Translation Initiation Factor
Genetic Interactions of Yeast Eukaryotic Translation Initiation Factor 5A (eIF5A) Reveal Connections to Poly(A)-Binding Protein and Protein Kinase C Signaling
... tles between the nucleus and the cytoplasm, is required for mRNA Posas, F., M. Takekawa and H. Saito, 1998 Signal transduction by 3 ⬘ -end formation in yeast. Genes Dev. 11: 2545–2556. MAP kinases in budding yeast. Curr. ...
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Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC
... Eukaryotic translation initiation factor 4 gamma 1(EIF4G1) is related to tumorigenesis and tumor progression. However, its role and the underlying mechanisms in the regulation of tumor development in ...
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PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes
... eIF3 is the most complex translation initiation factor and plays at least two important roles in protein synthesis. First, eIF3 binds to the 40S ribosome and facilitates load- ing of the ...
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Original Article Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia
... eukaryotic translation initiation factor 3 subunit B; AML, acute myeloid leukemia; Sh-EIF3B, eukaryotic translation initiation factor 3 subunit B short hairpin RNA plasmids and ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... Eukaryotic translation initiation factor 2 (eIF2) is a G protein heterotrimer required for GTP-dependent delivery of initiator tRNA to the ...exchange factor for eIF2, is a heteropen- tamer ...
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Activation of AP-1-Dependent Transcription by a Truncated Translation Initiation Factor
... tion initiation factor, ...multisubunit translation initiation factor eIF3, a view supported here by our TAP-tagging data ...the translation of mRNAs transcribed in a pap1-depen- ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... ~2.7 × 10 6 clones screened, 8 positive clones were iso- lated using the most stringent reporter selection. To ret- est protein-protein interaction in yeast, library plasmids were rescued and cotransformed into the AH109 ...
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Influenza A Virus-Induced Degradation of Eukaryotic Translation Initiation Factor 4B Contributes to Viral Replication by Suppressing IFITM3 Protein Expression
... cellular translation machinery and its role during the viral infection have come into the focus of interest ...the translation of host mRNAs, thereby suppressing host innate defenses ...eukaryotic ...
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The Biological Roles of Translation Initiation Factor 3b
... protein translation level increases [31]; and (2) the translation initiation factor complex regulates the translation of many specific mRNAs involved in many significant cellular ...
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The IE180 Protein of Pseudorabies Virus Suppresses Phosphorylation of Translation Initiation Factor eIF2α
... We have previously shown that the porcine alphaherpesvirus pseudorabies virus (PRV) efficiently interferes with phosphoryla- tion of the eukaryotic translation initiation factor eIF2 ␣ . Inhibition ...
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Eukaryotic translation initiation factor 3 subunit G (EI F3G) resensitized HC T116/5-Fu to 5-fluorouracil (5-Fu) via inhibition of MRP and MDR1
... mortality factor for patients due to no available therapeutic ...eukaryotic translation initiation factor 3 subunit G (EIF3G) resensitized 5-Fu-resistant human CRC cells (HCT116/5-Fu) to ...
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Interaction of Translation Initiation Factor eIF4B with the Poliovirus Internal Ribosome Entry Site
... Poliovirus translation is initiated at the internal ribosome entry site ...standard initiation factors, this highly structured cis element in the 5 ⴕ noncoding region of the viral RNA guides the ribosome to ...
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The S. pombe Translation Initiation Factor eIF4G Is Sumoylated and Associates with the SUMO Protease Ulp2
... of translation factors, required for both the initiation and elongation steps of protein synthesis, have been identified in global screens as being sumoylated ...pombe translation initiation ...
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Regulation of the Translation Initiation Factor eIF4F by Multiple Mechanisms in Human Cytomegalovirus-Infected Cells
... As a viral opportunistic pathogen associated with serious disease among the immunocompromised and congenital defects in newborns, human cytomegalovirus (HCMV) must engage the translational machinery within its host cell ...
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Experimental Analysis of Mimivirus Translation Initiation Factor 4a Reveals Its Importance in Viral Protein Translation during Infection of Acanthamoeba polyphaga
... initiate translation, although its specific role remains ...eukaryotic initiation factor 4a (eIF4a), the R458 protein is the prototypical member of the ATP-dependent DEAD box RNA helicase ...mimivirus ...
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Efficient Translation of Rotavirus mRNA Requires Simultaneous Interaction of NSP3 with the Eukaryotic Translation Initiation Factor eIF4G and the mRNA 3′ End
... were counted at different times by trypan blue exclusion after trypsination. Mutagenesis and expression of recombinant NSP3. Expression of NSP3 fused to a track of 6 histidine residues in Escherichia coli using the T7 ...
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Specific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143
... (PKR) and the oligoadenylate synthetase (OAS)/RNase L system. As viral replication depends on protein synthesis, many viruses have evolved mechanisms for counteracting the PKR and OAS/RNase L pathways. The murine ...
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Helper Component Proteinase of the Genus Potyvirus Is an Interaction Partner of Translation Initiation Factors eIF(iso)4E and eIF4E and Contains a 4E Binding Motif
... eukaryotic translation initiation factor eIF4E and the isoform eIF(iso)4E, which interact with viral genome-linked protein ...with translation initiation factors and were detrimental to ...
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Herpes Simplex Virus 1 Infection Activates the Endoplasmic Reticulum Resident Kinase PERK and Mediates eIF-2α Dephosphorylation by the γ134.5 Protein
... of translation initiation factor eIF-2 (eIF-2 ␣ ...exchange factor eIF-2B, thus seques- tering eIF-2B in an inactive complex with phosphorylated eIF-2 and GDP (13, ...
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Vesicular Stomatitis Virus Oncolysis of T Lymphocytes Requires Cell Cycle Entry and Translation Initiation
... protein translation through two distinct mechanisms that in turn are crucial for cell cycle progression (28, ...mTOR: translation initiation, elongation, and/or ribosome biogenesis is stimulated by ...
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