif, MALAT1 has a distinct sequence or secondary structure that allows it to localize to specific foci known as paraspeckles ...speckles, MALAT1 complexes with ...
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Original Article Long non-coding RNA ANRIL promotes tumorigenesis in glioma via MAPK signaling pathways
... Abstract: Long non-coding RNA has been proven to be involved in many biological processes in cancer tumorigen- esis and progression. LncRNA ANRIL has various expression patterns in diverse human cancers. ...
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