transforming growth factor beta (TGFβ)
Coordinate regulation of transforming growth factor beta gene expression and cell proliferation in hamster lungs undergoing bleomycin induced pulmonary fibrosis
... The number of mesenchymal cells, as well as their ability to synthesize extracellular matrix (ECM) components, greatly increase in the interstitium of fibrotic lungs. We have previously shown that the transcription of ...
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Recombinant latent transforming growth factor beta 1 has a longer plasma half life in rats than active transforming growth factor beta 1, and a different tissue distribution
... Transforming growth factor beta 1 (TGF-beta 1) is a key regulator of cell growth and differentiation. Under normal physiological conditions, it is made as a biologically latent ...
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Cellular distribution of transforming growth factor beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride induced rat liver fibrosis
... from transforming growth factor-beta 1 (TGF-beta 1) and procollagen alpha 1(I), alpha 1(III), and alpha 1(IV) genes were studied in carbon tetrachloride (CCl4)-induced rat liver ...
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Developmental tumours, early differentiation and the transforming growth factor beta superfamily
... toderm where, probably under influence of hormones such as PTHrP (van de Stolpe et al., 1993; see also Verheijen and Defize, this issue), they differentiate into parietal endoderm (PE). They eventually line the entire ...
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Regulation of transforming growth factor beta (TGFβ) at the level of nuclear entry
... Examination of TGFβR1 in the absence of TGFβR2 presents a more difficult problem. TGFβR1 alone does not bind ligand with strong affinity and its activation requires direct phosphorylation by TGFβR2 (Attisano 1998, Shi Y ...
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Transforming growth factor beta in disease: the dark side of tissue repair
... Two of the proteoglycans induced by TGF-fl in the glomerulonephritis model, decorin and biglycan, are inhibitors of TGF-f 28; their elevated expression under the influence of TGF-f may b[r] ...
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Transforming growth factor beta and breast cancer: Tumor promoting effects of transforming growth factor β
... lial growth factor, facilitation of basic fibroblast growth factor mediated capillary sprouting, inhibition of endothe- lial cell migration, and increased production of extracellular matrix, ...
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Investigating the Role of Retinoblastoma Protein and Transforming Growth Factor-Beta in Growth Inhibition
... To examine our proposed models, we can use shRNAs against DNMT1 and MBD2 to knockdown their expression and examine whether depletion of these proteins compromise TGF-β mediated growth arrest. In addition, we can ...
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Lysyl oxidase regulates transforming growth factor-[beta]1 function in bone
... In bone, a specific spatial relationship between the two predominant components, collagen fibrils and mineral, is critical for the mechanical function (286, 287), and the collagen fibrils apparently regulate the manner ...
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Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta
... The present study enlightens a mechanism of feedback loop controlling TGF b responses in human OA chon- drocytes. Contrary to previous studies, which examined one particular gene, we investigated the TGFb-induced ...
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Influenza virus neuraminidase activates latent transforming growth factor beta.
... Transforming growth factor b (TGF- b ) is a family of proteins secreted by virtually all cells in a biologically inactive form. TGF- b levels increase during many pathophysiological situations, ...
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Transforming growth factor-β1 gene polymorphism in psoriasis vulgaris
... The authors did not find a significant difference between psoriasis patients and controls in the two codons, ie, TGF- β 1 gene polymorphism in codon 10 and 25 are not associated with [r] ...
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Transforming growth factor beta activation in irradiated murine mammary gland
... TGF- beta 1 in tumor xenografts overproducing active TGF-beta 1, without cross-reactivity in tumors expressing similar levels of latent TGF-beta ...TGF- beta 1 increased significantly within 1 ...
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Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals
... TGF beta 1 suppressed the evolution of arthritis even when administration was begun after the acute phase of the ...TGF beta 1 treatment greatly reduced inflammatory cell infiltration, pannus formation, and ...
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Transforming growth factor-beta receptor signalling is modulated by integrin-linked kinase
... which was also the best thing anyone could do for me. I would like to thank Brad Jackson and Michelle Im for making the lab fun, since I was almost always in such a gloomy and sassy mood towards the end. I would also ...
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Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases.
... regulatory factor with multiple functions, TGF-b1 participates in several important pathophysiological processes, and is currently studied ...tissue growth factor (CTGF) and TGF-b1 levels in hepatic ...
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and vascular endothelial growth factor in filtering bleb after trabeculectomy
... of Transforming growth factor beta-2 (TGF-β 2 ) and Vascular endothelial growth factor (VEGF) in filtering bleb tissues after trabeculectomy on rabbit eyes, and to discuss their ...
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Effects of Non-Collagenous Proteins, TGF-β1, and PDGF-BB on Viability and Proliferation of Dental Pulp Stem Cells
... of growth factors such as platelet-derived growth factor BB (PDGF-BB), transforming growth factor beta 1 (TGF-β1) and other bio-active molecules, sequestered during ...
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Expression of epidermal growth factor, transforming growth factor-β1 and adiponectin in nipple aspirate fluid and plasma of pre and post-menopausal women
... epidermal growth factor (EGF), transforming growth factor-beta 1 (TGF- β 1), and adiponectin and evaluated menopausal status and body mass index (BMI) as potential modifying ...
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Lack of transforming growth factor β signaling promotes collective cancer cell invasion through tumor stromal crosstalk
... Transforming growth factor beta (TGF- b ) is a pleiotro- pic cytokine that regulates growth arrest, cell motility, development, and differentiation ...II transforming ...
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