transient receptor potential vanilloid 4
Hypothermia increases aquaporin 4 (AQP4) plasma membrane abundance in human primary cortical astrocytes via a calcium/ transient receptor potential vanilloid 4 (TRPV4) and calmodulin mediated mechanism
... stretch-activated transient receptor potential vanilloid 4 calcium channel (TRPV4) is known to be essential in cell volume regulation: a TRPV4-mediated increase in Ca 2+ influx has been ...
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THE ROLE OF TRANSIENT RECEPTOR POTENTIAL VANILLOID 1 RECEPTOR IN DESIPRAMINE INDUCED ANALGESIC EFFECT IN DIABETIC MICE
... Mice of group I were administered normal saline solution to serve as a non-diabetic group. Desipramine, capsaicin and capsazepine were administered to their respected groups, daily for 8 days, starting on day 3 after STZ ...
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Transient Receptor Potential Vanilloid 1 Immunoreactive Innervation Increases in Fractured Rat Femur
... bone loss in mice and histomorphometric analysis shows inhibitory effects on indices of bone resorption and bone formation. In the current study, we focused on the relation- ship between pain and bone fracture, but there ...
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Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes
... Briefly, P2 chondrocytes were grown in DMEM on autoclaved coverslips at a density of 3 × 10 5 cells/mL. They were then fixed in ice-cold methanol for 10 min, washed and permeabilized with PBS-T and blocked with 10% BSA ...
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Forsythoside A exerts antipyretic effect on yeast-induced pyrexia mice via inhibiting transient receptor potential vanilloid 1 function
... corresponded serum for 1 h at room temperature. Then the sections were incubated with different primary antibodies: p-ERK (1:100, Cell Signaling Technology, USA), p-JNK (1:100, Cell Signaling Technology, USA) and ...
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Transient receptor potential Vanilloid 1 (TRPV1) in haematological malignancies
... Biosciences, San Jose, USA) for 10 min in the dark at room temperature. Cells were centrifuged at 350 x g for 5 min, then washed in 3 mL PBSA (PBS, 10% FBS, 0.1% sodium azide) and re-centrifuged for a further 3 min. ...
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Preventive Effect of SA13353, a Novel Transient Receptor Potential Vanilloid 1 Agonist, on Ischemia/Reperfusion Induced Renal Injury in Rats
... To support identifying the target molecules of SA13353, we measured plasma concentrations of SA13353 in rats. Blood samples were collected at 0.25, 0.5, 1, 2, 4 and 24 h from the cervical vein, with syringes ...
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Post-transcriptional regulation of 5’-untranslated regions of human Transient Receptor Potential Vanilloid type-1 (TRPV-1) channels: role in the survival of glioma patients
... (Table 3A). In fact, the TRPV1 v3 was found to be the only TRPV1 5’UTR transcript expressed in the majority (n = 38/44) of GBM samples (Table 3A). Moreover, we found that the GBM samples showed different TRPV1 v3 ...
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A Novel Mechanism for Calmodulin Dependent Inactivation of Transient Receptor Potential Vanilloid 6
... the Transient Receptor Potential (TRP) ‡ superfamily of twentyA seven ion channels are divided into six subAgroups (TRPC; TRPV; TRPM; TRPP; TRPA; ...TRPV1 4 , TRPV2 5 , TRPV5 6 and TRPA1 7 by ...
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Paeoniflorin protects diabetic mice against myocardial ischemic injury via the transient receptor potential vanilloid 1/calcitonin gene-related peptide pathway
... Fig. 2 TRPV1 gene knockout partially abrogates paeoniflorin (PF)-mediated cardioprotection against MI. a TRPV1 knockout attenuated the decrease in myocardial infarct size by PF treatment, the black arrow indicates the ...
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Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics
... a transient, rather than the normally sustained, membrane depolarisation in response to bright light, hence the name transient receptor potential (Minke et ...TRP vanilloid (TRPV), TRP ...
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TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL: AN EMERGING TARGET FOR PAIN
... the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious stimuli and transduce a diverse range of physical and chemical energy into action potentials in ...
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Influence of 1α, 25 dihydroxyvitamin D3 [1, 25(OH)2D3] on the expression of Sox 9 and the transient receptor potential vanilloid 5/6 ion channels in equine articular chondrocytes
... Total cellular protein lysate was isolated using radio- immunopreceptation assay (RIPA) buffer (150 mM NaCl, 50 mM Tris? HCl, pH 7.5, 5 mM ethylene glycol tetraace- tic acid (EGTA), 1% Triton, 0.5% sodium deoxycholate ...
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Capsazepine, a Transient Receptor Potential Vanilloid Type 1 (TRPV1) Antagonist, Attenuates Antinociceptive Effect of CB1 Receptor agonist, WIN55,212-2, in the Rat Nucleus Cuneiformis
... The nociceptive threshold was measured by the tail- flick apparatus (Harvard, USA). Tail-flick latency (TFL) was measured by exposing the dorsal surface of the rat’s tail (3, 5 and 7 cm from the caudal tip of the tail) ...
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Polymodal roles of transient receptor potential channels in the control of ocular function
... aberrant transient rather than sustained retinal membrane depolarization ...capsaicin receptor since this red pepper extract con- stituent is an agonist of this ...TRP vanilloid 1 ...mechano- ...
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Reduced transient receptor potential vanilloid 2 expression in alveolar macrophages causes COPD in mice through impaired phagocytic activity
... = 4 – 6 per group) of fold change of luminescence intensity with (w) FITC-dextran ...= 4 – 6 per group) of fold change of luminescence intensity with (w) FITC-dextran ...
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Implication of AMP-Activated Protein Kinase in Transient Receptor Potential Vanilloid Type 1-Mediated Activation of Endothelial Nitric Oxide Synthase
... at 4 months old received evodi- amine (10 mg/kg body weight) and ve- hicle by daily oral administration with gastric gavage for 4 wks (n = 10, each ...
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Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathways
... Mice included in the groups for urodynamic evaluation of the urinary bladder function (awake cystometry) underwent survival surgical procedure for catheter inser- tion. An animal was anesthetized with isoflurane (VEDCO, ...
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Transient receptor potential Vanilloid 1 (TRPV1) in haematological malignancies
... Expression of TRPV1 in leukocytes obtained from patients with a range of haematological malignancies, including multiple myeloma (MM) and B-cell non- Hodgkin’s Lymphoma (B-NHL), was then investigated (Chapter 6). TRPV1 ...
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Implication of Transient Receptor Potential Vanilloid Type 1 in 14,15-Epoxyeicosatrienoic Acid-induced Angiogenesis
... 5]. Recently, growing evidence suggests that TRPV1 is expressed in ECs and plays an important role in reg- ulating vascular tone and EC functions [6-8]. This TRPV1 function is particularly important because ECs may be ...
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