tissue growth factor-β1
Original Article miR-183 inhibits connective tissue growth factor (CTGF) production in TGF-β1-treated keloid fibroblasts in vitro
... Abstract: CTGF plays a critical role in the development and progression of keloid (KL) fibrogenesis. However, the potential mechanisms of ECM deposition induced by overexpressing CTGF in keloid have not been completely ...
10
Growth factor Containing Hydrogels for Tissue Engineering Applications
... The physical and chemical instability of proteins are challenging issues in drug delivery [90]. Therefore, injectable protein pharmaceuticals are preferred over oral administration, because in the oral drug delivery ...
8
Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1
... In this study, we evaluated the effects pirfenidone on TGF-β1-mediated contraction of ECM and migration of lung fibroblasts isolated from patients with lung fibrosis toward fibronectin and compared them with those ...
14
The molecular basis of hypertrophic scars
... Transforming growth factor-β (TGF-β) plays a pivotal role in HTS formation TGF-β is one of the most im- portant growth factors that regulate tissue regeneration, cell differentiation, ...
12
Connective tissue growth factor antagonizes transforming growth factor ?1/Smad signalling in renal mesangial cells
... HMCs were serum-starved for 24 h followed by treatment with CTGF (25 ng/ml), TGF- β 1 (10 ng/ml) or both CTGF and TGF- β 1 together for the times indicated. Smad2 phosphorylation (P-Smad2) (A) and Smad3 phosphorylation ...
14
Original Article Genetic variations of the TNF-α -308 G>A promoter, and TGF-β1 T869C polymorphisms in Egyptian patients with rheumatoid arthritis
... necrosis factor-alpha (TNF-α), and transforming growth factor beta1 (TGF-β1) which have been found in RA; TNF-α is an anti-inflammatory cyto- kine which acts as permanent cytokine in ...
12
Fibroblast growth factor receptor splice variants are stable markers of oncogenic transforming growth factor β1 signaling in metastatic breast cancers
... patient-derived tissue samples, we verified the stable upregulation of FGFR1-β-IIIc that we initially identified in our in vitro TGF-β treatment and recovery microarray ...
15
Original Article Effect of transforming growth factor-β1 on the expression of peroxisome proliferator-activated receptor β and scar formation in rabbit ears
... PPAR-β, a nuclear receptor, plays a major role during the process of tissue injury and wound repair [13, 29, 30]. Recent study revealed that PPAR-β cooperated with TGF-β1 and partici- pated in wound healing ...
8
Effects of enamel matrix derivative and transforming growth factor-β1 on human osteoblastic cells
... Effect of EMD, TGF-b1 and the combination of both on osteoblastic cells proliferation was assessed by direct counting of cell number and BrdU incorporation into DNA. The BrdU is detecting in the tissue through ...
9
Rapamycin Inhibits Transforming Growth Factor β1 Induced Fibrogenesis in Primary Human Lung Fibroblasts
... transforming growth factor β1 (TGF-β1)-induced fibrogenesis in primary lung fibroblasts, and whether the effect of inhibition would occur through the mammalian target of rapamycin (mTOR) and ...
8
Increased expression of collagens, transforming growth factor β1, and β3 in gluteal muscle contracture
... As TGF-b1, -b2, and -b3 have a close relationship with the process of tissue fibrosis, we first examined the mRNA level in the contraction band by RT-PCR. The expression of TGF- b 1 and - b 3 was weakly detected ...
8
Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo
... transforming growth factor‑β1 (TGF‑β1), connective tissue growth factor (CTGF), α‑smooth muscle actin (α‑SMA), and type I colla‑ gen (COL‑1), which modulated the hepatic ...
10
Original Article Effects of rhBNP on myocardial fibrosis after myocardial infarction in rats
... (transforming growth factor) and CTGF (connective tissue growth factor) in 3 groups were analyzed using the RT-qPCR and western blotting analysis, ...
9
Spheroid formation of human thyroid cancer cells under simulated microgravity: a possible role of CTGF and CAV1
... Subconfluent monolayers of human follicular thyroid car- cinoma cells (FTC-133) were cultivated either on the RPM or on the CN and in parallel to the 1 g controls located in the same incubator, respectively. On both ...
11
Induction by transforming growth factor β1 of epithelial to mesenchymal transition is a rare event in vitro
... A549, Colo357, DU145, EpH4, H1299, HaCaT, HBL100, MCT, Panc-1, and 4T1 cells were maintained in Dulbecco’s modified Eagle’s medium (DMEM)/high-glucose medium (HyClone, Logan, UT, USA) supplemented with 10% fetal bovine ...
17
Enhanced expressions of neurodegeneration associated factors, UPS impairment, and excess Aβ accumulation in the hippocampus of mice with persistent cerebral toxocariasis
... some neurodegenerative diseases including AD [28]. In- creased TG2 was implied to enhance NFT formation and promote low-soluble complex formation, aggrega- tions of α-synuclein, and Aβ peptide cross-linking [29]. ...
14
Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion
... MenSC-secreted growth factors are involved in ovarian function recovery in mice ...that growth factors transmitted para- crine signals were important in MenSC-treated endomet- ...endometrial growth ...
12
The roles of endoglin gene in cerebrovascular diseases
... studies are consistent with the studies on skin AVM development, and support the notion that an injury (angiogenic stimulation) is needed to induce bAVM. Eng-deficient bAVM mouse models have been used to analyze the ...
12
Expression of epidermal growth factor, transforming growth factor-β1 and adiponectin in nipple aspirate fluid and plasma of pre and post-menopausal women
... NAF and plasma EGF, TGF-β1, and adiponectin were measured using ELISA based immunoassays (R&D Sys- tems, Minneapolis, MN, USA). Plasma samples were di- luted prior to the analysis according to the manufacturer ...
5
Enhancing intervertebral disc repair and regeneration through biology: platelet rich plasma as an alternative strategy
... especially growth factors, could effectively regulate the metabolic balance of the extracellular matrix and maintain the homeostasis of the interverte- bral disc ...and tissue engineer- ing based on stem ...
9