β-cell mass and function
PET/MRI enables simultaneous in vivo quantification of β-cell mass and function
... secretory function of pancreas, due to the high background signal from the exocrine pancreas observed during the early time ...reflecting β-cell mass, and the specific retention of Mn ...
13
Exercise preserves pancreatic β-cell mass and function in obese OLETF rats
... on β-cell function and mass remain ...the function and mass of β-cells in diabetic OLETF rats were ...islet β-cell mass and pancreatic insulin content ...
8
Impaired pancreatic growth, β cell mass, and β cell function in E2F1 –/– mice
... Type 2 diabetes mellitus (T2D) is a prevalent disorder of glucose homeostasis resulting from an imbalance between insulin secre- tion by pancreatic β cells and the sensitivity of peripheral tissues to insulin (1). ...
9
Growth hormone receptor regulates β cell hyperplasia and glucose stimulated insulin secretion in obese mice
... on β cell mass or function under normal conditions, but during obesity it may play a role in preserving β cell mass and ...in β cells. Furthermore, the effects of ...
6
GABAergic system in the endocrine pancreas: a new target for diabetes treatment
... pancreatic β-cell mass, mainly due to apoptosis, is a major factor in the development of hyperglycemia in both type 1 and type 2 diabetes (T1D and ...T1D, β-cells are destroyed by ...
9
Pdx1 restores β cell function in Irs2 knockout mice
... to β cells, the ability to com- pensate for peripheral insulin resistance by increasing β cell mass and insulin secretion might be impaired and lead to glucose intolerance and ...
10
MicroRNA 7a regulates pancreatic β cell function
... of β cells to secrete sufficient insulin to meet the increased metabolic demands asso- ciated with peripheral insulin resistance ...pancreatic β cell differentiation and function ...to ...
15
Chronic activation of a designer Gq coupled receptor improves β cell function
... STZ-treated β-Rq mice consuming regular water showed meta- bolic deficits that were similar in magnitude to those observed with STZ-treated WT mice (Figure 5, ...ed β-Rq mice maintained on CNO water showed ...
14
Advances in β cell replacement and regeneration strategies for treating diabetes
... progenitor cell stage (4, ...contain β and non-β islet cell types (4, ...mouse β cells are ablated after in vivo differentiation of the hPSC-derived progeni- tor cell grafts, the ...
11
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice
... the β cell, both via intracellular metabolic lipid signaling (19) and the free fatty acid receptor GPR40 ...in β cell function is PPARγ (NR1C3) ...response, cell differentiation, ...
14
Notch signaling dynamically regulates adult β cell proliferation and maturity
... “normal” β cell, but with 2 disparate outcomes: in young mice, Notch acti- vation represents an adaptive mechanism to increase β cell mass induced by insulin resistance by permissive ...
14
The role of insulin receptor substrate 2 in hypothalamic and β cell function
... of β cell function and peripheral glucose metabolism and the central regulation of energy homeostasis (10, 11, 19, ...both β cell growth and leptin and insulin action in the ...in ...
12
Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass
... of β cell mass in knockout ...proliferating β cells. Hence, disruption of the frataxin gene in pancreatic β cells causes dia- betes following cellular growth arrest and apoptosis, ...
9
The interplay between TGF-β and VEGF signalling in endothelial cell function
... a mass of proliferating cells, classically forming an inner core of hematopoietic precursor cells and an outer layer of ECs termed a blood island, followed by their subsequent migration, fusion and organization ...
177
Reversal of established autoimmune diabetes by restoration of endogenous β cell function
... pancreatic β cells is more than 90% complete by the time hyperglycemia becomes clinically evident in individuals with type 1 (insulin- dependent) diabetes ...islet cell replacement are necessary to restore ...
11
Identification of Potential Biomarkers in Acquired Cholesteatoma
... tissue function, make the characteristics of these proteins fully compatible with the theories already published about the pathophysiology of cholesteatoma (Table ...
11
Clinical characteristics and beta cell function in Chinese patients with newly diagnosed type 2 diabetes mellitus with different levels of serum triglyceride
... of β cell function in T2DM ...the β cell function through several ways, such as the increase of oxidative stress, activation of c-Jun N-terminal kinase pathway through activated ...
7
Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases
... negative isoforms (dn-TCF7) as transcription repressors. TCF7 interacts with multiple proteins and target genes (e.g. CD3E, β -catenin, TCF7L2, LEF-1, IL-17, IL-4, or Eomes) and is involved in several signal ...
13
Defining the effects of CD28 superagonist and TGF-β on T cell function and metabolism
... The binding of the peptide-‐MHC complex to the TCR initiates the formation of microclusters at distinct contact areas between the T cell and the APC. These microclusters represent essential membrane-‐associated ...
159
Gastric bypass and banding equally improve insulin sensitivity and β cell function
... b cell function in nondiabetic obese ...b cell function after weight loss were not different between surgical ...b cell function, and oral glucose tolerance in nondiabetic obese ...
9