V(D)J recombination
Evidence for failure of V(D)J recombination in bone marrow pre B cells from X linked agammaglobulinemia
... representative of XLA pre-B cells. I report that LS-C mu is the predominant Ig molecule produced by XLA pre-B cells, with limited production of the D mu product of DJH intermediate stage of ...
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Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N region insertions during V(D)J recombination
... of V(D)J ...human V(D)J recombination reaction, N regions were analyzed at both signal and coding ...pSJ-F1 V(D)J recombinants revealed insertions ...
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Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus
... the V(D)J recombination system and, as such, may inform strategies for increasing the accuracy of genome editing in clinical ...During V(D)J recombination, several ...
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Transcription-coupled eviction of histones H2A/H2B governs V(D)J recombination.
... of V(D)J recombination critically relies on the formation of an accessible chromatin structure at recombination signal sequences (RSSs) but how this accessibility is generated is poorly ...
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The E<lambda>3-1 Enhancer is Essential for V(D)J Recombination of the Murine Immunoglobulin Lambda Light Chain Locus
... V(D)J recombination generates a highly diverse antigen receptor repertoire but since the reaction involves the breakage and rejoining of DNA, it must be very tightly ...controlled. ...
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Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability
... The excision of intervening DNA from between the gene seg- ments to form an ESC by-product is an integral part of the V(D)J recombination reaction. Sealing the two signal ends was previously ...
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Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination.
... of V(D)J recombination ...of recombination, a plausible hypothesis is that the more accessible chromatin structure generated by histone acetylation facilitates the targeting of ...
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Biophysics of V(D)J Recombination and Genome Packaging: In Singulo Studies on RAG, HMGB1, and TFAM
... V(D)J recombination is one of the most intriguing examples of the striking dynam- ics of genomes. The specific mechanistic workings of such genome dynamics still entail many unanswered ...
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Adapting to a changing world: RAGgenomics and evolution
... In the past few decades, a lot of work has been carried out to elucidate the mechanisms coordinating the adaptive immune system; however, some questions remain unanswered, including the origin of RAG proteins, which ...
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Use of V(D)J recombination excision circles to identify T and B cell defects and to monitor the treatment in primary and acquired immunodeficiencies
... kappa-deleting recombination excision circles (KRECs) are circular DNA segments generated in T and B cells during their maturation in the thymus and bone ...
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Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination
... endogenous recombination of Ig gene segments in a Rag2- deficient pro-B cell line and that this correlated with decreased protein stability, impaired nuclear localization, and/or loss of the interaction between ...
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Immunoglobulin genes and diversity: what we have learned from domestic animals
... immunoglobulin V region diversity is generated. One is V(D)J recombination, a common mechanism that is utilized by most animals to generate V diversity through somatic DNA ...
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Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase
... lymphocytes. V(D)J recombination joins immunoglobulin and T-cell receptor (TCR) variable-region gene segments to generate the vast diversity of antigen specificities characteristic of ...
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Genetic Interaction Between the Non-homologous End Joining Factors during B and T Lymphocyte Development: In Vivo Mouse Models
... during V(D)J recombination to increase the repertoire of B and T cell ...switch recombination (CSR) process in mature B lymphocytes, providing distinct effector functions of antibody ...
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Dissecting the Epigenetic Regulation of V-beta Recombination
... process, V(D)J recombination (89). How V(D)J recombination is differentially used to assemble the various Ig and TCR genes during B and T cell development appears ...
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North south asymmetry of the substorm intensity depending on the IMF BY component
... and three events when the azimuthal IMF component is pos- itive. Longitudinal distributions of D (Fig. 1) have been constructed by magnetic data from world station network lo- cated on the North-American ...
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Die Mistiek 'n beskouing volgens die standpunt van N A Berdyaev (Berdjajew)
... veroorsaak. D ie moeilikheid van die geestelike iewe lê reeds opgesluit in die streng vereiste om versoening teweeg te bring tussen afskeiding van die vele en konsentrasie op die Eenheid met die bevryding en die ...
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Inference of the Properties of the Recombination Process from Whole Bacterial Genomes
... of recombination within than between the three major clades of ...ClonalFrame recombination seg- ments (Didelot et ...the recombination events and therefore is better able to detect ...
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Proefskrif en boekbesprekings
... lyn d e u r to t by die o p tr e d e s van G h a n d i (m e t sy Hindu- agtergrond, m aar ook bei'nvloed deur die bergrede) en Martin Luther King ( ’n C h r is te n w at d e u r G h a n ...
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Enkele Aantekeninge by die debat oor die uitleg van die Dordtse Leerreëls wat in 1871 deur Ds J J Kotze van Darling en Ds Andrew Murray Jnr gevoer is
... 22Die Dordtse Leerreëls, Hoofstuk 1:1: Aangesien alle mense in Adam gesondig en aan die vloek en die ewige dood skuldig geword het . . . Hoofstuk 1:7: . . . die hele menslike geslag wat deur hulle eie skuld van die ...
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