Trans-Golgi network (TGN)
Herpes Simplex Virus Type 1 Capsids Transit by the trans-Golgi Network, Where Viral Glycoproteins Accumulate Independently of Capsid Egress
... the trans-Golgi network (TGN) is often cited as a potential site of reenvelopment, other organelles have also been proposed, including the Golgi, endoplasmic reticulum- Golgi ...
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African Swine Fever Virus Causes Microtubule-Dependent Dispersal of the trans-Golgi Network and Slows Delivery of Membrane Protein to the Plasma Membrane
... Viral interference with secretory cargo is a common mechanism for pathogen immune evasion. Selective down regulation of critical immune system molecules such as major histocompatibility complex (MHC) proteins enables ...
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Envelopment of Human Cytomegalovirus Occurs by Budding into Golgi-Derived Vacuole Compartments Positive for gB, Rab 3, Trans-Golgi Network 46, and Mannosidase II
... the Golgi resident enzyme mannosidase II, the Golgi marker TGN (trans-Golgi network) 46, and the secretory vacuole marker Rab 3 in all cell types ...a Golgi-derived secretory ...
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Dimerization of the vacuolar receptors AtRMR1 and-2 from Arabidopsis thaliana contributes to their localization in the trans-Golgi Network
... Abstract: In Arabidopsis thaliana, different types of vacuolar receptors were discovered. The AtVSR (Vacuolar Sorting Receptor) receptors are well known to be involved in the traffic to lytic vacuole (LV), while few ...
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Phosphorylation by the Varicella-Zoster Virus ORF47 Protein Serine Kinase Determines whether Endocytosed Viral gE Traffics to the trans-Golgi Network or Recycles to the Cell Membrane
... Like all alphaherpesviruses, varicella-zoster virus (VZV) infection proceeds by both cell-cell spread and virion production. Virions are enveloped within vacuoles located near the trans-Golgi network ...
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The trans Golgi Network Is Lost from Cells Infected with African Swine Fever Virus
... The cellular secretory pathway is important during the assembly and envelopment of viruses and also controls the transport of host proteins, such as cytokines and major histocompatibility proteins, that function during ...
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Mycovirus Cryphonectria Hypovirus 1 Elements Cofractionate with trans-Golgi Network Membranes of the Fungal Host Cryphonectria parasitica
... secretory trans-Golgi network (TGN) and in endo- somes (48), was obtained from cDNA prepared from RNA obtained as previously described (60), using primers designed based on the Neurospora crassa ...
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Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication
... It has recently been proposed that the herpes simplex virus (HSV) protein ICP0 has cytoplasmic roles in blocking antiviral sig- naling and in promoting viral replication in addition to its well-known proteasome-dependent ...
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A trans-Golgi Network Resident Protein, golgin-97, Accumulates in Viral Factories and Incorporates into Virions during Poxvirus Infection
... Poxviruses are large enveloped double-stranded DNA vi- ruses with a complex morphology. Vaccinia virus (VV), the most extensively studied member of the Poxviridae, possesses a genome of approximately 192 kbp in size that ...
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Redistribution of Cellular and Herpes Simplex Virus Proteins from the Trans-Golgi Network to Cell Junctions without Enveloped Capsids
... Herpes simplex virus (HSV) and other alphaherpesviruses assemble enveloped virions in the trans-Golgi network (TGN) or endosomes. Enveloped particles are formed when capsids bud into TGN/endosomes ...
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Env7p Associates with the Golgin Protein Imh1 at the trans-Golgi Network in Candida albicans
... ABSTRACT Vesicular dynamics is one of the very important aspects of cellular physiology, an imbalance of which leads to the disorders or diseases in higher eu- karyotes. We report the functional characterization of a ...
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GPI biosynthesis is essential for rhodopsin sorting at the trans Golgi network in Drosophila photoreceptors
... Rhodopsin 1 (Rh1), the rhodopsin expressed in R1-R6 cells, the major retinal photoreceptor cells, is the most accessible protein for investigating apical polarized transport in fly photoreceptors. This is because it is ...
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Herpes Simplex Virus Type 1 Glycoprotein K and the UL20 Protein Are Interdependent for Intracellular Trafficking and trans-Golgi Network Localization
... Final envelopment of the cytoplasmic herpes simplex virus type 1 (HSV-1) nucleocapsid is thought to occur by budding into trans-Golgi network (TGN)-derived membranes. The highly membrane-associated ...
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Traffic Through the Trans-Golgi Network and the Endosomal System Requires Collaboration Between Exomer and Clathrin Adaptors in Fission Yeast
... the trans-Golgi network (TGN) and early endosomes (EEs), and contribute to the retention of some proteins, including the Saccharomyces cerevisiae chitin synthase Chs3 and murine mannose-6-phosphate ...
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Essential Role Played by the C-Terminal Domain of Glycoprotein I in Envelopment of Varicella-Zoster Virus in the trans-Golgi Network: Interactions of Glycoproteins with Tegument
... trans-Golgi network (TGN) (10, 30). An analogous mechanism has been postulated to be involved in the envelopment of pseudorabies virus (33). The glycoproteins of VZV are tar- geted to the TGN and, in ...
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Identification of a Role for the trans-Golgi Network in Human Papillomavirus 16 Pseudovirus Infection
... Human papillomavirus 16 (HPV16) enters its host cells by a process that most closely resembles macropinocytosis. Uncoating occurs during passage through the endosomal compartment, and the low pH encountered in this ...
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A GFP tagged version of the pseudorabies virus protein UL56 localizes to the Golgi and trans Golgi network through a predicted C terminal leucine rich helix in transfected cells
... the Golgi compartment localization of pUL56, we constructed a plasmid expressing GFP- Rab6a, a small GTPase, which is a ubiquitous rab as- sociated with membranes of the Golgi complex as well as that of ...
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Syntaxin 5-Dependent Retrograde Transport to the trans-Golgi Network Is Required for Adeno-Associated Virus Transduction
... the Golgi apparatus and that Golgi apparatus disruption caused by the drug brefeldin A efficiently blocks AAV serotype 2 (AAV2) ...the Golgi apparatus for AAV transduction remains to be established ...
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Herpes Simplex Virus gE/gI Must Accumulate in the trans-Golgi Network at Early Times and Then Redistribute to Cell Junctions To Promote Cell-Cell Spread
... the trans-Golgi network (TGN) in HSV-infected cells at early times of infection and when gE/gI is expressed by transfection or with virus vectors (1, 13, 30, ...is trans- ported specifically ...
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Suppression of Tetherin-Restricting Activity upon Human Immunodeficiency Virus Type 1 Particle Release Correlates with Localization of Vpu in the trans-Golgi Network
... Vpu promotes the efficient release of human immunodeficiency virus type 1 (HIV-1) by overcoming the activity of tetherin, a host cell restriction factor that retains assembled virions at the cell surface. In this study, ...
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