β-Elemene
Extraction and isolation of β elemene from Eupatorium adenophorum
... isolate β-elemene from worst weed Eupatorium adenophorum Spreng, identify its structure and determine its ...distillation, β-elemene was isolated by column chromatography with HP20 macroporous ...
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Novel hybrids of natural β elemene bearing isopropanolamine moieties: synthesis, enhanced anticancer profile, and improved aqueous solubility
... of β-elemene could favorably impact its water solubility and antitumor activity ...novel β-elemene isopropanolamine derivatives by introducing both amine and hydroxyl groups to increase the ...
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Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells
... Viability of HepG2 cells was assessed using MTT dye reduction assay (Sigma, USA), which was conducted as described previously [23]. Cells were seeded in a 96-well plate at a density of 1 ×10 4 cells/well, cultured for 12 ...
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Reversion of malignant phenotypes of human glioblastoma cells by β elemene through β catenin mediated regulation of stemness , differentiation and epithelial to mesenchymal transition related molecules
... of β-, γ- and δ-elemene [5]. β-Elemene (PubChem CID: 10583), the major active anticancer component in the elemene mixture, displays high anti-proliferative activity and induces ...
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Original Article Inhibitory effect of β-elemene on human breast cancer cells
... that β-elemene indeed induced the conversion of LC3-II from LC3-I (Figure ...with β-elemene, indicating that β-elemene indeed activates rather than inhib- its ...by ...
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The reversal of antineoplastic drug resistance in cancer cells by β-elemene
... that β -elemene affects the apoptotic process in cancer ...example, β -elemene significantly inhibits the growth and prolifera- tion of various types of T24 bladder cancer cell lines by ...
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The influence of astragalus polysaccharide and β-elemene on LX-2 cell growth, apoptosis and activation
... In summary, we used cultured human HSC cell line LX- 2 to study the growth inhibition effects of APS and ELE by morphology study, MTT assay and Annexin V/PI staining. We showed that both APS and ELE can inhibit LX-2 cell ...
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Discovery of novel antitumor nitric oxide donating b elemene hybrids through inhibiting the PI3K/Akt pathway
... that β-elemene exhibited its antineoplastic activity in vivo against various human tumors such as glioblastoma [6], liver [7] and breast [8] ...with β-elemene ...of β-elemene ...
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<p>β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway</p>
... in β -elemene combined radiation group was the slowest of the four groups, and it was slower than that of radiation ...rms β - elemene had a radiosensitive effect on lung cancer in ...and ...
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Preparation, characterization and relative bioavailability of oral elemene o/w microemulsion
... of β -elemene in elemene microemulsion, we compared the gel column chroma- tography and liquid surface ...free elemene as a volatile oil was insoluble in water and lighter in density than ...
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Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy
... (85% β -elemene), and it is also called “green therapy” for the treatment of ...clinic, elemene liposomes can be used as a single drug, be combined with chemoradiotherapy, or be used during the ...
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Chemical Constituents and Antimicrobial Activity of Essential Oil of Senna podocarpa (Guill et Perr ) Lock
... It could be seen that each oil sample has its own compositional pattern different from others. A noteworthy observation is the fact that mono (2-ethylhexyl) ester phthalate and β-elemene were not previously ...
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Formulation design, preparation, and in vitro and in vivo characterizations of β-Elemene- loaded nanostructured lipid carriers
... of β-Elemene ...the β-E-loaded NLCs were also less irritating and less toxic compared to Elemene ...addition, β-E-NLCs showed a significantly higher bioavailability and anti-tumor ...
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β-Elemene treatment of glioblastoma: a single-center retrospective study
... Abstract: Glioblastoma (GBM) is the most common primary malignancy in the central nervous system. In this study, we investigated the therapeutic effects of β-elemene (ELE) treatment in patients with newly ...
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TOTAL SYNTHESIS OF ANTICANCER NATURAL CYCLIC TETRAPEPTIDE AZUMAMIDE E, AMINOXY PEPTIDE OLIGOMERS AND PEG AS SOLVENT MEDIUM FOR HYDROGENATION
... The epoxy alcohol 11 was subjected to two step oxidation followed by esterfication to furnish the epoxy ester 12. In the epoxy ester 12 the epoxide functionality was regioselectively opened with lithium dimethyl cuprate ...
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TGF-β inhibits IL-1β-activated PAR-2 expression through multiple pathways in human primary synovial cells
... cartilage and inhibit synthesis of metalloproteinase inhib- itors such as TIMPs, tenascin and YKL-40. The anabolic mediators include TGF-β, IGF-1, FGFs and BMPs, which stimulate synthesis and repairing of ...
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Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent
... A β : amyloid-beta peptide; A β 40: 40 amino acid A β ; A β 42: 42 amino acid A β ; AD: Alzheimer ’ s disease; ANOVA: analysis of variance; BBB: blood-brain barrier; BCSFB: blood-CSF ...
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The search for the gene mutations underlying enterotoxigenic Escherichia coli F4ab/ac susceptibility in pigs: a review
... Together with the findings of Bijlsma et al., Billey et al. proposed three different types of F4 receptors [9,17]. The first kind of receptors “bcd” are receptors for all three F4 variants, F4ab, F4ac and F4ad. A second ...
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Impact of beta2-agonists, beta-blockers, and their combination on cardiac function in elderly male patients with chronic obstructive pulmonary disease
... of β 2 -agonists and β -blockers, yet most of them have been limited by the absence of detailed data on COPD status and high-risk patients, such as the ...prescribe β 2 -agonists for bronchospasm and ...
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Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation
... The authors are grateful for G. Thinakaran (The University of Chicago), T. Golde (University of Florida), B. De Strooper (VIB Leuven), Y. Li (Sloan- Kettering Cancer Center), and T. Kitamura (The University of Tokyo), S. ...
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