Tissue microenvironment
Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity
... Barrett tissue microenvironment and give an insight into how these processes could potentially support metaplastic pro- gression through the alteration of cellular energy ...
13
Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer
... tumour microenvironment promote tumour growth, vascular development and enable evasion of anti-tumour immune responses, by disabling infiltrating dendritic ...tumour microenvironment that directly influence ...
9
Transglutaminase 2 mediates the biomechanical properties of the colorectal cancer tissue microenvironment that contribute to disease progression
... on tissue sections taken from patients with CRC. The Tissue microarray (TMA) used has been described previously [29], along with clinical parameters matching the ...of tissue biopsies obtained in ...
18
Influence of the Tissue Microenvironment on Toll-Like Receptor Expression by CD11c+ Antigen-Presenting Cells Isolated from Mucosal Tissues
... mucosal tissue must be adapted to handle such ...different tissue sites have func- tional ...that tissue microenviron- ments impose a significant influence on the function of DCs and subsequent ...
9
Tumor suppressor ARF regulates tissue microenvironment and tumor growth through modulation of macrophage polarization
... Tumor microenvironment is constituted by a heterogeneous population of nonmalignant stromal cells that have critical roles in tumor progression and metastasis [1, ...tumor microenvironment, promoting the ...
16
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
... The malignancy of cancer is rooted in the ability of tumor cells to spread to distant locations in the body and to form metastases. The formation of metastases is a complex process involving multiple steps: first, tumor ...
8
Serum peptidome for cancer detection: spinning biologic trash into diagnostic gold
... highly abundant resident blood proteins such as albumin (12, 16, 19) (Figure 1). The concentration of any LMW analyte in the circulation is completely dependant on its production and clearance rates. Given the ability of ...
6
MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes
... MAP4K4 deficiency in T cells results in IL-6 overproduction. These IL-6-producing T cells infiltrate into adipose tissue. In adipose tissue microenvironment, IL-6 secreted from IL-6-prod[r] ...
6
Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles
... a Tissue Microenvironment Group, Division of Cancer &Genetics, School of Medicine, Heath Park, Cardiff University, Cardiff Wales, UK; b Département de microbiologie et immunologie, F[r] ...
6
Co evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance
... Invasion is the first observable step of cancer progres- sion. Cancer invasion occurs in a particular context of tissue microenvironment which is under constant evolu- tion largely due to the interactions ...
11
The impact of ultraviolet- and infrared-based laser microdissection technology on phosphoprotein detection in the laser microdissection-reverse phase protein array workflow
... the tissue microenvironment ...for tissue from multiple sections or slides to be collected into the same tube, minimizing potential for sample ...larger tissue sections or multiple ...
8
Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering
... growth, tissue repair and modeling [183, ...advantages, tissue-specific dECMs have been extracted from a variety of native tissues such as skeletal muscle, skin, urinary blad- der, small intestine, brain, ...
22
Conflicting Roles of Connexin43 in Tumor-Induced Inflammation and Cancer Pathology
... Reactive Astrocytes, Immune Cells, and Cx43 Expression in the Glioma Microenvironment 23.. The interaction between tumor cells and their microenvironment is implicated in modulating [r] ...
16
Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival
... tumor microenvironment, including a significant decrease in PMN-MDSCs ...inflammatory microenvironment induced by the blockade and could potentially limit the efficacy of the ...
22
<p>Esophageal Microenvironment: From Precursor Microenvironment to Premetastatic Niche</p>
... regulation of HIF-1 α on angiogenesis in esophageal tissues has been reported in the BE microenvironment. 13 In EC, HIF-1 α protein expression is also signi fi cantly correlated with VEGF protein expression and ...
23
Estrogenic microenvironment generated by organochlorine residues in adipose mammary tissue modulates biomarker expression in ERα positive breast carcinomas
... pose tissue adjacent to breast carcinoma is responsible for generating an estrogenic microenvironment that may influence the tumor biological ...adipose tissue were associ- ated with an increase in ...
9
Estrogenic microenvironment generated by organochlorine residues in adipose mammary tissue modulates biomarker expression in ERα-positive breast carcinomas
... DDT isomers and metabolites bind to and transcriptionally activate human ERα [29]. Moreover, organochlorine has been shown estrogenic in MCF-7 cells by the expression of PR [29]. Using a transgenic mouse model, Villa and ...
9
Analysis of PD-1 related immune transcriptional profile in different cancer types
... tumor microenvironment; ICB: immune checkpoint blockade; FDA: Food and Drug Administration; TCGA : The Cancer Genome Atlas; MCP: microenvironment cell populations; KEGG: Kyoto Encyclopedia of Genes and ...
11
Growth of Listeria monocytogenes within a Caramel Coated Apple Microenvironment
... Growth of Listeria monocytogenes within a Caramel Coated Apple Microenvironment Growth of Listeria monocytogenes within a Caramel Coated Apple Microenvironment Kathleen A Glass, Max C Golden, Brandon[.] ...
5
Tissue factor in tumor microenvironment: a systematic review
... anti-tumor immunity is abrogated primarily due to the dysfunction of cytotoxic T lymphocytes and NK cells and the accumulation of myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment [80]. As ...
8