Tyrosine residues
Conserved cytoplasmic tyrosine residues of the gamma subunit are required for a phagocytic signal mediated by Fc gamma RIIIA
... cytoplasmic tyrosine residues in the gamma chain resulted in markedly diminished phagocytosis and calcium ...of tyrosine kinases, reversibly inhibited ...cytoplasmic tyrosine residues ...
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Herpes Simplex Virus 1 UL37 Protein Tyrosine Residues Conserved among All Alphaherpesviruses Are Required for Interactions with Glycoprotein K, Cytoplasmic Virion Envelopment, and Infectious Virus Production
... conserved tyrosine residues to alanine revealed that they inhibited interactions of the UL37 protein with gK, suggesting that they are involved in these ...Y480 residues in a pocket-like ...
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NITRATION OF INDUCIBLE NITRIC OXIDE SYNTHASE TYROSINE RESIDUES IN RAW 264.7 MACROPHAGES
... compartments this could occur only if iso-superoxide-dismutase (SOD) activity were saturated or impaired [42]. In cultured ovine pulmonary arterial endothelial cells, the 4.5-fold increase in superoxide contributes to ...
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Transformation by avian sarcoma viruses leads to phosphorylation of multiple cellular proteins on tyrosine residues.
... This may be due either to experi- Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest transformed cells, ii the approximate size of the most abundant phosphotyrosine-contai[r] ...
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Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation
... 19 tyrosine residues in ELMO1, ten of them (Y60, 216, 352, 356, 395, 511, 646, 662, 720, and 724) satisfy criteria for potential Src-, but not SFKs-, dependent phosphorylation sites according to the ...
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Intracellular signaling pathways of ErbB2/HER 2 and family members
... Ligand binding to ErbB receptors results in dimerization and activation of their intrinsic kinase activity followed by phosphorylation of specific tyrosine residues in the recep- tor cytoplasmic tails. ...
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DEVELOPING SELECTIVE INHIBITORS OF PTP1B OVER TCPTP
... Insulin resistance is the primary cause for the type-2 diabetes, affected by more than 50million people in India. PTP1B is well characterized negative regulator of insulin receptor which suppress the insulin action by ...
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Identification and Characterization of Tyrosylprotein Sulfotransferase from Human Saliva
... tyrosyl residues are predominantly surrounded by acidic amino acids ...is tyrosine- rich and contains 7 tyrosine ...for tyrosine sulfation ...
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Studies on the electron acceptors of photosystem two
... The cofactors shown bound to the reaction centre are: P680, the special chlorophyll; two possible accessory chlorophylls; the tyrosine residues D and Z; two pheophy[r] ...
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Complex formation of EphB1/Nck/Caskin1 leads to tyrosine phosphorylation and structural changes of the Caskin1 SH3 domain
... of tyrosine residues 296 and 336 (Figure ...conserved tyrosine residues ...upon tyrosine phosphorylation of the SH3 ...these residues is clearly sensitive to phosphorylation, ...
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Nuclear Export of Simian Immunodeficiency Virus Vpx Protein
... phan residues at position 49, alone or in combination with those at positions 53 and 56, also abrogated Vpx packaging into virus-like particles ...106 residues with serine did not abrogate Vpx packaging ...
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Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University
... This results in the activation of the receptors kinase domain leading to cross-phosphorylation of tyrosine residues on the intracellular domain of the receptor providing a start for the [r] ...
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Sulfotyrosines of the Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Promote Tumorigenesis through Autocrine Activation
... containing residues 12 through 33 of vGPCR partially inhibited GRO- ␣ binding to vGPCR ...the tyrosine sulfate moieties as a molecular determinant for vGPCR association with GRO- ␣ , an impor- tant ...
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An Immunoreceptor Tyrosine Activation Motif in the Mouse Mammary Tumor Virus Envelope Protein Plays a Role in Virus-Induced Mammary Tumors
... immunoreceptor tyrosine activation motif (ITAM) in the SU ...The tyrosine residues found in the canonical motif D(xx)Yxx(L/ I)x 6-12 Yxx(L/I) are necessary and sufficient for signaling, and ...
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Abstract
... phospho− tyrosine residues of the number of the cytokine receptors (during signal transduction, phosphoryla− tion of amino−acid residues is the common ...
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CCR5 and CXCR4 Usage by Non-Clade B Human Immunodeficiency Virus Type 1 Primary Isolates
... of residues are important for CXCR4-mediated viral fusion and entry, but they are dispersed throughout the extracellular domains of CXCR4, and their usage is isolate ...and tyrosine residues. ...
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Adeno-Associated Virus Type 2-Mediated Gene Transfer: Role of Cellular FKBP52 Protein in Transgene Expression
... threonine residues, and this complex has been shown to mediate cyto- plasmic transport of a number of cellular and viral proteins to the nucleus ...rosine residues forms a complex with HSP90 remains un- ...
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Receptor tyrosine kinase signaling pathways: a review
... Fibroblast growth factors (FGFs) bind to the extracellular domain of the FGFRs inducing FGFR dimerization and transphosphorylation of intracellular tyrosine residues and activation of multiple downstream ...
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Site-directed mutagenesis of polyomavirus middle-T antigen sequences encoding tyrosine 315 and tyrosine 250.
... Interestingly, it has been demonstrated that tyrosine 250 becomes a prominent in vitro phosphate acceptor site in mutant middle-T antigens lacking other tyrosine residues and also when a[r] ...
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Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies
... exposed tyrosine resi- dues in binding of Etx to this cell line has not been ...of tyrosine mutants to ACHN cells we showed that surface exposed tyrosine residues in domain I of Etx do not ...
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