TOP2A Gene
TOP2A as marker of response to pegylated lyposomal doxorubicin (PLD) in epithelial ovarian cancers
... TOP2A gene is located on the locus q21 of chromo- some 17, close to the HER2 gene, and is responsible for coding the nuclear enzyme type 2 topoisomerase alpha (TOP2A) ...[15]. TOP2A ...
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Original Article TOP2A expression predicts an unfavourable prognosis in neuroblastic tumors
... of TOP2A presented shorter biochemical recurrence-free survival (BRFS), and TOP2A was an indepen- dent prognostic factor of BRFS in this ...nuclear TOP2A protein had a marked decreased OS [23, 24]. ...
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HER2 and TOP2A in high risk early breast cancer patients treated with adjuvant epirubicin based dose dense sequential chemotherapy
... of TOP2A in cell proliferation (reviewed in [12,58]), we observed strong associations of the proliferation marker Ki67 and tumor grade (which is characterized by Ki67 labelling) with TopoIIa protein and ...
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Allelic imbalance at the HER2/TOP2A locus in breast cancer
... that TOP2A coam- plification is the biological rationale behind these obser- vations ...The TOP2A gene encodes topoisomerase II alpha, a 170 kDa enzyme that catalyzes the topological DNA changes ...
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A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy
... the TOP2A index, as the protein product of the TOP2A gene is directly involved in DNA ...the TOP2A index to predict response in the docetaxel-only treated ...the TOP2A index to predict ...
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Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer
... of TOP2A and TLE3, our findings were encouraging, although the results only approached statis- tical ...of TOP2A and TLE3 with the reduction in tumor volume after chemotherapy and the disease-free ...as ...
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Positive response to neoadjuvant cyclophosphamide and doxorubicin in topoisomerase II nonamplified/HER2/neu negative/polysomy 17 absent breast cancer patients
... Methods: We identified neoadjuvant DOX/cyclophosphamide treated breast cancer patients in our registry from 1997 to 2008 with sufficient tissue for testing (n = 34). Fluorescence in situ hybridization (FISH) testing was ...
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Original Article TOP2A is an independent prognostic factor in patients with operable invasive breast cancer: a large-scale study
... and TOP2A gene co-amplifi- cationexhibit greater benefit from an anthracy- cline-based regimen than from trastuzumab ...for TOP2A gene status/protein expression detected by FISH, qPCR or IHC ...
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Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer
... against TOP2A (clone SWT3D1; DAKO, Carpenteria, CA, USA) at dilution 1:800 and Flex Plus detection system in autostainer 48Ultra ...using TOP2A (17q21)/ CEP17 probe kit (Kreateck Biotechnology, San Diego, ...
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Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a / mutants
... zebrafish top2a gene results in the expression of non-functional Top2a protein post MZT in blm ...of top2a, and not top2b which is negligible ...maternal top2a transcript and ...
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Original Article Over-expression of TOP2A as a prognostic biomarker in patients with glioma
... of TOP2A and its clinical significance in ...that TOP2A is highly expressed in glioma tissues compared with corresponding normal ...that TOP2A over expression was highly correlated with grade stage, ...
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Towards gene network estimation with structure learning
... complex. Gene interactions are studied through gene network. Gene network is a group of coordinately expressed genes controlling a particular function of an ...reconstructing gene networks, we ...
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Human Serum Paraoxonase (PON-1) and hemochromatosis gene (HFE) gene polymorphisms in occupationally exposed lead workers from Saudi Arabia
... 2007). Gene polymorphisms in the PON1 and HFE genes were evaluated using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism ...
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Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF)
... FLT3 gene are found in many AML subtypes and are considered class I mutations con- ferring a proliferation and/or survival advantage of the leukemic blasts ...
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From pattern to gene, from gene to pattern
... pair-rule gene mutants in Drosophila was wholly unexpected because it revealed that the establishment of the overt segmental periodicity of the larva proceeded through an intermediate, morphologically invis- ible, ...
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Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer
... In conclusion, our data showed that MH treatment was superior in inducing thermal stress in comparison to EH. MH exposure triggers cell death more aggressively (increased cell necrosis) and is more efficient in producing ...
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Quantum dot-based immunofluorescent imaging and quantitative detection of TOP2A and prognostic value in triple-negative breast cancer
... the TOP2A and major clinical pathological parameters (such as age, tumor size, tumor grade, and lymph node status) was assessed using the Mann– Whitney U-test or Kruskal–Wallis ...of TOP2A for ...
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Dynamics and Heterogeneity of Gene Expression and Epigenetic Regulation at the Single-Cell Level
... In Chapter 3, we investigated the response of target gene expression to direct recruitment and de-recruitment of four different CRs. Remarkably, all four CRs demonstrated similar all-or-none event profiles during ...
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Isolation and Characterization Of Novel Egyptian Regulatory Gene Tri 10 From Fusarium fujikuroi (MG211161)
... 10 gene (MG674224) with of Gibberella pulicaris ...10) gene, complete cds, Fusarium sporotrichioides ...trichothecene gene and Fusarium sp ...our gene sharing 70 % identity of the consensus ...
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Update on the olfactory receptor (OR) gene superfamily
... This dynamic flexibility is also reflected among individual humans; examining 51 candidate OR genes on DNA chips in 189 ethnically diverse sub- jects, a striking amount of population diversity was found. 14 Segregating ...
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