the programmed death ligand 1
<p>Use of Programmed Death Receptor-1 and/or Programmed Death Ligand 1 Inhibitors for the Treatment of Brain Metastasis of Lung Cancer</p>
... of programmed death receptor-1/programmed death ligand 1 (PD-1/PD-L1) can stimulate surrounding T cells and thus have antitumor effects in the ...PD- 1/PD-L1 ...
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Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors
... and programmed cell death 1 (PD-1)/ programmed death ligand-1 (PD-L1)—unleash tumor- specific immune responses and are now FDA-approved to treat melanoma, lung ...
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Programmed death-ligand 1 is upregulated in intrahepatic lymphoepithelioma-like cholangiocarcinoma
... Intrahepatic lymphoepithelioma-like cholangiocarcinoma (LELCC) is a rare variant of cholangiocarcinoma. Here, we report the largest single series of LELCC cases yet studied (n = 13). We retrospectively analyzed the ...
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The Expression of Programmed Death Ligand-1 within Stages of Oral Squamous Cell Carcinoma: Immunohistochemical Analysis
... (n=37). Programmed Death Ligand-1 positivity was observed in ...of Programmed Death Ligand-1 with stage II and IV ...of Programmed Death ...
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Upregulation of programmed death 1 on T cells and programmed death ligand 1 on monocytes in septic shock patients
... the programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) pathway by anti-PD-L1 antibody decreased apoptosis of human peripheral T cells from septic patients ...
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Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study
... factor 1 receptor (IGF-1R), or fibroblast growth factor receptor (FDFR) pathways in advanced disease, and no biomarkers have been established as predictors of survival or response to these agents ...
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Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma
... ing, 1 for weak staining, 2 for moderate staining, and 3 for strong ...scored 1, 26%–50% scored 2, 51%–75% scored 3, and 76%–100% scored 4 ...− 1) were used to determine the optimal cut-off score of ...
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Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)
... The presented crystal structures provide explanation for the molecular mechanism of dimerization of PD-L1 and the mechanism of inhibition of PD-L1/PD-1 interaction. The PD-L1 homodimer distantly resembles that of ...
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Intralymphatic histiocytosis in a patient with lung adenocarcinoma treated with pembrolizumab: a case report
... anti-programmed death (PD-1) antibody, has shown favorable antitumor efficacy in NSCLC patients [1, ...of programmed death ligand 1 (PD-L1) expression (tumor ...
5
A pooled analysis of the prognostic value of PD-L1 in melanoma: evidence from 1062 patients
... the programmed death-ligand 1 (PD-L1) and programmed death-1 (PD-1) axis ...identified ligand of PD-1 [15, ...
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Original Article PD-L1 blockade improves immune dysfunction of spleen dendritic cells and T-cells in zymosan-induced multiple organs dysfunction syndromes
... and programmed death ligand 1 (PD-L1) were expressed on T-cell, B-cell, DC and ...co-inhibitor, programmed death 1 (PD-1) was mainly expressed on the surface of ...
10
<p>Immunological nomograms predicting prognosis and guiding adjuvant chemotherapy in stage II colorectal cancer</p>
... PD-1, programmed cell death 1 protein; PD-L1, programmed death-ligand 1 protein; NGS, next-generation sequencing; TMA, tissue microarray; RFS, relapse-free ...
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<p>BTLA Expression in Stage I–III Non–Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes</p>
... stage. 1 The curative ability of traditional treatment — radiotherapy and chemotherapy — is limited, and it is not easily accepted by patients due to its high toxicity and adverse ...block programmed ...
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The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
... anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody has a good effect in the treatment of non-small cell lung cancer (NSCLC), but ...
6
CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment
... PD-1: Programmed cell death receptor-1; PD-L1: Programmed cell death ligand-1; NSCLC: Non- small-cell lung cancer; ADC: Adenocarcinoma; SCC: Squamous cell carci- ...
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The effect of chemotherapy on programmed cell death 1/ programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response
... in breast cancer cells, resulting in co-inhibitory signals activation [18]. Yang et al. [30] observed an increase of PD-L1 and PD-1 antigen expression in leukemia cells with decitabine treatment, and both PD-L1 ...
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Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma
... A total of 143 lung adenocarcinoma samples were collected from 84 females and 59 males. The mean age of the patients was 58.6 years, ranging from 36–79 years. Detailed clini- copathologic and molecular characteristics ...
7
Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives
... as programmed cell death 1 (PD-1), pro- grammed cell death 1 ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated antigen-4 (CTLA4), resulted in a significantly ...
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<p>Programmed cell death 1 expression and Epstein-Barr virus infection in chronic lymphocytic leukaemia: a prospective cohort study</p>
... of programmed cell death protein 1 (PD-1) and programmed cell death protein 1 ligand (PD-L1) on CD4+, CD8+, and CD19+ ...
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Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy
... cell death protein 1 (PD-1). PD-1 is expressed by T cells and interacts with its ligands programmed cell death protein ligand 1 (PD-L1) and programmed cell ...
7