Ubiquitin activating enzyme E1
Mathematical model for the ubiquitin activating enzyme E1
... the ubiquitin activating enzyme, a system that seemed to be particularly appropriated for this mathe- matical ...the E1 system involving binding of substrates were considered in rapid ...
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Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination
... where ubiquitin (Ub) is transferred from a ubiquitin-activating enzyme (E1) to a catalytic cysteine on the ubiquitin-conjugating enzyme ...an ubiquitin ligase (E3) ...
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The KCTD family of proteins: structure, function, disease relevance
... successful ubiquitination of substrate proteins [26]. Cul3 is one of seven human cullin proteins (Cul1,Cul2,Cul3, Cul4A,Cul4B,Cul5, and Cul7). Most cullins form com- plexes with substrate proteins by interacting with the ...
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Ubiquitin conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection
... cells. Ubiquitin activating enzyme E1, several ubiquitin ligases E3s and proteins involved in protein translation (EIF4A2 and EIF4A2) or glycosylation ...
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Correcting temperature sensitive protein folding defects
... Recently, we found that different low molecular weight compounds, all known to stabilize proteins in their native conformation, are effective in correcting the temperature-sensitive protein folding defect associated with ...
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Analysis of binary interactions between OTUB1 and E2 ubiquitin-conjugating enzymes
... three enzyme families; E1 activating enzymes, E2 conjugating enzymes and E3 ligases, all of which work in a hierarchical manner to facilitate different forms of protein ubiquitin ranging from ...
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Replication of the Rotavirus Genome Requires an Active Ubiquitin-Proteasome System
... the ubiquitin-proteasome system is required for the efficient replication of rotavirus RRV in MA104 ...the E1 ubiquitin-activating enzyme was reduced at the restrictive ...of ...
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Ubiquitin conjugating enzyme involved in the immune response caused by pathogens invasion
... [1], ubiquitin-proteasome pathway (UPP) is responsible for the degradation of 80% - 90% bulk protein in eukaryotic cell ...of ubiquitin-activating en- zyme (E1), ubiquitin-conjugating ...
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Myositis-specific autoantibodies: detection and clinical associations
... to ubiquitin, and, like ubiquitin, can be post-translationally conjugated to other proteins by a similar ...SUMO-activating enzyme (E1) and involves the small ubiquitin-like ...
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Potential biomarkers for adult acute myeloid leukemia minimal residual disease assessment searched by serum peptidome profiling
... the E1 enzyme, while E1 enzyme is more actively used in malignant ...of E1 enzyme activity of the four leukemia cell lines by RNA interfer- ence and chemical inhibitors PYZD-4409 ...
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Molecular cloning and characterization of pigeon (Columba liva) ubiquitin and ubiquitin-conjugating enzyme genes from pituitary gland library
... post-translation. Ubiquitin-mediated proteolysis plays a universal role in the irreversible negative regulation of various signaling pathways [11], in- cluding those induced by pituitary hormones ...the ...
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A Cell Cycle-Regulated Toxoplasma Deubiquitinase, TgOTUD3A, Targets Polyubiquitins with Specific Lysine Linkages
... FIG 4 TgOTUD3A activity is directed specifically at polyubiquitin and is dependent on the catalytic cysteine (C229) in the active site. (A) Neither recombinant wild-type TgOTUD3A nor mutant TgOTUD3A (C229A) exhibited any ...
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Improved Chromatic and Sensory Characteristics of Plavac Mali Wines – Efficiency of Maceration Enzymes
... the enzyme use depends on the conditions of maceration, as well as on the characteristics of commercial preparations, their impurity, and potential contamination with other enzymes, beta-glucosidase or phenol ...
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A Kinetic Model for Amperometric Biosensor at Mixed Oxidase Enzyme
... total enzyme concentration in the film e e 1 e 2 , D S is the diffusion coefficient of substrate into polymer film, D B is the diffusion coefficient of hydrogen peroxide into polymer film, K M is the ...
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Characterization of a ubiquitinated protein which is externally located in African swine fever virions.
... a ubiquitin polypeptide covalently linked via its C terminus to an internal lysine of an unknown protein, then the N termini of both ubiquitin and the conjugated UB18 protein should be available for ...
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Prodrug activating systems in suicide gene therapy
... generally enzyme-mediated, extru- sion occurs spontaneously through the fragmenta- tion of the prodrug, often at a distinct ...the enzyme CPG2 (12, 13), followed by the spontaneous extrusion of the ...
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Chronic ingestion of alcohol modulates expression of ubiquitin editing enzyme A20 in lung macrophages
... of ubiquitin enzyme A20 in M ϕ was ...E3 ubiquitin ligases Itch and ring finger protein 11 (RNF11), A20 restricts NF κ B activation ...a ubiquitin-editing enzyme with both ...
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<p>Ubiquitin-specific protease 4 promotes glioblastoma multiforme via activating ERK pathway</p>
... We revealed that knockdown of USP4 could significantly inhibit cell proliferation and increase cell apoptosis via MAPK/ERK pathway both in vitro (Figures 2–4) and in vivo (Figure 5). T[r] ...
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A ubiquitin-conjugating enzyme, RAD6, affects the distribution of Ty1 retrotransposon integration positions.
... T h e sizes of the altered EcoRI bands defined the orientation of the Tyl ele- ments and indicated that four area IV insertions were probably Ty2 elements since they di[r] ...
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The reactions between active and inactive forms of wheat ribulosebisphosphate carboxylase and effectors
... In the presence of the effectors 6-phosphogluconate or NADPH, significantly lower concentrations of the activating co-factors can achieve full activation of both enzyme spe[r] ...
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