The Nuclear pore complex (NPC)
The nuclear pore complex
... © BioMed Central Ltd (Print ISSN 1465-6906; Online ISSN 1465-6914) The nuclear pore complex (NPC) forms the conduit for the exchange of information between the nucleus and cyto- plasm. NPC structures ...
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Inhibition of Nuclear Import and Alteration of Nuclear Pore Complex Composition by Rhinovirus
... of nuclear pore complex (NPC) components were examined in cells infected with rhinovirus type ...nonshuttling nuclear proteins, using multiple nuclear import pathways, accumulated in ...
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Elucidating the Mechanism of mRNA Export Regulation by the Nuclear Pore Complex
... the nuclear envelope, separating genetic information contained in the nucleus from the greater cell ...The nuclear pore complex (NPC) is nature’s largest protein channel, and it is the sole ...
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Differential Targeting of Nuclear Pore Complex Proteins in Poliovirus-Infected Cells
... two nuclear pore complex (NPC) proteins, Nup153 and ...125-MDa complex composed of multiple copies of 30 different ...of nuclear import and relocalization of host nuclear ...
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Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome
... than 50 monogenic causes of SRNS have been described, a large proportion of SRNS remains unexplained. Recently, it was discovered that mutations of NUP93 and NUP205, encoding 2 proteins of the inner ring subunit of the ...
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SUMOylation of the nuclear pore complex basket is involved in sensing cellular stresses
... The nuclear pore complex (NPC) is the major conduit for nucleocytoplasmic transport and serves as a platform for gene regulation and DNA ...in nuclear pore dynamics and ...yeast ...
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Misdelivery at the nuclear pore complex-stopping a virus dead in its tracks
... the nuclear pore complex-stopping a virus dead in its tracks Flatt, Justin W ; Greber, Urs F Abstract: Many viruses deliver their genomes into the host cell’s nucleus before they ...the ...
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Single molecule imaging to characterise the transport mechanism of the Nuclear Pore Complex
... Summary In the eukaryotic cell, a large macromolecular channel, known as the Nuclear Pore Complex (NPC), mediates all molecular transport between the nucleus and cytoplasm. In recent years, ...
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Importin β modulates the permeability of the nuclear pore complex in a Ran dependent manner
... Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States; 12 Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, United States Abstract Soluble ...
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Selective Removal of FG Repeat Domains from the Nuclear Pore Complex by Enterovirus 2Apro
... host nuclear RNA binding proteins for efficient ...in nuclear transport in enterovirus-infected cells that lead to the cytoplasmic accumulation of these ...the nuclear pore complex ...
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Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex
... The nuclear pore complex (NPC) is a protein assembly that contains several distinct ...hetero-oligomeric complex, that also contains Nup160, Nup133, Nup96, and the mammalian homolog of yeast ...
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Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection
... the nuclear pore complex (NPC), which regulates the passage of proteins, nucleic acids, and solutes through the nuclear envelope, require virus capsid uncoating before viral DNA can access the ...
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Kinesin-1-Mediated Capsid Disassembly and Disruption of the Nuclear Pore Complex Promote Virus Infection
... the nuclear pore complex (NPC), which regulates the passage of proteins, nucleic acids, and solutes through the nuclear envelope, require virus capsid uncoating before viral DNA can access the ...
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The two tempos of nuclear pore complex evolution: highly adapting proteins in an ancient frozen structure
... the nuclear pore complex (NPC), including all the identified nucleoporins, the components of their anchoring system and some of their main ...the nuclear pore structure, share homologs ...
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Localization of nucleoporin Tpr to the Nuclear Pore Complex is essential for Tpr mediated regulation of the export of unspliced RNA
... the nuclear pore complex (NPC) that localizes exclusively to intranuclear ...the nuclear phase of the NPC and plays a role in mitotic spindle checkpoint ...nucleopore complex is crucial ...
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BGLF4 Kinase Modulates the Structure and Transport Preference of the Nuclear Pore Complex To Facilitate Nuclear Import of Epstein-Barr Virus Lytic Proteins
... the nuclear import of importin  and canon- ical NLS-mediated nuclear transport ...the nuclear pore, Nup62 serves as a major barrier for molecular transport between the nucleus and ...for ...
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The Structure of the Nuclear Pore Complex (An Update)
... THE NUCLEAR PORE COMPLEX SYMMETRIC CORE Recent studies have reported near-atomic resolution architectures of the symmetric core for NPCs from humans, ...
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Mengovirus-Induced Rearrangement of the Nuclear Pore Complex: Hijacking Cellular Phosphorylation Machinery
... the nuclear pores appears to be primarily due to proteolytic degradation of some nucleoporins (protein components of the pore), whereas this effect in cardiovirus-infected cells is triggered by the leader ...
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The Oncogene eIF4E Reprograms the Nuclear Pore Complex to Promote mRNA Export and Oncogenic Transformation
... Lazaris-Karatzas, A., Montine, K.S., and Sonenberg, N. (1990). Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5 0 cap. Nature 345, 544–547. Noble, K.N., Tran, E.J., Alca´zar-Roma´n, ...
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Yeast Integral Membrane Proteins Apq12, Brl1, and Brr6 Form a Complex Important for Regulation of Membrane Homeostasis and Nuclear Pore Complex Biogenesis
... when nuclear pore complexes (NPCs) are constructed within the existing nuclear membrane, as occurs during in- terphase in all ...essential nuclear envelope/endoplasmic reticulum (NE/ER) ...
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