tissue specificity
Organ specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA
... Among the major questions in developmental biology are how cells are specified to form distinct cell types and how tissue-specific programs of gene expression are established and maintained. Key players in this ...
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Mining tissue specificity, gene connectivity and disease association to reveal a set of genes that modify the action of disease causing genes
... Tissue specificity has subsequently been linked to a number of significant outcomes including level of expres- sion [3], ability to detect cis-acting and trans-acting expression- quantitative trait loci ...
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In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation.
... hepatic tissue required the combined action of both enhancers I and II, whereas the proximity of these two enhancers was insufficient to confer tissue specificity on Xp ...
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Absence of Internal Ribosome Entry Site-Mediated Tissue Specificity in the Translation of a Bicistronic Transgene
... In recent years, expression vectors containing picornavirus IRESs have become popular. The advantages of IRES se- quences in gene targeting and generation of polycistronic tran- scripts are indisputable (29). However, ...
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Computational prediction of lncRNA-mRNA interactions by integrating tissue specificity in human transcriptome
... the tissue specificity of human ...of tissue-specific lncRNAs upregulating the expression level of their interacting tar- get mRNAs, the lncRNAs and mRNAs sharing the same tissue specificities ...
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Predicting Potential Drugs for Breast Cancer based on miRNA and Tissue Specificity
... of tissue- and cell lineage-specific ...and tissue specificity. Therefore, based on miRNA data and the tissue specificity of diseases, we propose a new method named as miTS to predict ...
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Nutritional regulation and tissue specificity of gene expression for proteins involved in hepatic glucose metabolism in rainbow trout (Oncorhynchus mykiss)
... 5. Tissue specificity of 6-phosphofructo-2-kinase/ fructose-2,6-biphosphatase (6PF-2K/F-2,6BPase), pyruvate kinase (PK), fructose-1,6-bisphosphatase (FBPase) and glucose transporter type 2 (Glut2) gene ...
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Selective estrogen receptor modulators: tissue specificity and clinical utility
... SeRM tissue specificity depends on numerous factors: 1) SERMs have differential and specific affinity for ER subtypes; 2) ER subtypes are differentially expressed in target tissues and can be ...
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The Autosomal Chorion Locus of the Medfly Ceratitis capitata. I. Conserved Synteny, Amplification and Tissue Specificity but Sequence Divergence and Altered Temporal Regulation
... Despite considerable sequence diversifica- tion, this locus has remained highly conserved in orga- nization throughout the genus: the same four chorion genes are found in all [r] ...
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Characterization of Bucolome N Glucuronide Formation: Tissue Specificity and Identification of Rat UDP Glucuronosyltransferase Isoform (s)
... Bucolome N-glucuronide (BCP-NG, main metabolite of bucolome (BCP) is the first N-glucuronide of barbituric acid derivatives isolated from rat bile. The objective of this study was to identify the main tissue ...
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Tissue specificity of cytosolic `K^+` retention, `Na^+` extrusion, and vacuolar `Na^+` sequestration traits in the context of differential salinity stress tolerance in barley and wheat
... Salinity stress tolerance is a physiologically complex trait that is conferred by the large array of interacting mechanisms. Among these, vacuolar Na + sequestration has always been considered as one of the key ...
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Tissue Specificity of the Kaposi's Sarcoma-Associated Herpesvirus Latent Nuclear Antigen (LANA/orf73) Promoter in Transgenic Mice
... Of the major organs, only the kidney and, to a lesser degree, the liver showed appreciable transgene expression by whole- mount analysis. Other organs (brain and skin) either were consistently negative in every animal we ...
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Translational contributions to tissue specificity in rhythmic and constitutive gene expression
... v2.0.11) in order to estimate expressed transcript models in each organ (using Cufflinks v2.2.1 [38]). Transcriptome- mapping reads in the sequential alignment were counted towards their location into the 5′ UTR, CDS or ...
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Too much data, but little inter-changeability: a lesson learned from mining public data on tissue specificity of gene expression
... the tissue distribution of gene expression across two major plat- forms, SAGE and microarray, where the high throughput data were recently ...with tissue samples from normal physio- logical states using the ...
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JC virus and simian virus 40 enhancers and transforming proteins: role in determining tissue specificity and pathogenicity in transgenic mice.
... The occurrence in JCSV40 and JCV transgenic mice of identical neural pathologies such as hypomyelination of the CNS, adrenal medulla neuroblastoma, and myenteric plexus tumors and the fa[r] ...
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Tissue specificity of lipid peroxidation under emotional stress in rats
... При социаль ной изоляции животных и нарушении цирка дианного ритма, показателем оксидативного стресса является снижение активности анти оксидантных энзимов – СОД и каталазы, как в п[r] ...
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A comprehensive functional analysis of tissue specificity of human gene expression
... generated tissue-specific networks for nine tissues using the Analyze Networks (AN) network algorithm in ...The tissue- specific networks for liver and adrenal gland are shown in Figure ...patterns ...
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Species and tissue specificity of prokinetic, laxative and spasmodic effects of Fumaria parviflora
... and/or tissue-selective effects of plant extracts have also been reported in earlier studies ...and/or tissue specific behavior of some plant materials is not ...
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Tissue specificity of antioxidant system functioning and lipid peroxidation in different age groups of amur carp
... Key features of tissue enzymes functioning in antioxidant system (AOS) in sexually mature and immature individuals of Amur carp were studied. The activity of antioxidant enzymes was highest in the myocardium and ...
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IDENTIFICATION OF AN R-LOCUS REGION THAT CONTROLS THE TISSUE SPECIFICITY OF ANTHOCYANIN FORMATION IN MAIZE
... Therefore, R can be considered as a regulatory locus determining the tissue-specific synthesis of UFGT (and, con- ceivably, of other anthocyanin biosynthetic enzymes.) A p[r] ...
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