The MAP kinase cascade
Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.
... Interaction between Ste5p and members of the MAP kinase cascade: The finding that Ste5p interacts with Stel l p , Ste7p and Fus3p suggests that one role of Ste5p in [r] ...
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The Ustilago maydis MAP kinase signaling pathway: Identification of MAP kinase targets by phospho-peptide enrichment
... the MAP kinases Kpp2 and Kpp6. To artificially induce MAP kinase signaling we used the strain FB1fuz7DD in which a constitutive active allele of the MAP kinase-kinase Fuz7 ...
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Quantitative Performance and Tradeoffs in the MAP Kinase Signaling Module
... the MAP kinase cascade Previous studies have identified many biologically-relevant quantitative features of MAP kinase pathways, including ultrasensitivity, bistability, and signal ...
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Role of a Mitogen-Activated Protein Kinase Cascade in Ion Flux-Mediated Turgor Regulation in Fungi
... complete MAP kinase cascade ...functional MAP kinase cascade, the turgor poise is lower and may be insufficient to maintain turgor when the mutants are subjected to high external ...
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MAP kinase phosphatases
... protein MAP kinases are key signal-transducing enzymes that are activated by a wide range of extracellular ...of MAP kinases by a phosphorylation cascade has long been recognized as significant, ...
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Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6
... instance, p38 α down-regulates its own activity by inducing expression of dual specificity phosphatase 1 (DUSP1), which de-phosphorylates and inactivates p38 and JNK [5,6]. p38 α also phosphorylates TAB1, leading to the ...
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Inhibition of MAP Kinase Kinase Prevents. Lipopolysaccharide-Stimulated Monocytes
... serine/threonine kinase Raf-1 ...dual-specificity MAP ki- nase kinases, MEK1 and MEK2, which phosphorylate ERKs on two critical tyrosine and threonine ...
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Oncogenic Activation of MAP Kinase by BRAF Pseudogene in Thyroid Tumors
... The high frequency of BRAF pseudogene expression in benign goiters suggests that it may play a role in initiating goiter formation or that a subset of goiters may contain precursor lesions such as BRAF pseudogene ...
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Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2
... Besides, MAP kinases, such as the downstream ROCK cascade molecule p38-MAPK, have a role in the develop- ment of cardiac hypertrophy, remodeling, and contrac- tile dysfunction (35 ...
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Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes
... protein kinase C (PKC), mitogen-activated protein kinases (MAPKs), and 90-kD ribosomal S6 kinase ...protein kinase cascade of phosphorylation by examining the time course of activation of ...
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Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
... Stimulating neutrophils with either LTB 4 or C5a resulted in a strong phosphorylation of ERK which was reduced following MKP-2 deletion. Work by Liu et al showed that ERK is a negative regulator of migration 32 and this ...
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Localization of ERK/MAP Kinase Is Regulated by the Alphaherpesvirus Tegument Protein Us2
... ERK/MAP kinase cascade is stimulated upon the binding of extracellular growth factors, such as epidermal growth factor, to their respective transmembrane tyrosine ki- nase ...
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Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
... Stimulating neutrophils with either LTB 4 or C5a resulted in a strong phosphorylation of ERK which was reduced following MKP-2 deletion. Work by Liu et al showed that ERK is a negative regulator of migration 32 and this ...
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Reciprocal Regulation of AKT and MAP Kinase Dictates Virus-Host Cell Fusion
... Raf/MEK/ERK cascade supports fusion through host cell cy- toskeletal rearrangement, AKT/PKB signaling acts as a host defense pathway which negatively regulates F protein-induced membrane fusion through ...
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Dominant Mutations of Drosophila MAP Kinase Kinase and Their Activities in Drosophila and Yeast MAP Kinase Cascades
... The subdomain VIB contains the catalytic loop and the aspartic acid at residue 206 would be the catalytic base that accepts the proton from the hydroxyl group of the s[r] ...
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Human Endotoxemia Activates p38 MAP Kinase and p42/44 MAP Kinase, But Not c-Jun N-terminal Kinase
... p42/p44 MAP Enzymatic Activity in Peripheral Blood Leukocytes To confirm that enhanced phosphorylation of MAPKs after in vivo LPS challenge is accompanied by en- hanced enzymatic activity of these enzymes, MAPKs ...
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The calcium/calmodulin regulated kinase cascade in learning and memory
... CaM kinase cascade 19 It is important to note that the distinction between STM and LTM derived from the latter studies differs from the neuropsychological concept described ...
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Association of p34cdc2 kinase and MAP kinase with microtubules during the meiotic maturation of Xenopus oocytes
... Int J Dc\" Hiu) JS 651 659 (1 yl) I ) 651 Association of p34cdc2 kinase and MAP kinase with microtubules during the meiotic maturation of Xenopus oocytes ARLETTE FELLOUS', MICHAEL KUBELKA', CATHERINE[.] ...
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The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence
... activated protein (MAP) kinase, Hog1. Interestingly, in vitro, Sch9p interacts with both Sko1p and Hog1p, and phosphorylates Sko1p. Hog1p is the main regulator of the high osmolarity glycerol response (HOG) ...
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Requirement for ERK MAP kinase in mouse preimplantation development
... ERK MAP kinase in mouse preimplantation development Momoko Maekawa 1, *, Takuya Yamamoto 1, *, Michiaki Kohno 2 , Masatoshi Takeichi 3 and Eisuke Nishida 1,† Preimplantation development is a crucial step ...
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