Ursolic Acid
EXTRACTION OF URSOLIC ACID FROM OCIMUM SANCTUM: MODULATORY EFFECT OF URSOLIC ACID ON HYDROGEN PEROXIDE INDUCED DNA DAMAGE IN HUMAN LYMPHOCYTES
... Extract ursolic acid , a pentacyclic triterpenoid from Ocimum sanctum; ii) develop a HPTLC based method for its quantification; and iii) investigate ursolic acid dependent adaptive response to ...
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Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells
... Background: Ursolic acid (UA), a natural pentacyclic triterpenoid, exerts anti-tumor effects in various cancer types including hepatocellular carcinoma ...
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Utilization of Dispersive Liquid Liquid Microextraction Coupled with HPLC UV as a Sensitive and Efficient Method for the Extraction and Determination of Oleanolic Acid and Ursolic Acid in Chinese Medicinal Herbs
... oleanolic acid (OA) and ursolic acid (UA) both have very low ultraviolet absorption and always exist in the same plant, so the separation and simultaneous determination of them have been a difficult ...
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Original Article Protective effect of ursolic acid on ischemic brain injury by regulating hypoxia-inducible factor 1-alpha
... oxygenase-2, inducible nitric oxide synthase (iNOS), vascular endothelial growth factor (VE- GF) and erythropoietin [21]. 2ME2 is a known to be an effective HIF-1α inhibitor evaluated by different clinical trials [22, ...
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EXTRACTION OF URSOLIC ACID FROM OCIMUM SANCTUM AND SYNTHESIS OF ITS DERIVATIVES: COMPARATIVE EVALUATION OF ANTI OXIDANT ACTIVITIES
... FIG. 3: INHIBITION OF LIPID PEROXIDATION INDUCED BY FE (II) OF (A) COMMERCIAL SYNTHETIC ANTIOXIDANTS TBHQ (40 G/ML); (B) URSOLIC ACID (UA) AND IT’S NOVEL DERIVATIVES UA-4 AND UA-7 AT CONCENTRATION OF 40 ...
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<p>Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway</p>
... Ursolic acid (UA) is a pentacyclic triterpenoid derived from the berries, fruits, leaves and fl owers of many med- icinal plants. It has been used for centuries in Asia as an antitumor, anti-in fl ammatory, ...
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THE EFFECTIVE ROLE OF URSOLIC ACID AND OCIMUM SANCTUM (LINN ) LEAF EXTRACT ON SOME MARKER CARBOHYDRATE METABOLITES IN MALE ALBINO RATS
... ABSTRACT: Ursolic acid is a pentacyclic triterpinoid compound, the major constituents of the Tulsi leaves, has been suggested to possess anti- fertility effect in rats of both ...and ursolic ...
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Comparison of anxiolytic activity of ondansetron and ursolic acid in chronic anxiety using elevated plus maze test
... and Ursolic Acid [TCI Chemicals (India) ...4,11 Ursolic Acid solution was freshly prepared in distilled water with 10% of Tween 80 and given in a dose of ...
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Estimation of Isolated Triterpenoid - Ursolic Acid in Verbena officinalis L. Aerial Parts Using TLC Densitometry
... The developed TLC densitometric method was validated for linearity, sensitivity, precision, accuracy and specificity for marker. The linearity, range, limit of detection, limit of quantification, inter day precision, ...
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Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats
... Ursolic acid (UA), a pentacyclic triterpenoid compound exits in many plants. It has anti-oxidant [40, 41], anti- inflammatory [42], anti-tumor [43], anti-apoptotic [44], and anti-fibrotic effects [45], all ...
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Original Article Ursolic acid derivative ameliorates streptozotocin- induced diabestic bone deleterious effects in mice
... The mice were randomly divided into three groups: (1) Vehicle group (n = 12); (2) Streptozotocin (STZ)-induced hyperglycemia mice (DM1, n = 12); (3) STZ with ursolic acid- treated group received ...
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A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis
... that ursolic acid (UA), a pentacyclic triterpene natural product, and its novel prodrug derivative US597 suppressed cancer cells adhesion, invasion and ...
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A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment
... Metastasis currently remains the predominant cause of breast carcinoma treatment failure. The effective targeting of metastasis-related-pathways in cancer holds promise for a new generation of therapeutics. In this ...
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A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver
... fibrosis. Ursolic acid (UA) is a pentacyclic triterpenoid with various pharmacological activities, but the molecular targets and underlying mechanisms for its antifibrotic effect in the liver remain ...
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Original Article Ursolic acid protects MC3T3-E1 cells against dexamethasone-mediated apoptosis, ROS generation and inflammation through activation of IGF-1
... Abstract: Ursolic acid (UA), a pentacyclic triterpenoid found in a variety of plants, has attracted considerable atten- tion because of its important biological and pharmacological ...
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“In-Vitro Analysis of Antibacterial Activity of Ocimum sanctum against Pathogenic Bacteria and Quantification of Ursolic Acid and Oleanolic Acid” by Ali R, Chauhan V, Farooq S, Khan A, Farooq U, India.
... India. Ursolic acid (UA), Oleanolic acid (OA) and Betulinic acid (BA), the derivatives of triterpenoid saponins, acts as a bioactive compounds and have been isolated from many medicinal plants ...
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<p>The Analysis of the Anti-Tumor Mechanism of Ursolic Acid Using Connectively Map Approach in Breast Cancer Cells Line MCF-7</p>
... A lot of natural products have been reported to have anti-cancer effects in various types of cancer. 5,6 Ursolic acid (UA) (Figure 1A) is a pentacyclic triterpe- noid compound extracted from naturally ...
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EVALUATION OF IN VIVO ANTIOXIDANT ACTIVITY OF URSOLIC ACID ACETATE ISOLATED FROM METHANOLIC EXTRACT OF COLEUS VETTIVEROIDES (JACOB) IN STREPTOZOTOCININDUCED OXIDATIVE STRESS IN RATS
... of Ursolic acid acetate isolated from methanolic extract of Coleus vettiveroides (jacob) in streptozotocin- induced oxidative stress in ...with Ursolic acid acetate isolated from methanolic ...
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Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo
... Abstract: Previous reports have shown that ursolic acid (UA), a pentacyclic triterpenoid derived from Catharanthus trichophyllus roots, could inhibit the growth of a series of cancer cells. However, the ...
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“Synthesis of Aniline Derivative of Ursolic Acid, its Metal Complexes, Characterization and Bioassay” by Azra Batool, Khadija Shahid*, Muhammad Muddasir, Pakistan.
... General Reaction for Synthesis of Metal Complexes Metal complexes (Sn, Sb, Cu, Fe, Zn) of aniline derivative of ursolic acid (Ligand) were synthesized with corresponding metal salts/halides i.e. tin halides ...
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